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Rpl22 Gene Detail
Summary
  • Symbol
    Rpl22
  • Name
    ribosomal protein L22
  • Synonyms
    2700038K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99262
    NCBI Gene: 19934
  • Gene Overview
    MyGene.info: RPL22
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:152325742-152334071 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.03 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99262
protein coding gene Chr4:152324436-152334082 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029180
protein coding gene Chr4:156438480-156447394 (+)
A/J MGP_AJ_G0029145
protein coding gene Chr4:149885048-149893497 (+)
AKR/J MGP_AKRJ_G0029093
protein coding gene Chr4:153954572-153962901 (+)
BALB/cJ MGP_BALBcJ_G0029161
protein coding gene Chr4:150351687-150360016 (+)
C3H/HeJ MGP_C3HHeJ_G0028882
protein coding gene Chr4:154521666-154531537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029610
protein coding gene Chr4:162051097-162059426 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026856
protein coding gene Chr4:142224498-142233194 (+)
CAST/EiJ MGP_CASTEiJ_G0028295
protein coding gene Chr4:151873586-151882002 (+)
CBA/J MGP_CBAJ_G0028844
protein coding gene Chr4:166883961-166892290 (+)
DBA/2J MGP_DBA2J_G0028993
protein coding gene Chr4:149936815-149945144 (+)
FVB/NJ MGP_FVBNJ_G0028957
protein coding gene Chr4:149099015-149107344 (+)
LP/J MGP_LPJ_G0029083
protein coding gene Chr4:156365967-156374296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028984
protein coding gene Chr4:169893287-169902252 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029642
protein coding gene Chr4:154493886-154502215 (+)
PWK/PhJ MGP_PWKPhJ_G0028015
protein coding gene Chr4:146004546-146012960 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027849
protein coding gene Chr4:148780880-148790687 (+)
WSB/EiJ MGP_WSBEiJ_G0028375
protein coding gene Chr4:154681720-154691930 (+)



Homology
more
  • Human Ortholog
    RPL22, ribosomal protein L22
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RPL22, ribosomal protein L22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAP, HBP15, HBP15/L22, L22
  • Links
    NCBI Gene ID: 6146
    neXtProt AC: NX_P35268
    UniProt: P35268

  • Chr Location
    1p36.31; chr1:6185020-6199619 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028936 Ensembl Gene Model | MGI Sequence Detail 8330 C57BL/6J ±  kb
transcript ENSMUST00000103191 Ensembl | MGI Sequence Detail 474 Not Applicable  
polypeptide ENSMUSP00000099480 Ensembl | MGI Sequence Detail 128 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16021, MGI:1914433
References
more
  • Summaries
    All 114
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 85
  • Earliest
    J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
  • Latest
    J:277817 Dieguez-Hurtado R, et al., Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019 Jun 27;10(1):2817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory