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Etv1
Gene Detail
 Symbol
Name
ID
Etv1
ets variant 1
MGI:99254
Synonyms ER81, Etsrp81
Feature Type protein coding gene
Genetic Map
Chromosome 12
17.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:38779380-38868215 bp, + strand
From VEGA annotation of GRCm38

  88836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor ER81
Gene Tree: Etv1

Human
homologs
Human Homolog ETV1, ets variant 1
NCBI Gene ID 2115
neXtProt AC  NX_P50549
Human Synonyms  ER81
Human Chr (Location)  7p21.3; chr7:13891229-13991425 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(7) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to premature death, ataxia, impaired limb coordination, defects in muscle innervation, muscle spindle differentiation and sensory-motor connectivity, deficient golgi tendon organs, and absence of Pacinian corpuscles and their afferents.
 
Interactions
Etv1 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process axon guidance, mechanosensory behavior, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (155 records)
Data Summary: Results (280)    Tissues (247)    Images (39)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 240
In situ reporter (knock in) 10
Northern blot 21
RT-PCR 9
cDNA source data(52)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(54) Primer pair(6) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035098 (Evidence)
Ensembl Gene ModelENSMUSG00000004151 (Evidence)
Entrez Gene14009 (Evidence)
UniGene4866
DFCITC1576141, TC1584683
DoTSDT.103586692, DT.55255096, DT.91344039, DT.91374387
Consensus CDS ProjectCCDS49053.1, CCDS49054.1
International Mouse Knockout Project StatusEtv1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035098 VEGA Gene Model | MGI Sequence Detail 88836 C57BL/6J ±  kb
transcript OTTMUST00000089277 VEGA | MGI Sequence Detail 4307 Not Applicable 
polypeptide OTTMUSP00000048763 VEGA | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(22) UniProt(11)
Polymorphisms PCR(1) : SNPs within 2kb(593 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007223 ETS translocation variant 1
References (Earliest) J:19172 Brown TA, et al., Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992 Dec;6(12B):2502-12
(Latest) J:208651 Louvi A, et al., Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
All references(204)
Other
accession IDs
MGD-MRK-16012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory