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Etv1 Gene Detail
Summary
  • Symbol
    Etv1
  • Name
    ets variant 1
  • Synonyms
    ER81, Etsrp81
  • Feature Type
    protein coding gene
  • IDs
    MGI:99254
    NCBI Gene: 14009
  • Gene Overview
    MyGene.info: ETV1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:38779656-38868215 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 17.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    590 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99254
protein coding gene Chr12:38779380-38870484 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019698
protein coding gene Chr12:37103158-37198363 (+)
A/J MGP_AJ_G0019664
protein coding gene Chr12:35901164-35991637 (+)
AKR/J MGP_AKRJ_G0019635
protein coding gene Chr12:37015821-37105115 (+)
BALB/cJ MGP_BALBcJ_G0019642
protein coding gene Chr12:36138640-36228270 (+)
C3H/HeJ MGP_C3HHeJ_G0019446
protein coding gene Chr12:36928173-37021262 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020089
protein coding gene Chr12:38245448-38338703 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017714
protein coding gene Chr12:34961077-35049581 (+)
CAST/EiJ MGP_CASTEiJ_G0018999
protein coding gene Chr12:32076109-32168496 (+)
CBA/J MGP_CBAJ_G0019418
protein coding gene Chr12:39493656-39585951 (+)
DBA/2J MGP_DBA2J_G0019531
protein coding gene Chr12:35779557-35870883 (+)
FVB/NJ MGP_FVBNJ_G0019520
protein coding gene Chr12:35451374-35540909 (+)
LP/J MGP_LPJ_G0019601
protein coding gene Chr12:37175356-37263789 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019556
protein coding gene Chr12:39534977-39628815 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020129
protein coding gene Chr12:36574720-36666785 (+)
PWK/PhJ MGP_PWKPhJ_G0018766
protein coding gene Chr12:30443838-30533921 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018556
protein coding gene Chr12:31216136-31306039 (+)
WSB/EiJ MGP_WSBEiJ_G0019049
protein coding gene Chr12:36858240-36949782 (+)



Homology
more
  • Human Ortholog
    ETV1, ETS variant 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ETV1, ETS variant 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ER81
  • Links
    NCBI Gene ID: 2115
    neXtProt AC: NX_P50549
    UniProt: P50549

  • Chr Location
    7p21.2; chr7:13891229-13991425 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 6 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to premature death, ataxia, impaired limb coordination, defects in muscle innervation, muscle spindle differentiation and sensory-motor connectivity, deficient golgi tendon organs, and absence of Pacinian corpuscles and their afferents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14009 NCBI Gene Model | MGI Sequence Detail 88560 C57BL/6J ±  kb
    transcript NM_007960 RefSeq | MGI Sequence Detail 4322 C57BL/6  
    polypeptide P41164 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR000418 Ets domain
      IPR032928 ETS translocation variant 1
      IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 57
      Primer pair 6
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16012
    References
    more
    • Summaries
      All 260
      Developmental Gene Expression 203
      Gene Ontology 7
      Phenotypes 32
    • Earliest
      J:19172 Brown TA, et al., Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992 Dec;6(12B):2502-12
    • Latest
      J:267072 Newton K, et al., Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11244-11249

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    01/08/2019
    MGI 6.13
    The Jackson Laboratory