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Ckmt1
Gene Detail
Symbol

Name
ID
Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
MGI:99441
STS
Synonyms
mi-CK, Mt-CK, UbCKmit
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.37 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:121357714-121363737 bp, + strand
From VEGA annotation of GRCm38

  6024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69058  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: creatine kinase
Gene Tree: Ckmt1

Human
homologs
Human Homolog CKMT1A, creatine kinase, mitochondrial 1A
NCBI Gene ID 548596
neXtProt AC  NX_P12532
Human Synonyms  CKMT1
Human Chr (Location)  15q15; chr15:43692886-43699222 (+)  GRCh38
Human Homolog CKMT1B, creatine kinase, mitochondrial 1B
NCBI Gene ID 1159
neXtProt AC  NX_P12532
Human Synonyms  CKMT, CKMT1, UMTCK
Human Chr (Location)  15q15; chr15:43593054-43599406 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele have no visual or motor impairments but display diminished open field habituation and slower spatial learning acquisition in the Morris water maze task as well as a reduced acoustic startle response, higher threshold, and lack of prepulse inhibition.
 
Interactions
Ckmt1 interacts with 150 markers (Mir1b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphorylation
Component extracellular vesicular exosome, membrane, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (267)    Tissues (127)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 267
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(3) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015261 (Evidence)
Ensembl Gene ModelENSMUSG00000000308 (Evidence)
Entrez Gene12716 (Evidence)
DFCITC1575314, TC1590889, TC1726319
DoTSDT.534734, DT.94168654, DT.94168699
NIA Mouse Gene IndexU002349
EC2.7.3.2
Consensus CDS ProjectCCDS16640.1
International Mouse Knockout Project StatusCkmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015261 VEGA Gene Model | MGI Sequence Detail 6024 C57BL/6J ±  kb
transcript OTTMUST00000036155 VEGA | MGI Sequence Detail 1518 Not Applicable 
polypeptide OTTMUSP00000016245 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(6) UniProt(15)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022415 ATP:guanido phosphotransferase active site
InterPro IPR022414 ATP:guanido phosphotransferase, catalytic domain
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Protein Ontology PR:000006183 creatine kinase U-type, mitochondrial
References
(Earliest) J:21973 Steeghs K, et al., The ubiquitous mitochondrial creatine kinase gene maps to a conserved region on human chromosome 15q15 and mouse chromosome 2 bands F1-F3. Genomics. 1994 Nov 1;24(1):193-5
(Latest) J:190279 Cui J, et al., Expression of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibits the Processing of uMtCK to Induce Cell Death in cell culture model system. Biosci Rep. 2011 Mar 4;
All references(53)
Other
accession IDs
MGD-MRK-16205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory