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Hira
Gene Detail
 Symbol
Name
ID
Hira
histone cell cycle regulation defective homolog A (S. cerevisiae)
MGI:99430
Synonyms D16Ertd95e, Tuple1
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.69 cM, cytoband A-B1
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr16:18877037-18970309 bp, + strand
From VEGA annotation of GRCm38

  93273 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48172  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hira

Human
homologs
Human Homolog HIRA, histone cell cycle regulator
NCBI Gene ID 7290
neXtProt AC  NX_P54198
Human Synonyms  DGCR1, TUP1, TUPLE1
Human Chr (Location)  22q11.21; chr22:19330701-19431696 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(35) Targeted(8) Transposon induced(1)
Genomic Mutations involving Hira (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit disrupted gastrulation, malformations of axial and paraxial mesoendoderm, abnormal placentas, failure of cardiac development, and lethality by embryonic day 11.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Hira interacts with 301 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chromatin modification, DNA replication-independent nucleosome assembly, ...
Component nuclear chromatin, nucleus, ...
Function chromatin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (122)    Tissues (59)    Images (25)
Theiler Stages: 16, 17, 19, 20, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 43
Northern blot 1
RT-PCR 62
cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) Genomic(34) cDNA(32) Primer pair(4) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026265 (Evidence)
Ensembl Gene ModelENSMUSG00000022702 (Evidence)
Entrez Gene15260 (Evidence)
DFCITC1578857, TC1585766, TC1603118, TC1610178, TC1723326
DoTSDT.110727115, DT.110727144, DT.110727186, DT.483384, DT.484501, DT.484628, DT.91447040
NIA Mouse Gene IndexU016902, U056472
Consensus CDS ProjectCCDS28031.1
International Mouse Knockout Project StatusHira
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026265 VEGA Gene Model | MGI Sequence Detail 93273 C57BL/6J ±  kb
transcript OTTMUST00000064953 VEGA | MGI Sequence Detail 4218 Not Applicable 
polypeptide OTTMUSP00000032308 VEGA | MGI Sequence Detail 1015 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019015 HIRA B motif
InterPro IPR011494 TUP1-like enhancer of split
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008570 protein HIRA
References (Earliest) J:32846 Halford S, et al., Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. Hum Mol Genet. 1993 Dec;2(12):2099-107
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(68)
Other
accession IDs
MGD-MRK-16194, MGI:1098613, MGI:1858444, MGI:2146730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory