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Cd33 Gene Detail
Summary
  • Symbol
    Cd33
  • Name
    CD33 antigen
  • Synonyms
    gp67, Siglec-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99440
    NCBI Gene: 12489
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43176823-43186679 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99440
 protein coding gene Chr7:43173640-43193852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032130
 protein coding gene Chr7:43543144-43552343 (-)
A/J MGP_AJ_G0032115
 protein coding gene Chr7:42651676-42660869 (-)
AKR/J MGP_AKRJ_G0032045
 protein coding gene Chr7:44031565-44036981 (-)
BALB/cJ MGP_BALBcJ_G0032120
 protein coding gene Chr7:42770921-42776337 (-)
C3H/HeJ MGP_C3HHeJ_G0031836
 protein coding gene Chr7:44527002-44532418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032604
 protein coding gene Chr7:45743463-45748879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029627
 protein coding gene Chr7:44770815-44793828 (-)
CAST/EiJ MGP_CASTEiJ_G0031166
 protein coding gene Chr7:35700936-35720252 (-)
CBA/J MGP_CBAJ_G0031805
 protein coding gene Chr7:47193151-47198567 (-)
DBA/2J MGP_DBA2J_G0031954
 protein coding gene Chr7:42459779-42465177 (-)
FVB/NJ MGP_FVBNJ_G0031915
 protein coding gene Chr7:42174072-42179488 (-)
LP/J MGP_LPJ_G0032033
 protein coding gene Chr7:44282082-44302232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031951
 protein coding gene Chr7:46139476-46144892 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032624
 protein coding gene Chr7:43155810-43164989 (-)
PWK/PhJ MGP_PWKPhJ_G0030887
 protein coding gene Chr7:35901831-35918297 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030726
 protein coding gene Chr7:31202703-31208104 (-)
WSB/EiJ MGP_WSBEiJ_G0031280
 protein coding gene Chr7:43699554-43719690 (-)



Homology
more
  • Human Ortholog
    CD33, CD33 molecule
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD33, CD33 molecule
  • Synonyms
    p67, SIGLEC3, SIGLEC-3
  • Links
    NCBI Gene ID: 945
    neXtProt AC: NX_P20138
    UniProt: P20138

  • Chr Location
    19q13.41; chr19:51211054-51240019 (+)  GRCh38.p7
  • Human Ortholog
    SIGLEC6, sialic acid binding Ig like lectin 6
  • Synonyms
    CD327, CD33L, CD33L1, CD33L2, CDW327, OBBP1
  • Links
    NCBI Gene ID: 946
    neXtProt AC: NX_O43699
    UniProt: O43699

  • Chr Location
    19q13.41; chr19:51517725-51531859 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show slight reductions in mean erythrocyte count and hematocrit and increased concentration of blood aspartate aminotransaminase. There is also a hyporesponsiveness to induced peritonitis and a weaker IL-6 response to LPS-induced systemic inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    680
  • Tissues
    8
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12489 NCBI Gene Model | MGI Sequence Detail 9857 C57BL/6J ±  kb
    transcript NM_001111058 RefSeq | MGI Sequence Detail 2571 Not Specified  
    polypeptide Q63994 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 11

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-16204
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:18452 Tchilian EZ, et al., Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen. Blood. 1994 Jun 1;83(11):3188-98
    • Latest
      J:289756 Duan S, et al., CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen. J Clin Invest. 2019 Mar 1;129(3):1387-1401
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/28/2022
    MGI 6.20     		The Jackson Laboratory