Id4
Gene Detail

Symbol Name ID

Id4 inhibitor of DNA binding 4 MGI:99414

Synonyms

bHLHb27, Id4, Idb4

Feature Type

protein coding gene

Genetic Map

Chromosome 13

24.71 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:48261427-48264036 bp, + strand From NCBI annotation of GRCm38   2610 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1186  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 zebrafish

Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id4

Human homologs

Human Homolog		ID4, inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
NCBI Gene ID		3400
neXtProt AC		NX_P47928
Human Synonyms		bHLHb27, IDB4
Human Chr (Location)		6p22.3; chr6:19837601-19842431 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene have reduced brains and abnormal telencephalon structures.

 
Human Diseases Modeled Using Mouse Id4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	brain development, cell proliferation, ...
Component	cytoplasm, nucleus
Function	protein binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (40 records)
Data Summary: Results (221)    Tissues (134)    Images (20)
Theiler Stages: 2, 3, 10, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	104
In situ reporter (knock in)	1
Northern blot	42
Western blot	3
RT-PCR	68
RNase protection	3

cDNA source data(58)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(75) Genomic(10) cDNA(58) Primer pair(6) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000021379 (Evidence)
Entrez Gene	15904 (Evidence)
UniGene	458006
DFCI	TC1582936, TC1721224
DoTS	DT.94184764, DT.97409099
NIA Mouse Gene Index	U014805
Consensus CDS Project	CCDS26492.1
International Mouse Knockout Project Status	Id4

Sequences

Length	Strain/Species
genomic	15904	NCBI Gene Model | MGI Sequence Detail	2610	C57BL/6J
transcript	NM_031166	RefSeq | MGI Sequence Detail	1660	C57BL/6
polypeptide	P41139	UniProt | EBI | MGI Sequence Detail	161	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026052	DNA-binding protein inhibitor
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000000042	DNA-binding protein inhibitor ID-4

Graphical View of Protein Domain Structure

References

(Earliest) J:17442 Riechmann V, et al., The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res. 1994 Mar 11;22(5):749-55
(Latest) J:181942 Hirai S, et al., RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex. EMBO J. 2012 Mar 7;31(5):1190-202
All references(76)

Other accession IDs

MGD-MRK-16175