About   Help   FAQ
Adora2b
Gene Detail
 Symbol
Name
ID
Adora2b
adenosine A2b receptor
MGI:99403
Synonyms A2b, A2BAR, A2BR, A2b, Rs, AA2BR
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:62248984-62266453 bp, + strand
From VEGA annotation of GRCm38

  17470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenosine receptor
Gene Tree: Adora2b

Human
homologs
Human Homolog ADORA2B, adenosine A2b receptor
NCBI Gene ID 136
neXtProt AC  NX_P29275
Human Synonyms  ADORA2
Human Chr (Location)  17p12; chr17:15944917-15975896 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in low-grade inflammation, augmentation of proinflammatory cytokines and increased leukocyte adhesion to the vasculature.
 
Interactions
Adora2b interacts with 129 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process adenosine receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component cell surface, integral component of membrane, ...
Function G-protein coupled adenosine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (206)    Tissues (85)    Images (20)
Theiler Stages: 19, 21, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 66
RT-PCR 138
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005854 (Evidence)
Ensembl Gene ModelENSMUSG00000018500 (Evidence)
Entrez Gene11541 (Evidence)
UniGene40740
DFCITC1581007
DoTSDT.110540620, DT.97387597
NIA Mouse Gene IndexU012730
Consensus CDS ProjectCCDS24822.1
International Mouse Knockout Project StatusAdora2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005854 VEGA Gene Model | MGI Sequence Detail 17470 C57BL/6J ±  kb
transcript OTTMUST00000013020 VEGA | MGI Sequence Detail 1845 Not Applicable 
polypeptide OTTMUSP00000006053 VEGA | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001435 Adenosine A2B receptor
InterPro IPR001634 Adenosine receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001577 adenosine receptor A2b
References (Earliest) J:24044 Stehle JH, et al., Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol. 1992 Mar;6(3):384-93
(Latest) J:209549 Koscso B, et al., Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 2013 Dec;94(6):1309-15
All references(110)
Other
accession IDs
MGD-MRK-16164, MGI:2144194, MGI:2144239

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory