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Mc5r Gene Detail
Summary
  • Symbol
    Mc5r
  • Name
    melanocortin 5 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:99420
    NCBI Gene: 17203
  • Gene Overview
    MyGene.info: MC5R
Location & Maps
more
  • Sequence Map
    Chr18:68337603-68339711 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2109 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 41.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MC5R, melanocortin 5 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MC5R, melanocortin 5 receptor
    Orthology source: HomoloGene
  • Synonyms
    MC2
  • Links
    NCBI Gene ID: 4161
    neXtProt AC: NX_P33032

  • Chr Location
    18p11.2; chr18:13825544-13826862 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids. Males exhibit less aggressive and more defensive behavior when placed with wildtype males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007480 Ensembl Gene Model | MGI Sequence Detail 2109 C57BL/6J ±  kb
transcript ENSMUST00000172148 Ensembl | MGI Sequence Detail 1162 Not Applicable  
polypeptide ENSMUSP00000130497 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 4
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16182
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:17828 Labbe O, et al., Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry. 1994 Apr 19;33(15):4543-9
  • Latest
    J:215467 Lute B, et al., Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5;20(2):333-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory