Adora2b MGI Mouse Gene Detail - MGI:99403

Symbol

Adora2b
Name

adenosine A2b receptor
Synonyms

A2b, A2BAR, A2BR, A2b, Rs, AA2BR, ARA2B

Feature Type

protein coding gene
IDs

MGI:99403
NCBI Gene: 11541
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:62139810-62157278 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

584 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99403	protein coding gene	Chr11:62139810-62157279 (+)
129S1/SvImJ	ENSMUSG00200035286	protein coding gene	Chr11:59061914-59079407 (+)
A/J	ENSMUSG00195031509	protein coding gene	Chr11:59099502-59116971 (+)
AKR/J	ENSMUSG00220048211	protein coding gene	Chr11:59204249-59221731 (+)
BALB/cJ	ENSMUSG00180045057	protein coding gene	Chr11:59152584-59170054 (+)
C3H/HeJ	ENSMUSG00175039307	protein coding gene	Chr11:59116628-59134098 (+)
C57BL/6NJ	ENSMUSG00215031593	protein coding gene	Chr11:58859597-58877068 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016488	protein coding gene	Chr11:57073380-57091417 (+)
CAST/EiJ	ENSTCUG00005038669	protein coding gene	Chr11:58673946-58691642 (+)
CBA/J	ENSMUSG00210035528	protein coding gene	Chr11:58949688-58967160 (+)
DBA/2J	ENSMUSG00185041448	protein coding gene	Chr11:59131239-59148735 (+)
FVB/NJ	ENSMUSG00205036461	protein coding gene	Chr11:59020579-59038067 (+)
JF1/MsJ	ENSUMUG00000043992	protein coding gene	Chr11:59572142-59589848 (+)
LP/J	ENSMUSG00230047517	protein coding gene	Chr11:60283143-60300633 (+)
NOD/ShiLtJ	ENSMUSG00190027991	protein coding gene	Chr11:59130538-59148025 (+)
NZO/HlLtJ	ENSMUSG00225044530	protein coding gene	Chr11:62426509-62444002 (+)
PWK/PhJ	ENSLUMG00010026948	protein coding gene	Chr11:59087892-59105456 (+)
SPRET/EiJ	ENSMSPG00010039863	protein coding gene	Chr11:59751367-59768961 (+)
WSB/EiJ	ENSIUOG00005036181	protein coding gene	Chr11:59054126-59071599 (+)

Human Ortholog

ADORA2B, adenosine A2b receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADORA2B, adenosine A2b receptor
Synonyms

ADORA2
Links

HGNC:264

NCBI Gene ID: 136

UniProt: P29275
Chr Location

17p12; chr17:15850362-15975746 (+) GRCh38

MGI Vertebrate Homology

Adora2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADORA2B
Gene Tree

Adora2b

less

Phenotype Summary

37 phenotypes from 6 alleles in 10 genetic backgrounds
3 phenotypes from multigenic genotypes
114 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

9
Targeted

11
Genomic Mutations

1 involving Adora2b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in low-grade inflammation, augmentation of proinflammatory cytokines and increased leukocyte adhesion to the vasculature.

less

All GO Annotations

52
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

853
Tissues

100
cDNA Data

18
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adora2b

ZFIN adora2b

less

All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS24822.1

Ensembl

ENSMUSG00000018500 (Evidence)
NCBI Gene

11541

			Length	Strain/Species	Flank
genomic	11541	NCBI Gene Model \| MGI Sequence Detail	17469	C57BL/6J	± kb
transcript	NM_007413	RefSeq \| MGI Sequence Detail	1844	C57BL/6
polypeptide	Q60614	UniProt \| EBI \| MGI Sequence Detail	332	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000001577 adenosine receptor A2b

(term hierarchy)
InterPro Domains

IPR001435 Adenosine A2B receptor

IPR001634 Adenosine receptor

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q60614 2 sites

less

All nucleic 21

cDNA 18

Primer pair 3

Antibodies 1

Microarray probesets 7

less

MGD-MRK-16164, MGI:2144194, MGI:2144239

Summaries

All 192

Developmental Gene Expression 12

Gene Ontology 15

Phenotypes 114
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:375518 Crockett SL, et al., Caffeine-associated reduction in patent ductus arteriosus is mediated in part by adenosine receptor antagonism. Am J Physiol Heart Circ Physiol. 2025 Dec 1;329(6):H1548-H1559

TSS for Adora2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101999	Chr11:62139803-62139837 (+)	10 bp
Tssr102000	Chr11:62139838-62139853 (+)	36 bp
Tssr102001	Chr11:62139888-62139899 (+)	84 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24