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Arrb1 Gene Detail
Summary
  • Symbol
    Arrb1
  • Name
    arrestin, beta 1
  • Synonyms
    1200006I17Rik, beta-arrestin1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99473
    NCBI Gene: 109689
  • Gene Overview
    MyGene.info: ARRB1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99535486-99606772 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.09 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99473
protein coding gene Chr7:99535466-99606772 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032552
protein coding gene Chr7:102338634-102418246 (+)
A/J MGP_AJ_G0032526
protein coding gene Chr7:99792478-99864542 (+)
AKR/J MGP_AKRJ_G0032462
protein coding gene Chr7:102163825-102243104 (+)
BALB/cJ MGP_BALBcJ_G0032537
protein coding gene Chr7:99470933-99543015 (+)
C3H/HeJ MGP_C3HHeJ_G0032252
protein coding gene Chr7:102514741-102591854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033035
protein coding gene Chr7:106251865-106328006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030030
protein coding gene Chr7:102215458-102288936 (+)
CAST/EiJ MGP_CASTEiJ_G0031579
protein coding gene Chr7:94058741-94130536 (+)
CBA/J MGP_CBAJ_G0032219
protein coding gene Chr7:109899867-109979438 (+)
DBA/2J MGP_DBA2J_G0032371
protein coding gene Chr7:98124509-98197463 (+)
FVB/NJ MGP_FVBNJ_G0032328
protein coding gene Chr7:97917799-97990838 (+)
LP/J MGP_LPJ_G0032460
protein coding gene Chr7:103650901-103731285 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032360
protein coding gene Chr7:111349121-111426398 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033057
protein coding gene Chr7:101435865-101514098 (+)
PWK/PhJ MGP_PWKPhJ_G0031297
protein coding gene Chr7:91218648-91292373 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031140
protein coding gene Chr7:88735109-88811494 (+)
WSB/EiJ MGP_WSBEiJ_G0031696
protein coding gene Chr7:102110791-102187568 (+)



Homology
more
  • Human Ortholog
    ARRB1, arrestin beta 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARRB1, arrestin beta 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARB1, ARR1
  • Links
    NCBI Gene ID: 408
    neXtProt AC: NX_P49407
    UniProt: P49407

  • Chr Location
    11q13.4; chr11:75260122-75351831 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired quenching of rod photocurrent flash responses and greater sensitivity to beta-receptor agonist-stimulated ventricular ejection fraction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109689 NCBI Gene Model | MGI Sequence Detail 71287 C57BL/6J ±  kb
    transcript NM_177231 RefSeq | MGI Sequence Detail 7112 C57BL/6  
    polypeptide Q8BWG8 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 131

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16247, MGI:1921360, MGI:2142217, MGI:2444556
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 52
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:252027 Mittal N, et al., Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PLoS One. 2017;12(10):e0185796

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory