Arf1 MGI Mouse Gene Detail - MGI:99431 - ADP-ribosylation factor 1

Arf1 Gene Detail

Symbol

Arf1
Name

ADP-ribosylation factor 1

Feature Type

protein coding gene
IDs

MGI:99431
NCBI Gene: 11840
Gene Overview

MyGene.info: ARF1

Sequence Map

Chr11:59211414-59228270 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

16857 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.05 cM, cytoband B2
Mapping Data

2 experiments

Human Ortholog

ARF1, ADP ribosylation factor 1

Vertebrate Orthologs

11

Human Ortholog

ARF1, ADP ribosylation factor 1
Orthology source: HomoloGene, HGNC
Links

HGNC:652

NCBI Gene ID: 375

neXtProt AC: NX_P84077

UniProt: P84077
Chr Location

1q42.13; chr1:228082660-228099212 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 133930
1 human;1 mouse;1 rat;2 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ARF1
Protein SuperFamily

ADP-ribosylation factor
Gene Tree

Arf1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Gene trapped

22
Targeted

4
Genomic Mutations

1 involving Arf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Homozygous embryos die in utero shortly after implantation.

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All GO Annotations

62
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

26
Tissues

17
cDNA Data

33
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARF1

ZFIN arf1

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Arf1 interacts with 224 markers (Mir1a-1, Mir1a-2, Mir7-2, ...) View All

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All Sequences

58
RefSeq

4
UniProt

1
CCDS

CCDS24765.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000006340	VEGA Gene Model \| MGI Sequence Detail	16857	C57BL/6J	± kb
transcript	OTTMUST00000014412	VEGA \| MGI Sequence Detail	1800	Not Applicable
polypeptide	OTTMUSP00000006686	VEGA \| MGI Sequence Detail	181	Not Applicable

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SNPs within 2kb

78 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000004201 ADP-ribosylation factor 1

(term hierarchy)
PDB

1O3Y, 2J59
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain

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All nucleic 35

cDNA 34

Primer pair 1

Microarray probesets 6

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MGD-MRK-16195

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:240324 Rodrigues FF, et al., The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. Mol Biol Cell. 2016 Oct 15;27(20):3143-3155

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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