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Mef2c
Gene Detail
 Symbol
Name
ID
Mef2c
myocyte enhancer factor 2C
MGI:99458
Synonyms 5430401D19Rik, 9930028G15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
43.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:83573607-83664472 bp, + strand
From VEGA annotation of GRCm38

  90866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mef2c

Human
homologs
Human Homolog MEF2C, myocyte enhancer factor 2C
NCBI Gene ID 4208
neXtProt AC  NX_Q06413
Human Synonyms  C5DELq14.3, DEL5q14.3
Human Chr (Location)  5q14.3; chr5:88718241-88904105 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MEF2C
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have cardiovascular abnormalities and die as embryos.
 
Interactions
Mef2c interacts with 491 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (160 annotations)
Process apoptotic process, B cell homeostasis, ...
Component cytoplasm, cytosol, ...
Function activating transcription factor binding, AT DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (120 records)
Data Summary: Results (643)    Tissues (293)    Images (114)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 580
RT-PCR 52
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(25) Primer pair(15) Other(6)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000044481 (Evidence)
Ensembl Gene ModelENSMUSG00000005583 (Evidence)
Entrez Gene17260 (Evidence)
DFCITC1578068, TC1581529, TC1585786, TC1587474, TC1602563, TC1632215, TC1642111, TC1642955, TC1663206, TC1741388
DoTSDT.101134290, DT.101384071, DT.101384072, DT.101737823, DT.110973492, DT.529653, DT.530574, DT.91300777, DT.97397130
NIA Mouse Gene IndexU015066
Consensus CDS ProjectCCDS26664.1, CCDS49320.1
International Mouse Knockout Project StatusMef2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044481 VEGA Gene Model | MGI Sequence Detail 90866 C57BL/6J ±  kb
transcript OTTMUST00000117106 VEGA | MGI Sequence Detail 3480 Not Applicable 
polypeptide OTTMUSP00000065499 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(32) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1099 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022102 Holliday junction regulator protein family C-terminal
InterPro IPR002100 Transcription factor, MADS-box
Protein Ontology PR:000010311 myocyte-specific enhancer factor 2C
References (Earliest) J:17643 Martin JF, et al., Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5282-6
(Latest) J:207388 Liu N, et al., Requirement of MEF2A, C, and D for skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4109-14
All references(223)
Other
accession IDs
MGD-MRK-16227, MGI:1918600, MGI:2145387, MGI:2443757

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory