St3gal2 MGI Mouse Gene Detail - MGI:99427 - ST3 beta-galactoside alpha-2,3-sialyltransferase 2

Symbol

St3gal2
Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 2
Synonyms

Siat5, ST3GalII

Feature Type

protein coding gene
IDs

MGI:99427
NCBI Gene: 20444
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr8:111646554-111699112 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 57.81 cM
Mapping Data

3 experiments

SNPs within 2kb

1496 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99427	protein coding gene	Chr8:111646520-111699132 (+)
129S1/SvImJ	ENSMUSG00200013537	protein coding gene	Chr8:105950749-106003320 (+)
A/J	ENSMUSG00195018032	protein coding gene	Chr8:106263351-106315929 (+)
AKR/J	ENSMUSG00220015160	protein coding gene	Chr8:106405773-106458350 (+)
BALB/cJ	ENSMUSG00180018653	protein coding gene	Chr8:106268769-106321221 (+)
C3H/HeJ	ENSMUSG00175023793	protein coding gene	Chr8:106325673-106378246 (+)
C57BL/6NJ	ENSMUSG00215034930	protein coding gene	Chr8:105928713-105981266 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031566	protein coding gene	Chr8:102010158-102066105 (+)
CAST/EiJ	ENSTCUG00005033573	protein coding gene	Chr8:105680182-105732655 (+)
CBA/J	ENSMUSG00210029883	protein coding gene	Chr8:106252822-106305396 (+)
DBA/2J	ENSMUSG00185017178	protein coding gene	Chr8:112361941-112414506 (+)
FVB/NJ	ENSMUSG00205021196	protein coding gene	Chr8:105265285-105317864 (+)
JF1/MsJ	ENSUMUG00000015228	protein coding gene	Chr8:114695218-114747789 (+)
LP/J	ENSMUSG00230033290	protein coding gene	Chr8:116041745-116094295 (+)
NOD/ShiLtJ	ENSMUSG00190023973	protein coding gene	Chr8:106403822-106456387 (+)
NZO/HlLtJ	ENSMUSG00225021611	protein coding gene	Chr8:119392407-119444982 (+)
PWK/PhJ	ENSLUMG00010027139	protein coding gene	Chr8:106138352-106190707 (+)
SPRET/EiJ	ENSMSPG00010039121	protein coding gene	Chr8:108286475-108301101 (+)
WSB/EiJ	ENSIUOG00005027935	protein coding gene	Chr8:107057001-107109531 (+)

Human Ortholog

ST3GAL2, ST3 beta-galactoside alpha-2,3-sialyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ST3GAL2, ST3 beta-galactoside alpha-2,3-sialyltransferase 2
Synonyms

Gal-NAc6S, SIAT4B, ST3GalA.2, ST3GALII
Links

HGNC:10863

NCBI Gene ID: 6483

UniProt: Q16842
Chr Location

16q22.1; chr16:70375977-70439263 (-) GRCh38

MGI Vertebrate Homology

St3gal2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ST3GAL2
Protein SuperFamily

Sialyl_trans
Gene Tree

St3gal2

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

3
Gene trapped

19
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene apparently display a normal phenotype.

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All GO Annotations

43
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

118
cDNA Data

68
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase st3gal2, st3gal8

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All Sequences

64
RefSeq

12
UniProt

6
CCDS

CCDS22667.1

Ensembl

ENSMUSG00000031749 (Evidence)
NCBI Gene

20444

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031749	Ensembl Gene Model \| MGI Sequence Detail	52559	C57BL/6J	± kb
transcript	ENSMUST00000034197	Ensembl \| MGI Sequence Detail	4396	Not Applicable
polypeptide	ENSMUSP00000034197	Ensembl \| MGI Sequence Detail	350	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000030354 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

(term hierarchy)
EC

2.4.3.2, 2.4.3.4
InterPro Domains

IPR051757 Beta-galactoside alpha2-3 sialyltransferases

IPR001675 Glycosyl transferase family 29

IPR038578 GT29-like superfamiliy

IPR012163 Sialyltransferase
GlyGen

Q11204 1 site, 1 N-linked glycan (1 site)

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All nucleic 71

cDNA 68

Primer pair 3

Microarray probesets 6

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MGD-MRK-16190, MGI:2142539, MGI:2142821

Summaries

All 56

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 16
Earliest

J:17521 Lee YC, et al., Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase. J Biol Chem. 1994 Apr 1;269(13):10028-33
Latest

J:334166 Gonzalez-Gil A, et al., Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. J Biol Chem. 2022 Apr 20;298(6):101960

TSS for St3gal2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79440	Chr8:111646458-111646488 (+)	-81 bp
Tssr79441	Chr8:111646506-111646534 (+)	-34 bp
Tssr79442	Chr8:111646548-111646626 (+)	33 bp
Tssr79444	Chr8:111667541-111667558 (+)	20,996 bp
Tssr79445	Chr8:111667563-111667580 (+)	21,018 bp
Tssr79446	Chr8:111667583-111667607 (+)	21,041 bp
Tssr79447	Chr8:111667612-111667613 (+)	21,059 bp
Tssr79448	Chr8:111682967-111682992 (+)	36,426 bp
Tssr79449	Chr8:111684359-111684385 (+)	37,818 bp
Tssr79450	Chr8:111684393-111684406 (+)	37,846 bp
Tssr79451	Chr8:111687800-111687803 (+)	41,248 bp
Tssr2687	Chr8:111689480-111689483 (+)	42,928 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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