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Eif3e Gene Detail
Summary
  • Symbol
    Eif3e
  • Name
    eukaryotic translation initiation factor 3, subunit E
  • Synonyms
    48kDa, eIF3-p46, eIF3-p48, Eif3s6, Int6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99257
    NCBI Gene: 16341
  • Gene Overview
    MyGene.info: EIF3E
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43250058-43282719 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.73 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99257
protein coding gene Chr15:43250040-43282736 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021825
protein coding gene Chr15:41832975-41865605 (-)
A/J MGP_AJ_G0021785
protein coding gene Chr15:40228854-40261558 (-)
AKR/J MGP_AKRJ_G0021766
protein coding gene Chr15:41436646-41469346 (-)
BALB/cJ MGP_BALBcJ_G0021792
protein coding gene Chr15:40308062-40340756 (-)
C3H/HeJ MGP_C3HHeJ_G0021566
protein coding gene Chr15:41338361-41371059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022231
protein coding gene Chr15:43446742-43479438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019768
protein coding gene Chr15:37822398-37855372 (-)
CAST/EiJ MGP_CASTEiJ_G0021083
protein coding gene Chr15:41876068-41908823 (-)
CBA/J MGP_CBAJ_G0021535
protein coding gene Chr15:44954365-44991306 (-)
DBA/2J MGP_DBA2J_G0021659
protein coding gene Chr15:40061555-40094385 (-)
FVB/NJ MGP_FVBNJ_G0021637
protein coding gene Chr15:39380169-39412861 (-)
LP/J MGP_LPJ_G0021729
protein coding gene Chr15:41622246-41654876 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021661
protein coding gene Chr15:48053912-48095063 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022254
protein coding gene Chr15:41625318-41659817 (-)
PWK/PhJ MGP_PWKPhJ_G0020828
protein coding gene Chr15:40093814-40127493 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020665
protein coding gene Chr15:41276387-41309640 (-)
WSB/EiJ MGP_WSBEiJ_G0021138
protein coding gene Chr15:41508128-41540859 (-)



Homology
more
  • Human Ortholog
    EIF3E, eukaryotic translation initiation factor 3 subunit E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF3E, eukaryotic translation initiation factor 3 subunit E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    eIF3-p46, EIF3-P48, EIF3S6, INT6
  • Links
    NCBI Gene ID: 3646
    neXtProt AC: NX_P60228
    UniProt: P60228

  • Chr Location
    8q23.1; chr8:108201743-108248802 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022336 Ensembl Gene Model | MGI Sequence Detail 32662 C57BL/6J ±  kb
transcript ENSMUST00000022960 Ensembl | MGI Sequence Detail 1506 Not Applicable  
polypeptide ENSMUSP00000022960 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006977 eukaryotic translation initiation factor 3 subunit E
  • InterPro Domains
    IPR016650 Eukaryotic translation initiation factor 3 subunit E
    IPR019010 Eukaryotic translation initiation factor 3 subunit E, N-terminal
    IPR000717 Proteasome component (PCI) domain
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 28
    Genomic 8
    cDNA 20

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16016
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:265010 Sadato D, et al., Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation. FEBS Open Bio. 2018 Aug;8(8):1188-1201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory