About   Help   FAQ
Arf6
Gene Detail
Symbol

Name
ID
Arf6
ADP-ribosylation factor 6
MGI:99435
Feature Type
protein coding gene
Genetic Map
Chromosome 12
28.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:69372150-69375979 bp, + strand
From Ensembl annotation of GRCm38

  3830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ARF6
Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arf6

Human
homologs
ARF6, ADP-ribosylation factor 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 382
neXtProt AC: NX_P62330

Human Chr (Location): 14q21.3; chr14:49893018-49897054 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Mice homozygous for a null allele display embryonic and perinatal lethality beginning around mid-gestation, impaired liver development, and edema.
 
Interactions
Arf6 interacts with 347 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cell cycle, cell differentiation, ...
Component cell cortex, cell projection, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (306)    Tissues (212)    Images (124)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 226
Western blot 80
cDNA source data(104)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase arf6, arf6.2 ; ZFIN arf6a    NEW 
Molecular
reagents
All nucleic(111) cDNA(109) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000044147 (Evidence)
Entrez Gene 11845 (Evidence)
UniGene 27308
DFCI TC1578752, TC1704671
DoTS DT.101739372, DT.489245, DT.493210, DT.91336168, DT.94395111
NIA Mouse Gene Index U014025
PDB 3VHX
Consensus CDS Project CCDS25952.1
International Mouse Phenotyping Consortium Status Arf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044147 Ensembl Gene Model | MGI Sequence Detail 3830 C57BL/6J ±  kb
transcript ENSMUST00000050063 Ensembl | MGI Sequence Detail 3730 Not Applicable 
polypeptide ENSMUSP00000055862 Ensembl | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006689 Small GTPase superfamily, ARF/SAR type
InterPro IPR024156 Small GTPase superfamily, ARF type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000004205 ADP-ribosylation factor 6
References
(Earliest) J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
(Latest) J:207374 Mitrea DM, et al., Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4466-71
All references(56)
Other
accession IDs
MGD-MRK-16199, MGI:2144883, MGI:2145032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory