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Egr4
Gene Detail
Symbol

Name
ID
Egr4
early growth response 4
MGI:99252
Synonyms
NGF1-C, NGFI-C, pAT133
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:85511122-85513542 bp, - strand
From NCBI annotation of GRCm38

  2421 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: EGR4
Gene Tree: Egr4

Human
homologs
EGR4, early growth response 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1961
neXtProt AC: NX_Q05215

Human Synonyms: NGFIC, NGFI-C, PAT133

Human Chr (Location): 2p13; chr2:73290929-73293701 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Genomic Mutations involving Egr4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Male homozygous null mice are viable but infertile due to an impairment of meiosis during spermatogenesis. Females are fertile and the gross anatomy of both sexes appears normal.
 
Interactions
Egr4 interacts with 68 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to cAMP, cellular response to gonadotropin stimulus, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (73)    Tissues (50)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EGR4 ; Xenbase egr4    NEW 
Molecular
reagents
All nucleic(7) cDNA(6) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000071341 (Evidence)
Entrez Gene 13656 (Evidence)
UniGene 44137
DFCI TC1586010
DoTS DT.60100278
NIA Mouse Gene Index U027555
Consensus CDS Project CCDS20297.1
International Mouse Phenotyping Consortium Status Egr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13656 NCBI Gene Model | MGI Sequence Detail 2421 C57BL/6J ±  kb
transcript NM_020596 RefSeq | MGI Sequence Detail 2100 C57BL/6 
polypeptide Q9WUF2 UniProt | EBI | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000006940 early growth response protein 4
Graphical View of Protein Domain Structure
References
(Earliest) J:1017 Crosby SD, et al., Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C [published erratum appears in Proc Natl Acad Sci U S A 1992 Jul 15;89(14):6663]. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4739-43
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)
Other
accession IDs
MGD-MRK-16010

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory