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Eif3e Gene Detail
Summary
  • Symbol
    Eif3e
  • Name
    eukaryotic translation initiation factor 3, subunit E
  • Synonyms
    48kDa, eIF3-p46, eIF3-p48, Eif3s6, Int6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99257
    NCBI Gene: 16341
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43113454-43146115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.73 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99257
 protein coding gene Chr15:43113436-43146132 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021825
 protein coding gene Chr15:41832975-41865605 (-)
A/J MGP_AJ_G0021785
 protein coding gene Chr15:40228854-40261558 (-)
AKR/J MGP_AKRJ_G0021766
 protein coding gene Chr15:41436646-41469346 (-)
BALB/cJ MGP_BALBcJ_G0021792
 protein coding gene Chr15:40308062-40340756 (-)
C3H/HeJ MGP_C3HHeJ_G0021566
 protein coding gene Chr15:41338361-41371059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022231
 protein coding gene Chr15:43446742-43479438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019768
 protein coding gene Chr15:37822398-37855372 (-)
CAST/EiJ MGP_CASTEiJ_G0021083
 protein coding gene Chr15:41876068-41908823 (-)
CBA/J MGP_CBAJ_G0021535
 protein coding gene Chr15:44954365-44991306 (-)
DBA/2J MGP_DBA2J_G0021659
 protein coding gene Chr15:40061555-40094385 (-)
FVB/NJ MGP_FVBNJ_G0021637
 protein coding gene Chr15:39380169-39412861 (-)
LP/J MGP_LPJ_G0021729
 protein coding gene Chr15:41622246-41654876 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021661
 protein coding gene Chr15:48053912-48095063 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022254
 protein coding gene Chr15:41625318-41659817 (-)
PWK/PhJ MGP_PWKPhJ_G0020828
 protein coding gene Chr15:40093814-40127493 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020665
 protein coding gene Chr15:41276387-41309640 (-)
WSB/EiJ MGP_WSBEiJ_G0021138
 protein coding gene Chr15:41508128-41540859 (-)



Homology
more
  • Human Ortholog
    EIF3E, eukaryotic translation initiation factor 3 subunit E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF3E, eukaryotic translation initiation factor 3 subunit E
  • Synonyms
    eIF3-p46, EIF3-P48, EIF3S6, INT6
  • Links
    NCBI Gene ID: 3646
    neXtProt AC: NX_P60228
    UniProt: P60228

  • Chr Location
    8q23.1; chr8:108162787-108443496 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit prenatal lethality with reduced embryo size, cell size and fetal membranes. Mice heterozygous for a null allele exhibit reduced size, weight, MEF cell proliferation and MEF translation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    28
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022336 Ensembl Gene Model | MGI Sequence Detail 32662 C57BL/6J ±  kb
    transcript ENSMUST00000022960 Ensembl | MGI Sequence Detail 1506 Not Applicable  
    polypeptide ENSMUSP00000022960 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006977 eukaryotic translation initiation factor 3 subunit E
      (term hierarchy)
    • InterPro Domains
      IPR016650 Eukaryotic translation initiation factor 3 subunit E
      IPR019010 Eukaryotic translation initiation factor 3 subunit E, N-terminal
      IPR000717 Proteasome component (PCI) domain
      IPR036390 Winged helix DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 8
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16016
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:314131 Fujii K, et al., Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Dev Cell. 2021 Nov 8;56(21):2928-2937.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory