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Matk Gene Detail
Summary
  • Symbol
    Matk
  • Name
    megakaryocyte-associated tyrosine kinase
  • Synonyms
    CHK, Csk homologous kinase, HYL, Ntk
  • Feature Type
    protein coding gene
  • IDs
    MGI:99259
    NCBI Gene: 17179
Location & Maps
more
  • Sequence Map
    Chr10:81252935-81263365 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10431 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    MATK, megakaryocyte-associated tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MATK, megakaryocyte-associated tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHK, CTK, HHYLTK, HYL, HYLTK, Lsk
  • Links
    NCBI Gene ID: 4145
    neXtProt AC: NX_P42679

  • Chr Location
    19p13.3; chr19:3777969-3801812 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Matk
  • Incidental Mutations
Homozygous mice are viable and fertile and appear normal. Unchallenged mutant mice exhibit no hematopoietic defects. SPKLS cell numbers are elevated. IL-7 induced BM cell proliferation and pre-B cell colony formation are enhanced. Antigen induced IFN-gamma secretion is reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030346 VEGA Gene Model | MGI Sequence Detail 10431 C57BL/6J ±  kb
transcript OTTMUST00000075185 VEGA | MGI Sequence Detail 1980 Not Applicable  
polypeptide OTTMUSP00000039351 VEGA | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 36
    Genomic 5
    cDNA 30
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16018
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:18624 Chow LM, et al., Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4975-9
  • Latest
    J:177766 Lindquist S, et al., Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One. 2011;6(9):e23978

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory