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Rpl22
Gene Detail
Symbol

Name
ID
Rpl22
ribosomal protein L22
MGI:99262
Synonyms
2700038K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
83.03 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:152325742-152334071 bp, + strand
From VEGA annotation of GRCm38

  8330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: RPL22
Protein SuperFamily: ribosomal protein L22
Gene Tree: Rpl22

Human
homologs
RPL22, ribosomal protein L22
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6146
neXtProt AC: NX_P35268

Human Synonyms: EAP, HBP15, HBP15/L22, L22

Human Chr (Location): 1p36.31; chr1:6185020-6199619 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(131) : Gene trapped(125) Targeted(6)
Genomic Mutations involving Rpl22 (3)
 
Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.
 
Interactions
Rpl22 interacts with 209 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process alpha-beta T cell differentiation, translation
Component cytoplasm, cytosolic large ribosomal subunit, ...
Function heparin binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rpl22 ; ZFIN rpl22    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000010577 (Evidence)
Ensembl Gene Model ENSMUSG00000028936 (Evidence)
Entrez Gene 19934 (Evidence)
DFCI TC1573986, TC1712195
DoTS DT.101206516, DT.102558907, DT.536833
NIA Mouse Gene Index U005168
Consensus CDS Project CCDS18999.1
International Mouse Phenotyping Consortium Status Rpl22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010577 VEGA Gene Model | MGI Sequence Detail 8330 C57BL/6J ±  kb
transcript OTTMUST00000024646 VEGA | MGI Sequence Detail 474 Not Applicable 
polypeptide OTTMUSP00000011321 VEGA | MGI Sequence Detail 128 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002671 Ribosomal protein L22e
Protein Ontology PR:000014201 60S ribosomal protein L22
References
(Earliest) J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
(Latest) J:218337 Hoffmann HM, et al., Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct;155(10):4043-53
All references(50)
Other
accession IDs
MGD-MRK-16021, MGI:1914433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory