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Matk
Gene Detail
Symbol

Name
ID
Matk
megakaryocyte-associated tyrosine kinase
MGI:99259
Synonyms
CHK, Csk homologous kinase, HYL, Ntk
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:81252935-81263365 bp, + strand
From VEGA annotation of GRCm38

  10431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MATK
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Matk

Human
homologs
MATK, megakaryocyte-associated tyrosine kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4145
neXtProt AC: NX_P42679

Human Synonyms: CHK, CTK, HHYLTK, HYL, HYLTK, Lsk

Human Chr (Location): 19p13.3; chr19:3777969-3801812 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice are viable and fertile and appear normal. Unchallenged mutant mice exhibit no hematopoietic defects. SPKLS cell numbers are elevated. IL-7 induced BM cell proliferation and pre-B cell colony formation are enhanced. Antigen induced IFN-gamma secretion is reduced.
 
Interactions
Matk interacts with 173 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell differentiation, cell migration, ...
Component cytoplasm, extrinsic component of cytoplasmic side of plasma membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (13)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 1
Western blot 3
RT-PCR 9
RNase protection 14
cDNA source data(26)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN matk    NEW 
Molecular
reagents
All nucleic(36) Genomic(5) cDNA(30) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030346 (Evidence)
Ensembl Gene Model ENSMUSG00000004933 (Evidence)
Entrez Gene 17179 (Evidence)
UniGene 2918
DFCI TC1578923, TC1590820, TC1672758, TC1718755, TC1731779
DoTS DT.101170075, DT.101288093, DT.101370863, DT.101370866, DT.110598521, DT.55180508, DT.91284210
NIA Mouse Gene Index U011776
EC 2.7.10.2
Consensus CDS Project CCDS24048.1, CCDS70077.1, CCDS70078.1
International Mouse Phenotyping Consortium Status Matk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030346 VEGA Gene Model | MGI Sequence Detail 10431 C57BL/6J ±  kb
transcript OTTMUST00000075185 VEGA | MGI Sequence Detail 1980 Not Applicable 
polypeptide OTTMUSP00000039351 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(22) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000010204 megakaryocyte-associated tyrosine-protein kinase
References
(Earliest) J:18624 Chow LM, et al., Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4975-9
(Latest) J:177766 Lindquist S, et al., Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One. 2011;6(9):e23978
All references(43)
Other
accession IDs
MGD-MRK-16018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory