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Id4
Gene Detail
Symbol

Name
ID
Id4
inhibitor of DNA binding 4
MGI:99414
Synonyms
bHLHb27, Id4, Idb4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
24.71 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:48261427-48264036 bp, + strand
From NCBI annotation of GRCm38

  2610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1186  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id4

Human
homologs
Human Homolog ID4, inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
NCBI Gene ID 3400
neXtProt AC  NX_P47928
Human Synonyms  bHLHb27, IDB4
Human Chr (Location)  6p22.3; chr6:19837348-19842200 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene have reduced brains and abnormal telencephalon structures.
 
Human Diseases Modeled Using Mouse Id4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Id4 interacts with 198 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, cell proliferation, ...
Component cytoplasm, nucleus
Function protein binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (225)    Tissues (136)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
In situ reporter (knock in) 1
Northern blot 42
Western blot 3
RT-PCR 68
RNase protection 3
cDNA source data(56)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) Genomic(10) cDNA(56) Primer pair(6) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021379 (Evidence)
Entrez Gene15904 (Evidence)
UniGene458006
DFCITC1582936, TC1721224
DoTSDT.94184764, DT.97409099
NIA Mouse Gene IndexU014805
Consensus CDS ProjectCCDS26492.1
International Mouse Knockout Project StatusId4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15904 NCBI Gene Model | MGI Sequence Detail 2610 C57BL/6J ±  kb
transcript NM_031166 RefSeq | MGI Sequence Detail 1660 C57BL/6 
polypeptide P41139 UniProt | EBI | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026052 DNA-binding protein inhibitor
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000000042 DNA-binding protein inhibitor ID-4
Graphical View of Protein Domain Structure
References
(Earliest) J:17442 Riechmann V, et al., The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res. 1994 Mar 11;22(5):749-55
(Latest) J:207823 Sharma P, et al., Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer. 2013 Jun 21;12(1):67
All references(86)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16175

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory