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Arrb2
Gene Detail
Symbol

Name
ID
Arrb2
arrestin, beta 2
MGI:99474
Synonyms
beta arr2, beta-arrestin2, beta-arrestin-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:70432635-70440828 bp, + strand
From VEGA annotation of GRCm38

  8194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ARRB2
Protein SuperFamily: arrestin
Gene Tree: Arrb2

Human
homologs
ARRB2, arrestin, beta 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 409
neXtProt AC: NX_P32121

Human Synonyms: ARB2, ARR2, BARR2

Human Chr (Location): 17p13; chr17:4710494-4721500 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Genomic Mutations involving Arrb2 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit enhanced morphine analgesia, an enhanced inflammatory response and reduced threshold to lethal endotoxin challenge, and impaired T and B lymphocyte chemotaxis.
 
Interactions
Arrb2 interacts with 164 markers (Mir17, Mir20b, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process adult walking behavior, cell chemotaxis, ...
Component basolateral plasma membrane, coated pit, ...
Function 14-3-3 protein binding, alpha-1A adrenergic receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (12)    Tissues (3)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
Western blot 6
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arrb2 ; ZFIN arrb2a, arrb2b    NEW 
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006049 (Evidence)
Ensembl Gene Model ENSMUSG00000060216 (Evidence)
Entrez Gene 216869 (Evidence)
UniGene 203747
DFCI TC1581135, TC1599054, TC1631013
DoTS DT.530327, DT.94333420, DT.97382835, DT.99858083
NIA Mouse Gene Index U012849
Consensus CDS Project CCDS24946.1, CCDS70226.1
International Mouse Phenotyping Consortium Status Arrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006049 VEGA Gene Model | MGI Sequence Detail 8194 C57BL/6J ±  kb
transcript OTTMUST00000040715 VEGA | MGI Sequence Detail 1777 Not Applicable 
polypeptide OTTMUSP00000018205 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(12) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000698 Arrestin
InterPro IPR017864 Arrestin, conserved site
InterPro IPR014752 Arrestin, C-terminal
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014753 Arrestin, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000004320 beta-arrestin-2
References
(Earliest) J:13280 Shinohara T, et al., A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila. Comp Biochem Physiol B Biochem Mol Biol. 1992 Nov;103(3):505-9
(Latest) J:220814 Liu X, et al., beta-Arrestin-biased signaling mediates memory reconsolidation. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4483-8
All references(131)
Other
accession IDs
MGD-MRK-16248, MGI:2144136, MGI:2144500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory