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Rpl22 Gene Detail
Summary
  • Symbol
    Rpl22
  • Name
    ribosomal protein L22
  • Synonyms
    2700038K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99262
    NCBI Gene: 19934
  • Gene Overview
    MyGene.info: RPL22
Location & Maps
more
  • Sequence Map
    Chr4:152325742-152334071 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8330 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.03 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RPL22, ribosomal protein L22
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RPL22, ribosomal protein L22
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EAP, HBP15, HBP15/L22, L22
  • Links
    NCBI Gene ID: 6146
    neXtProt AC: NX_P35268

  • Chr Location
    1p36.31; chr1:6185020-6199619 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    131
  • Gene trapped
    125
  • Targeted
    6
  • Genomic Mutations
    3 involving Rpl22
Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010577 VEGA Gene Model | MGI Sequence Detail 8330 C57BL/6J ±  kb
transcript OTTMUST00000024647 VEGA | MGI Sequence Detail 2051 Not Applicable  
polypeptide OTTMUSP00000011322 VEGA | MGI Sequence Detail 128 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014201 60S ribosomal protein L22
  • InterPro Domains
    IPR002671 Ribosomal protein L22e
Molecular
Reagents
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  • All nucleic 17
    cDNA 17

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16021, MGI:1914433
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
  • Latest
    J:230661 Gabanyi I, et al., Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell. 2016 Jan 28;164(3):378-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory