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Egr4 Gene Detail
Summary
  • Symbol
    Egr4
  • Name
    early growth response 4
  • Synonyms
    NGF1-C, NGFI-C, pAT133
  • Feature Type
    protein coding gene
  • IDs
    MGI:99252
    NCBI Gene: 13656
  • Gene Overview
    MyGene.info: EGR4
Location & Maps
more
  • Sequence Map
    Chr6:85511121-85513589 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2469 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.48 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EGR4, early growth response 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EGR4, early growth response 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NGFIC, NGFI-C, PAT133
  • Links
    NCBI Gene ID: 1961
    neXtProt AC: NX_Q05215

  • Chr Location
    2p13; chr2:73290929-73293701 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1485
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: EGR4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Egr4
  • Incidental Mutations
Male homozygous null mice are viable but infertile due to an impairment of meiosis during spermatogenesis. Females are fertile and the gross anatomy of both sexes appears normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055994 VEGA Gene Model | MGI Sequence Detail 2469 C57BL/6J ±  kb
transcript OTTMUST00000138489 VEGA | MGI Sequence Detail 2148 Not Applicable  
polypeptide OTTMUSP00000072804 VEGA | MGI Sequence Detail 478 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006940 early growth response protein 4
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16010
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:1017 Crosby SD, et al., Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C [published erratum appears in Proc Natl Acad Sci U S A 1992 Jul 15;89(14):6663]. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4739-43
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory