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Arf1 Gene Detail
Summary
  • Symbol
    Arf1
  • Name
    ADP-ribosylation factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99431
    NCBI Gene: 11840
  • Gene Overview
    MyGene.info: ARF1
Location & Maps
more
  • Sequence Map
    Chr11:59211414-59228270 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16857 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.05 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARF1, ADP ribosylation factor 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ARF1, ADP ribosylation factor 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 375
    neXtProt AC: NX_P84077

  • Chr Location
    1q42; chr1:228082660-228099212 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Targeted
    4
  • Genomic Mutations
    1 involving Arf1
  • Incidental Mutations
Homozygous embryos die in utero shortly after implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006340 VEGA Gene Model | MGI Sequence Detail 16857 C57BL/6J ±  kb
transcript OTTMUST00000014412 VEGA | MGI Sequence Detail 1800 Not Applicable  
polypeptide OTTMUSP00000006686 VEGA | MGI Sequence Detail 181 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004201 ADP-ribosylation factor 1
  • PDB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR006689 Small GTPase superfamily, ARF/SAR type
    IPR024156 Small GTPase superfamily, ARF type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 34
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-16195
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
  • Latest
    J:220201 Hayakawa N, et al., The ADP-ribosylation factor 1 gene is indispensable for mouse embryonic development after implantation. Biochem Biophys Res Commun. 2014 Oct 31;453(4):748-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory