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Adora2b Gene Detail
Summary
  • Symbol
    Adora2b
  • Name
    adenosine A2b receptor
  • Synonyms
    A2b, A2BAR, A2BR, A2b, Rs, AA2BR
  • Feature Type
    protein coding gene
  • IDs
    MGI:99403
    NCBI Gene: 11541
  • Gene Overview
    MyGene.info: ADORA2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:62248984-62266453 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17470 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADORA2B, adenosine A2b receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADORA2B, adenosine A2b receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADORA2
  • Links
    NCBI Gene ID: 136
    neXtProt AC: NX_P29275
    UniProt: P29275

  • Chr Location
    17p12; chr17:15927781-15975896 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 6 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in low-grade inflammation, augmentation of proinflammatory cytokines and increased leukocyte adhesion to the vasculature.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005854 VEGA Gene Model | MGI Sequence Detail 17470 C57BL/6J ±  kb
    transcript OTTMUST00000013020 VEGA | MGI Sequence Detail 1845 Not Applicable  
    polypeptide OTTMUSP00000006053 VEGA | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      128 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16164, MGI:2144194, MGI:2144239
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 78
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256095 Huang WC, et al., Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain. Neuron. 2017 Mar 8;93(5):1094-1109.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory