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Ptgds Gene Detail
Summary
  • Symbol
    Ptgds
  • Name
    prostaglandin D2 synthase (brain)
  • Synonyms
    L-PGDS, PGD2, Ptgs3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99261
    NCBI Gene: 19215
  • Gene Overview
    MyGene.info: PTGDS
Location & Maps
more
  • Sequence Map
    Chr2:25466709-25470046 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3338 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.28 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PTGDS, prostaglandin D2 synthase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PTGDS, prostaglandin D2 synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LPGDS, L-PGDS, PDS, PGD2, PGDS, PGDS2
  • Links
    NCBI Gene ID: 5730
    neXtProt AC: NX_P41222

  • Chr Location
    9q34.2-q34.3; chr9:136977504-136981742 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    2
  • Targeted
    6
  • Transgenic
    2
  • Incidental Mutations
Mice homozygous for one knock-out allele fail to exhibit PGE2- and bicuculline-induced allodynia and exhibit decreased susceptibility to IgE-induced PCA. Mice homozygous for another knock-out allele show normal induction of muscle injury after reperfusion of ischemic skeletal muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012118 VEGA Gene Model | MGI Sequence Detail 3338 C57BL/6J ±  kb
transcript OTTMUST00000028912 VEGA | MGI Sequence Detail 830 Not Applicable  
polypeptide OTTMUSP00000013067 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    124 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    cDNA 92
    Primer pair 6
    Other 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13666, MGD-MRK-16020
References
more
  • Summaries
    All 110
    Developmental Gene Expression 42
    Gene Ontology 8
    Phenotypes 29
  • Earliest
    J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
  • Latest
    J:232147 Isbel L, et al., Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. PLoS Genet. 2015 Dec;11(12):e1005693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory