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Sct
Gene Detail
Symbol

Name
ID
Sct
secretin
MGI:99466
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.59 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:141278331-141279133 bp, - strand
From Ensembl annotation of GRCm38

  803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134323  Vertebrate Homology Class
1 mouse; 1 rat; 2 chicken

HCOP human homology predictions: SCT
Protein SuperFamily: glucagon
Gene Tree: Sct

Human
homologs
SCT, secretin
Orthology source: HGNC

IDs:
NCBI Gene ID: 6343
neXtProt AC: NX_P09683

Human Chr (Location): 11p15.5; chr11:624989-627240 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
 
Mice homozygous for a null allele display impaired hippocampal synaptic function. Mice homozygous for a different knock-out allele fail exhibit increased water concsumption of vasopressin serum levels in response to ANGII treatment.
 
Interactions
Sct interacts with 11 markers (Mir10a, Mir137, Mir192, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (22 records)
Data Summary: Results (64)    Tissues (33)    Images (75)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 35
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(21)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000038580 (Evidence)
Entrez Gene 20287 (Evidence)
UniGene 4723
DFCI TC1585611, TC1595535, TC1648628
DoTS DT.101355673, DT.487296
NIA Mouse Gene Index U029453
Consensus CDS Project CCDS40184.1, CCDS72069.1
International Mouse Phenotyping Consortium Status Sct
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038580 Ensembl Gene Model | MGI Sequence Detail 803 C57BL/6J ±  kb
transcript ENSMUST00000046156 Ensembl | MGI Sequence Detail 534 Not Applicable 
polypeptide ENSMUSP00000041519 Ensembl | MGI Sequence Detail 139 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
InterPro IPR015675 Secretin
Protein Ontology PR:000014543 secretin
References
(Earliest) J:17989 Lan MS, et al., cDNA sequence and genomic organization of mouse secretin. Biochem Biophys Res Commun. 1994 Apr 29;200(2):1066-71
(Latest) J:218169 Donnison M, et al., Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015 Jan 1;397(1):77-88
All references(59)
Other
accession IDs
MGD-MRK-16237

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory