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Id4 Gene Detail
Summary
  • Symbol
    Id4
  • Name
    inhibitor of DNA binding 4
  • Synonyms
    bHLHb27, Id4, Idb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99414
    NCBI Gene: 15904
  • Gene Overview
    MyGene.info: ID4
Location & Maps
more
  • Sequence Map
    Chr13:48261427-48264036 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2610 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 24.71 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ID4, inhibitor of DNA binding 4, HLH protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ID4, inhibitor of DNA binding 4, HLH protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHb27, IDB4
  • Links
    NCBI Gene ID: 3400
    neXtProt AC: NX_P47928

  • Chr Location
    6p22.3; chr6:19837370-19842200 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Id4 mouse models

Human Disease Mouse Models
       Osteoporosis   OMIM: 166710 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Id4
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene have reduced brains and abnormal telencephalon structures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15904 NCBI Gene Model | MGI Sequence Detail 2610 C57BL/6J ±  kb
transcript NM_031166 RefSeq | MGI Sequence Detail 1660 C57BL/6  
polypeptide P41139 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    7 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000042 DNA-binding protein inhibitor ID-4
  • InterPro Domains
    IPR026052 DNA-binding protein inhibitor
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 74
    Genomic 10
    cDNA 56
    Primer pair 6
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-16175
References
more
  • Summaries
    All 90
    Developmental Gene Expression 54
    Diseases 1
    Gene Ontology 12
    Phenotypes 15
  • Earliest
    J:17442 Riechmann V, et al., The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res. 1994 Mar 11;22(5):749-55
  • Latest
    J:231817 Matsumoto S, et al., Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development. J Neurosci. 2016 Apr 27;36(17):4744-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory