Adora1
Gene Detail

Symbol Name ID

Adora1 adenosine A1 receptor MGI:99401

Synonyms

A1AR, A1-AR, A1R, AA1R, Ri

Feature Type

protein coding gene

Genetic Map

Chromosome 1

58.15 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:134199223-134235431 bp, - strand From Ensembl annotation of GRCm38   36209 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: adenosine receptor
Gene Tree: Adora1

Human homologs

Human Homolog		ADORA1, adenosine A1 receptor
NCBI Gene ID		134
neXtProt AC		NX_P30542
Human Synonyms		RDC7
Human Chr (Location)		1q32.1; chr1:203096836-203136533 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygotes for a null allele show anxiety, hyperalgesia, allodynia and altered neuronal and brainstem respiratory activity upon hypoxia. Homozygotes for another null allele are susceptible to renal reperfusion injury, and lack tubuloglomerular feedback responses and 5'-AMP-induced bradycardia.

 

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	activation of MAPKK activity, adenosine receptor signaling pathway, ...
Component	asymmetric synapse, axolemma, ...
Function	G-protein beta/gamma-subunit complex binding, G-protein coupled adenosine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (99)    Tissues (50)    Images (2)
Theiler Stages: 12, 14, 18, 21, 23, 25, 28

Assay Type	Results
RT-PCR	99

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000042429 (Evidence)
Entrez Gene	11539 (Evidence)
NIA Mouse Gene Index	U021783
Consensus CDS Project	CCDS15305.1
International Mouse Knockout Project Status	Adora1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000042429	Ensembl Gene Model | MGI Sequence Detail	36209	C57BL/6J
transcript	ENSMUST00000169927	Ensembl | MGI Sequence Detail	4581	Not Applicable
polypeptide	ENSMUSP00000132105	Ensembl | MGI Sequence Detail	326	Not Applicable

All sequences(42) RefSeq(5) UniProt(7)

Polymorphisms

SNPs(272 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001068	Adenosine A1 receptor
InterPro	IPR001634	Adenosine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001575	adenosine receptor A1

References

(Earliest) J:17705 Marquardt DL, et al., Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J Immunol. 1994 May 1;152(9):4508-15
(Latest) J:192653 Yang P, et al., Loss of A(1) adenosine receptor attenuates alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Toxicol Sci. 2013 Jan;131(1):128-38
All references(146)

Other accession IDs

MGD-MRK-16162, MGI:2138349, MGI:2138644