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Arrb1
Gene Detail
Symbol

Name
ID
Arrb1
arrestin, beta 1
MGI:99473
Synonyms
1200006I17Rik, beta-arrestin1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:99535466-99606771 bp, + strand
From VEGA annotation of GRCm38

  71306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: arrestin
Gene Tree: Arrb1

Human
homologs
Human Homolog ARRB1, arrestin, beta 1
NCBI Gene ID 408
neXtProt AC  NX_P49407
Human Synonyms  ARB1, ARR1
Human Chr (Location)  11q13; chr11:75260122-75351831 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired quenching of rod photocurrent flash responses and greater sensitivity to beta-receptor agonist-stimulated ventricular ejection fraction.
 
Interactions
Arrb1 interacts with 394 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process activation of MAPK activity, endocytosis, ...
Component basolateral plasma membrane, cell projection, ...
Function alpha-1A adrenergic receptor binding, alpha-1B adrenergic receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (211)    Tissues (35)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 211
cDNA source data(129)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(130) cDNA(130)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034019 (Evidence)
Ensembl Gene ModelENSMUSG00000018909 (Evidence)
Entrez Gene109689 (Evidence)
UniGene260193
DFCITC1576843, TC1594276, TC1600758
DoTSDT.94365337, DT.97407462
NIA Mouse Gene IndexU008440
Consensus CDS ProjectCCDS21484.1, CCDS40032.1
International Mouse Knockout Project StatusArrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034019 VEGA Gene Model | MGI Sequence Detail 71306 C57BL/6J ±  kb
transcript OTTMUST00000085875 VEGA | MGI Sequence Detail 7132 Not Applicable 
polypeptide OTTMUSP00000046443 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(12) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(656 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000698 Arrestin
InterPro IPR017864 Arrestin, conserved site
InterPro IPR014752 Arrestin, C-terminal
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014753 Arrestin, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000004319 beta-arrestin-1
References
(Earliest) J:13280 Shinohara T, et al., A family of retinal S-antigens (arrestins) and their genes: comparative analysis of human, mouse, rat, bovine and Drosophila. Comp Biochem Physiol B Biochem Mol Biol. 1992 Nov;103(3):505-9
(Latest) J:213559 Sharma D, et al., Nonhematopoietic beta-Arrestin-1 inhibits inflammation in a murine model of polymicrobial sepsis. Am J Pathol. 2014 Aug;184(8):2297-309
All references(81)
Other
accession IDs
MGD-MRK-16247, MGI:1921360, MGI:2142217, MGI:2444556

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory