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Cd33 Gene Detail
Summary
  • Symbol
    Cd33
  • Name
    CD33 antigen
  • Synonyms
    gp67, Siglec-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99440
    NCBI Gene: 12489
Location & Maps
more
  • Sequence Map
    Chr7:43524216-43544428 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20213 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CD33, CD33 molecule
  • Human Ortholog
    CD33, CD33 molecule
    Orthology source: HGNC
  • Synonyms
    p67, SIGLEC3, SIGLEC-3
  • Links
    NCBI Gene ID: 945
    neXtProt AC: NX_P20138

  • Chr Location
    19q13.3; chr19:51215537-51240019 (+)  GRCh38.p2
  • HCOP
    human homology predictions: CD33
  • Gene Tree
    Cd33
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show slight reductions in mean erythrocyte count and hematocrit and increased concentration of blood aspartate aminotransaminase. There is also a hyporesponsiveness to induced peritonitis and a weaker IL-6 response to LPS-induced systemic inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    8
  • Tissues
    8
  • cDNA Data
    10
  • Literature Summary
    1
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058533 VEGA Gene Model | MGI Sequence Detail 20213 C57BL/6J ±  kb
transcript OTTMUST00000143722 VEGA | MGI Sequence Detail 1962 Not Applicable  
polypeptide OTTMUSP00000074921 VEGA | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    257 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-16204
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:18452 Tchilian EZ, et al., Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen. Blood. 1994 Jun 1;83(11):3188-98
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory