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Adora1
Gene Detail
 Symbol
Name
ID
Adora1
adenosine A1 receptor
MGI:99401
Synonyms A1AR, A1-AR, A1R, AA1R, Ri
Feature Type protein coding gene
Genetic Map
Chromosome 1
58.15 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:134199223-134235431 bp, - strand
From Ensembl annotation of GRCm38

  36209 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20165  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: adenosine receptor
Gene Tree: Adora1

Human
homologs
Human Homolog ADORA1, adenosine A1 receptor
NCBI Gene ID 134
neXtProt AC  NX_P30542
Human Synonyms  RDC7
Human Chr (Location)  1q32.1; chr1:203127705-203167405 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show anxiety, hyperalgesia, allodynia and altered neuronal and brainstem respiratory activity upon hypoxia. Homozygotes for another null allele are susceptible to renal reperfusion injury, and lack tubuloglomerular feedback responses and 5'-AMP-induced bradycardia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process activation of MAPKK activity, adenosine receptor signaling pathway, ...
Component asymmetric synapse, axolemma, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled adenosine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (99)    Tissues (50)    Images (2)
Theiler Stages: 12, 14, 18, 21, 23, 25, 28
Assay TypeResults
RT-PCR 99
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000042429 (Evidence)
Entrez Gene11539 (Evidence)
NIA Mouse Gene IndexU021783
Consensus CDS ProjectCCDS15305.1
International Mouse Knockout Project StatusAdora1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042429 Ensembl Gene Model | MGI Sequence Detail 36209 C57BL/6J ±  kb
transcript ENSMUST00000086465 Ensembl | MGI Sequence Detail 4970 Not Applicable 
polypeptide ENSMUSP00000083656 Ensembl | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(13) UniProt(8)
Polymorphisms SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001068 Adenosine A1 receptor
InterPro IPR001634 Adenosine receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001575 adenosine receptor A1
References (Earliest) J:17705 Marquardt DL, et al., Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J Immunol. 1994 May 1;152(9):4508-15
(Latest) J:204608 Zhou X, et al., A1 adenosine receptor negatively modulates coronary reactive hyperemia via counteracting A2A-mediated H2O2 production and KATP opening in isolated mouse hearts. Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1668-79
All references(151)
Other
accession IDs
MGD-MRK-16162, MGI:2138349, MGI:2138644

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory