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Mc5r Gene Detail
Summary
  • Symbol
    Mc5r
  • Name
    melanocortin 5 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:99420
    NCBI Gene: 17203
  • Gene Overview
    MyGene.info: MC5R
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:68337596-68342446 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 41.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99420
protein coding gene Chr18:68337258-68342446 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024535
protein coding gene Chr18:68686352-68688460 (+)
A/J MGP_AJ_G0024502
protein coding gene Chr18:65709187-65711295 (+)
AKR/J MGP_AKRJ_G0024473
protein coding gene Chr18:67620678-67622786 (+)
BALB/cJ MGP_BALBcJ_G0024502
protein coding gene Chr18:65869102-65871210 (+)
C3H/HeJ MGP_C3HHeJ_G0024270
protein coding gene Chr18:67762884-67764992 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024948
protein coding gene Chr18:70493916-70496024 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022379
protein coding gene Chr18:65057370-65059486 (+)
CAST/EiJ MGP_CASTEiJ_G0023743
protein coding gene Chr18:67798922-67801031 (+)
CBA/J MGP_CBAJ_G0024239
protein coding gene Chr18:72905171-72907279 (+)
DBA/2J MGP_DBA2J_G0024369
protein coding gene Chr18:65323640-65325748 (+)
FVB/NJ MGP_FVBNJ_G0024335
protein coding gene Chr18:64701129-64703237 (+)
LP/J MGP_LPJ_G0024453
protein coding gene Chr18:68542369-68544477 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024365
protein coding gene Chr18:74172907-74175015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024996
protein coding gene Chr18:67793600-67795708 (+)
PWK/PhJ MGP_PWKPhJ_G0023487
protein coding gene Chr18:65647508-65649616 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023291
protein coding gene Chr18:67943591-67945693 (+)
WSB/EiJ MGP_WSBEiJ_G0023806
protein coding gene Chr18:67699399-67701507 (+)



Homology
more
  • Human Ortholog
    MC5R, melanocortin 5 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MC5R, melanocortin 5 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MC2
  • Links
    NCBI Gene ID: 4161
    neXtProt AC: NX_P33032
    UniProt: P33032

  • Chr Location
    18p11.21; chr18:13825544-13826862 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids. Males exhibit less aggressive and more defensive behavior when placed with wildtype males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007480 Ensembl Gene Model | MGI Sequence Detail 4851 C57BL/6J ±  kb
transcript ENSMUST00000172148 Ensembl | MGI Sequence Detail 3904 Not Applicable  
polypeptide ENSMUSP00000130497 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 13
    Genomic 4
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16182
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:17828 Labbe O, et al., Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry. 1994 Apr 19;33(15):4543-9
  • Latest
    J:215467 Lute B, et al., Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5;20(2):333-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory