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Etv1
Gene Detail
Symbol

Name
ID
Etv1
ets variant 1
MGI:99254
Synonyms
ER81, Etsrp81
Feature Type
protein coding gene
Genetic Map
Chromosome 12
17.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:38779380-38868215 bp, + strand
From VEGA annotation of GRCm38

  88836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ETV1
Protein SuperFamily: transcription factor ER81
Gene Tree: Etv1

Human
homologs
ETV1, ets variant 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2115
neXtProt AC: NX_P50549

Human Synonyms: ER81

Human Chr (Location): 7p21.3; chr7:13891229-13991425 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(7) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to premature death, ataxia, impaired limb coordination, defects in muscle innervation, muscle spindle differentiation and sensory-motor connectivity, deficient golgi tendon organs, and absence of Pacinian corpuscles and their afferents.
 
Interactions
Etv1 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process axon guidance, cell differentiation, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (168 records)
Data Summary: Results (316)    Tissues (258)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 276
In situ reporter (knock in) 10
Northern blot 21
RT-PCR 9
cDNA source data(54)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ETV1 ; Xenbase etv1 ; ZFIN etv1    NEW 
Molecular
reagents
All nucleic(65) cDNA(57) Primer pair(6) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000035098 (Evidence)
Ensembl Gene Model ENSMUSG00000004151 (Evidence)
Entrez Gene 14009 (Evidence)
UniGene 4866
DFCI TC1576141, TC1584683
DoTS DT.103586692, DT.55255096, DT.91344039, DT.91374387
NIA Mouse Gene Index U013878, U046781, U061800
Consensus CDS Project CCDS49053.1, CCDS49054.1
International Mouse Phenotyping Consortium Status Etv1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035098 VEGA Gene Model | MGI Sequence Detail 88836 C57BL/6J ±  kb
transcript OTTMUST00000089277 VEGA | MGI Sequence Detail 4307 Not Applicable 
polypeptide OTTMUSP00000048763 VEGA | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(22) UniProt(11)
Polymorphisms
PCR(1) : SNPs within 2kb(593 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007223 ETS translocation variant 1
References
(Earliest) J:19172 Brown TA, et al., Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992 Dec;6(12B):2502-12
(Latest) J:220379 Oka Y, et al., Thirst driving and suppressing signals encoded by distinct neural populations in the brain. Nature. 2015 Apr 16;520(7547):349-52
All references(219)
Other
accession IDs
MGD-MRK-16012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory