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Arf4
Gene Detail
Symbol

Name
ID
Arf4
ADP-ribosylation factor 4
MGI:99433
Feature Type
protein coding gene
Genetic Map
Chromosome 14
16.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:26638074-26665084 bp, + strand
From VEGA annotation of GRCm38

  27011 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55593  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ADP-ribosylation factor
Gene Tree: Arf4

Human
homologs
Human Homolog ARF4, ADP-ribosylation factor 4
NCBI Gene ID 378
neXtProt AC  NX_P18085
Human Synonyms  ARF2
Human Chr (Location)  3p21.2-p21.1; chr3:57571363-57597488 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele exhibit embryonic lethality. Mice hoeterozygous for the gene trap allele exhibit failure to increase exploration of an object in a novel context, reduced spine density and reduced mESPC amplitudes.
 
Phenotype Images(1)
Interactions
Arf4 interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process activation of phospholipase D activity, cell migration, ...
Component cytoplasm, cytosol, ...
Function epidermal growth factor receptor binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (227)    Tissues (78)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 227
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035433 (Evidence)
Ensembl Gene ModelENSMUSG00000021877 (Evidence)
Entrez Gene11843 (Evidence)
DFCITC1573278, TC1734229
DoTSDT.101390297, DT.537033, DT.94390513
Consensus CDS ProjectCCDS26881.1
International Mouse Knockout Project StatusArf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035433 VEGA Gene Model | MGI Sequence Detail 27011 C57BL/6J ±  kb
transcript OTTMUST00000090601 VEGA | MGI Sequence Detail 2165 Not Applicable 
polypeptide OTTMUSP00000049738 VEGA | MGI Sequence Detail 180 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006689 Small GTPase superfamily, ARF/SAR type
InterPro IPR024156 Small GTPase superfamily, ARF type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000004203 ADP-ribosylation factor 4
References
(Earliest) J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
(Latest) J:194029 Sadakata T, et al., Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 2012 Feb;279(3):384-94
All references(41)
Other
accession IDs
MGD-MRK-16197, MGI:1353617

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory