Arrb2
Gene Detail

Symbol Name ID

Arrb2 arrestin, beta 2 MGI:99474

Synonyms

beta arr2, beta-arrestin2, beta-arrestin-2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:70432635-70440828 bp, + strand From VEGA annotation of GRCm38   8194 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 zebrafish

Protein SuperFamily: arrestin
Gene Tree: Arrb2

Human homologs

Human Homolog		ARRB2, arrestin, beta 2
NCBI Gene ID		409
neXtProt AC		NX_P32121
Human Synonyms		ARB2, ARR2, BARR2
Human Chr (Location)		17p13; chr17:4613789-4624795 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Mice homozygous for a knock-out allele exhibit enhanced morphine analgesia, an enhanced inflammatory response and reduced threshold to lethal endotoxin challenge, and impaired T and B lymphocyte chemotaxis.

 

Gene Ontology (GO) classifications

All GO classifications: (76 annotations)

Process	adult walking behavior, apoptotic DNA fragmentation, ...
Component	basolateral plasma membrane, coated pit, ...
Function	14-3-3 protein binding, alpha-1A adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (2)    Images (6)
Theiler Stages: 23

Assay Type	Results
RNA in situ	6

cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(46)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006049 (Evidence)
Ensembl Gene Model	ENSMUSG00000060216 (Evidence)
Entrez Gene	216869 (Evidence)
UniGene	203747
DFCI	TC1581135, TC1599054, TC1631013
DoTS	DT.530327, DT.94333420, DT.97382835, DT.99858083
NIA Mouse Gene Index	U012849
Consensus CDS Project	CCDS24946.1
International Mouse Knockout Project Status	Arrb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006049	VEGA Gene Model | MGI Sequence Detail	8194	C57BL/6J
transcript	OTTMUST00000040715	VEGA | MGI Sequence Detail	1777	Not Applicable
polypeptide	OTTMUSP00000018205	VEGA | MGI Sequence Detail	421	Not Applicable

All sequences(79) RefSeq(8) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000698	Arrestin
InterPro	IPR017864	Arrestin, conserved site
InterPro	IPR014752	Arrestin, C-terminal
InterPro	IPR011022	Arrestin C-terminal-like domain
InterPro	IPR011021	Arrestin-like, N-terminal
InterPro	IPR014753	Arrestin, N-terminal
InterPro	IPR014756	Immunoglobulin E-set
Protein Ontology	PR:000004320	beta-arrestin-2

References

(Earliest) J:13280 Shinohara T, et al., A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila. Comp Biochem Physiol B Biochem Mol Biol. 1992 Nov;103(3):505-9
(Latest) J:192132 Por ED, et al., beta-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem. 2012 Oct 26;287(44):37552-63
All references(115)

Other accession IDs

MGD-MRK-16248, MGI:2144136, MGI:2144500