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Mef2c
Gene Detail
Symbol

Name
ID
Mef2c
myocyte enhancer factor 2C
MGI:99458
Synonyms
5430401D19Rik, 9930028G15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
43.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:83573607-83664472 bp, + strand
From VEGA annotation of GRCm38

  90866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mef2c

Human
homologs
Human Homolog MEF2C, myocyte enhancer factor 2C
NCBI Gene ID 4208
neXtProt AC  NX_Q06413
Human Synonyms  C5DELq14.3, DEL5q14.3
Human Chr (Location)  5q14.3; chr5:88718241-88904105 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MEF2C
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have cardiovascular abnormalities and die as embryos.
 
Interactions
Mef2c interacts with 491 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (164 annotations)
Process apoptotic process, B cell homeostasis, ...
Component cytoplasm, cytosol, ...
Function activating transcription factor binding, AT DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (125 records)
Data Summary: Results (643)    Tissues (293)    Images (114)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 580
RT-PCR 52
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(25) Primer pair(15) Other(6)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044481 VEGA Gene Model | MGI Sequence Detail 90866 C57BL/6J ±  kb
transcript OTTMUST00000117106 VEGA | MGI Sequence Detail 3480 Not Applicable 
polypeptide OTTMUSP00000065499 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(32) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(1099 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022102 Holliday junction regulator protein family C-terminal
InterPro IPR002100 Transcription factor, MADS-box
Protein Ontology PR:000010311 myocyte-specific enhancer factor 2C
References
(Earliest) J:17643 Martin JF, et al., Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5282-6
(Latest) J:213214 Shenje LT, et al., Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors. Elife. 2014;3:e02164
All references(231)
Other
accession IDs
MGD-MRK-16227, MGI:1918600, MGI:2145387, MGI:2443757

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory