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Rpl22
Gene Detail
Symbol

Name
ID
Rpl22
ribosomal protein L22
MGI:99262
Synonyms
2700038K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
83.03 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:152325742-152334071 bp, + strand
From VEGA annotation of GRCm38

  8330 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ribosomal protein L22
Gene Tree: Rpl22

Human
homologs
Human Homolog RPL22, ribosomal protein L22
NCBI Gene ID 6146
neXtProt AC  NX_P35268
Human Synonyms  EAP, HBP15, HBP15/L22, L22
Human Chr (Location)  1p36.31; chr1:6185020-6199619 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(130) : Gene trapped(125) Targeted(5)
Genomic Mutations involving Rpl22 (2)
 
Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.
 
Interactions
Rpl22 interacts with 209 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process alpha-beta T cell differentiation, translation
Component cytoplasm, cytosolic large ribosomal subunit, ...
Function heparin binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000010577 (Evidence)
Ensembl Gene ModelENSMUSG00000028936 (Evidence)
Entrez Gene19934 (Evidence)
DFCITC1573986, TC1712195
DoTSDT.101206516, DT.102558907, DT.536833
NIA Mouse Gene IndexU005168
Consensus CDS ProjectCCDS18999.1
International Mouse Knockout Project StatusRpl22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010577 VEGA Gene Model | MGI Sequence Detail 8330 C57BL/6J ±  kb
transcript OTTMUST00000024646 VEGA | MGI Sequence Detail 474 Not Applicable 
polypeptide OTTMUSP00000011321 VEGA | MGI Sequence Detail 128 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002671 Ribosomal protein L22e
Protein Ontology PR:000014201 60S ribosomal protein L22
References
(Earliest) J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
(Latest) J:214381 Spiegel I, et al., Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs. Cell. 2014 May 22;157(5):1216-29
All references(49)
Other
accession IDs
MGD-MRK-16021, MGI:1914433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory