About   Help   FAQ
Arf6
Gene Detail
 Symbol
Name
ID
Arf6
ADP-ribosylation factor 6
MGI:99435
Feature Type protein coding gene
Genetic Map
Chromosome 12
28.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:69372150-69375979 bp, + strand
From Ensembl annotation of GRCm38

  3830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arf6

Human
homologs
Human Homolog ARF6, ADP-ribosylation factor 6
NCBI Gene ID 382
neXtProt AC  NX_P62330
Human Chr (Location)  14q21.3; chr14:49893018-49897054 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Gene trapped(2) Targeted(2)
 
Mice homozygous for a null allele display embryonic and perinatal lethality beginning around mid-gestation, impaired liver development, and edema.
 
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process cell cycle, cell differentiation, ...
Component cell cortex, cell projection, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (306)    Tissues (179)    Images (124)
Theiler Stages: 19, 20, 21, 23, 26, 28
Assay TypeResults
RNA in situ 226
Western blot 80
cDNA source data(104)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(111) cDNA(109) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000044147 (Evidence)
Entrez Gene11845 (Evidence)
UniGene27308
DFCITC1578752, TC1704671
DoTSDT.101739372, DT.489245, DT.493210, DT.91336168, DT.94395111
NIA Mouse Gene IndexU014025
PDB3VHX
Consensus CDS ProjectCCDS25952.1
International Mouse Knockout Project StatusArf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044147 Ensembl Gene Model | MGI Sequence Detail 3830 C57BL/6J ±  kb
transcript ENSMUST00000050063 Ensembl | MGI Sequence Detail 3730 Not Applicable 
polypeptide ENSMUSP00000055862 Ensembl | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006689 Small GTPase superfamily, ARF/SAR type
InterPro IPR024156 Small GTPase superfamily, ARF type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000004205 ADP-ribosylation factor 6
References (Earliest) J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
(Latest) J:201931 Kobayashi H, et al., Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. J Cell Sci. 2013 Jun 1;126(Pt 11):2424-35
All references(55)
Other
accession IDs
MGD-MRK-16199, MGI:2144883, MGI:2145032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory