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Sct
Gene Detail
 Symbol
Name
ID
Sct
secretin
MGI:99466
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.59 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:141278338-141279131 bp, - strand
From NCBI annotation of GRCm38

  794 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134323  Vertebrate Homology Class
1 mouse; 1 rat; 2 chicken

Protein SuperFamily: glucagon
Gene Tree: Sct

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
 
Mice homozygous for a null allele display impaired hippocampal synaptic function. Mice homozygous for a different knock-out allele fail exhibit increased water concsumption of vasopressin serum levels in response to ANGII treatment.
 
Interactions
Sct interacts with 11 markers (Mir10a, Mir137, Mir192, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process dentate gyrus development, negative regulation of neuron apoptotic process, ...
Component extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (64)    Tissues (33)    Images (75)
Theiler Stages: 17, 18, 20, 22, 23, 24
Assay TypeResults
Immunohistochemistry 29
RNA in situ 35
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(21)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000038580 (Evidence)
Entrez Gene20287 (Evidence)
UniGene4723
DFCITC1585611, TC1595535, TC1648628
DoTSDT.101355673, DT.487296
NIA Mouse Gene IndexU029453
Consensus CDS ProjectCCDS40184.1, CCDS72069.1
International Mouse Knockout Project StatusSct
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20287 NCBI Gene Model | MGI Sequence Detail 794 C57BL/6J ±  kb
transcript NM_001287171 RefSeq | MGI Sequence Detail 536 Not Specified 
polypeptide Q08535 UniProt | EBI | MGI Sequence Detail 133 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(5) UniProt(4)
Polymorphisms SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
InterPro IPR015675 Secretin
Protein Ontology PR:000014543 secretin
Graphical View of Protein Domain Structure
References (Earliest) J:17989 Lan MS, et al., cDNA sequence and genomic organization of mouse secretin. Biochem Biophys Res Commun. 1994 Apr 29;200(2):1066-71
(Latest) J:208291 Sekar R, et al., Lipolytic actions of secretin in mouse adipocytes. J Lipid Res. 2014 Feb;55(2):190-200
All references(56)
Other
accession IDs
MGD-MRK-16237

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory