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Arrb2
Gene Detail
Symbol

Name
ID
Arrb2
arrestin, beta 2
MGI:99474
Synonyms
beta arr2, beta-arrestin2, beta-arrestin-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:70432635-70440828 bp, + strand
From VEGA annotation of GRCm38

  8194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: arrestin
Gene Tree: Arrb2

Human
homologs
Human Homolog ARRB2, arrestin, beta 2
NCBI Gene ID 409
neXtProt AC  NX_P32121
Human Synonyms  ARB2, ARR2, BARR2
Human Chr (Location)  17p13; chr17:4710494-4721500 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit enhanced morphine analgesia, an enhanced inflammatory response and reduced threshold to lethal endotoxin challenge, and impaired T and B lymphocyte chemotaxis.
 
Interactions
Arrb2 interacts with 164 markers (Mir17, Mir20b, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process adult walking behavior, cell chemotaxis, ...
Component basolateral plasma membrane, coated pit, ...
Function 14-3-3 protein binding, alpha-1A adrenergic receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (2)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006049 (Evidence)
Ensembl Gene ModelENSMUSG00000060216 (Evidence)
Entrez Gene216869 (Evidence)
UniGene203747
DFCITC1581135, TC1599054, TC1631013
DoTSDT.530327, DT.94333420, DT.97382835, DT.99858083
NIA Mouse Gene IndexU012849
Consensus CDS ProjectCCDS24946.1, CCDS70226.1
International Mouse Knockout Project StatusArrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006049 VEGA Gene Model | MGI Sequence Detail 8194 C57BL/6J ±  kb
transcript OTTMUST00000040715 VEGA | MGI Sequence Detail 1777 Not Applicable 
polypeptide OTTMUSP00000018205 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(12) UniProt(15)
Polymorphisms
RFLP(1) : SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000698 Arrestin
InterPro IPR017864 Arrestin, conserved site
InterPro IPR014752 Arrestin, C-terminal
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014753 Arrestin, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000004320 beta-arrestin-2
References
(Earliest) J:13280 Shinohara T, et al., A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila. Comp Biochem Physiol B Biochem Mol Biol. 1992 Nov;103(3):505-9
(Latest) J:212136 Gaffal E, et al., beta-Arrestin 2 Inhibits Proinflammatory Chemokine Production and Attenuates Contact Allergic Inflammation in the Skin. J Invest Dermatol. 2014 Aug;134(8):2131-7
All references(127)
Other
accession IDs
MGD-MRK-16248, MGI:2144136, MGI:2144500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory