Arl4a MGI Mouse Gene Detail - MGI:99437 - ADP-ribosylation factor-like 4A

Symbol

Arl4a
Name

ADP-ribosylation factor-like 4A
Synonyms

Arl4

Feature Type

protein coding gene
IDs

MGI:99437
NCBI Gene: 11861
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:40083290-40087986 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 18.06 cM
Mapping Data

3 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99437	protein coding gene	Chr12:40055446-40088024 (-)
129S1/SvImJ	ENSMUSG00200011503	protein coding gene	Chr12:31958140-31962874 (-)
A/J	ENSMUSG00195016517	protein coding gene	Chr12:34638097-34642831 (-)
AKR/J	ENSMUSG00220005097	protein coding gene	Chr12:32628148-32632882 (-)
BALB/cJ	ENSMUSG00180003583	protein coding gene	Chr12:33625252-33629986 (-)
C3H/HeJ	ENSMUSG00175016285	protein coding gene	Chr12:36678535-36683269 (-)
C57BL/6NJ	ENSMUSG00215011050	protein coding gene	Chr12:33021946-33026680 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017715	protein coding gene	Chr12:36287280-36320314 (-)
CAST/EiJ	ENSTCUG00005003575	protein coding gene	Chr12:33392097-33396820 (-)
CBA/J	ENSMUSG00210015982	protein coding gene	Chr12:33157611-33162345 (-)
DBA/2J	ENSMUSG00185019951	protein coding gene	Chr12:35190797-35195490 (-)
FVB/NJ	ENSMUSG00205001332	protein coding gene	Chr12:33041302-33046034 (-)
JF1/MsJ	ENSUMUG00000008900	protein coding gene	Chr12:39376412-39381131 (-)
LP/J	ENSMUSG00230010009	protein coding gene	Chr12:42123269-42128003 (-)
NOD/ShiLtJ	ENSMUSG00190003558	protein coding gene	Chr12:32187097-32191829 (-)
NZO/HlLtJ	ENSMUSG00225030693	protein coding gene	Chr12:44342154-44346888 (-)
PWK/PhJ	ENSLUMG00010012372	protein coding gene	Chr12:33531700-33536421 (-)
SPRET/EiJ	ENSMSPG00010001868	protein coding gene	Chr12:34372661-34377395 (-)
WSB/EiJ	ENSIUOG00005001268	protein coding gene	Chr12:32914734-32919466 (-)

Human Ortholog

ARL4A, ARF like GTPase 4A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARL4A, ARF like GTPase 4A
Synonyms

ARL4
Links

HGNC:695

NCBI Gene ID: 10124

UniProt: P40617
Chr Location

7p21.3; chr7:12686602-12690958 (+) GRCh38

MGI Vertebrate Homology

Arl4a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARL4A
Gene Tree

Arl4a

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

5
Targeted

2
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in small testes, reduced sperm count, and abnormal spermiogenesis. Both male and female homozygotes are fertile.

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All GO Annotations

28
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

63
cDNA Data

82
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arl4a

ZFIN arl4aa, arl4ab

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All Sequences

55
RefSeq

4
UniProt

3
CCDS

CCDS25890.1

Ensembl

ENSMUSG00000047446 (Evidence)
NCBI Gene

11861

			Length	Strain/Species	Flank
genomic	11861	NCBI Gene Model \| MGI Sequence Detail	4697	C57BL/6J	± kb
transcript	NM_001039515	RefSeq \| MGI Sequence Detail	3693	ZRU/MplStud
polypeptide	P61213	UniProt \| EBI \| MGI Sequence Detail	200	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004285 ADP-ribosylation factor-like protein 4A

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding domain

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All nucleic 86

Genomic 1

cDNA 83

Primer pair 1

Other 1

Antibodies 1

Microarray probesets 8

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MGD-MRK-16201, MGI:2144843

Summaries

All 42

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 6
Earliest

J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arl4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116156	Chr12:40088209-40088221 (-)	-229 bp
Tssr116155	Chr12:40088029-40088040 (-)	-49 bp
Tssr116154	Chr12:40087918-40088012 (-)	21 bp
Tssr116153	Chr12:40087654-40087666 (-)	326 bp
Tssr116152	Chr12:40087623-40087629 (-)	360 bp
Tssr116151	Chr12:40087386-40087410 (-)	588 bp
Tssr116150	Chr12:40087367-40087381 (-)	612 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24