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Cdh4 Gene Detail
Summary
  • Symbol
    Cdh4
  • Name
    cadherin 4
  • Synonyms
    Rcad, R-Cadh, R-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:99218
    NCBI Gene: 12561
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179084228-179541166 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 101.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12768 from dbSNP Build 142
  • Strain Annotations
    31
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99218
 protein coding gene Chr2:179084224-179541166 (+)
129S1/SvImJ ENSMUSG00200001547
 protein coding gene Chr2:175109796-175565812 (+)
129S1/SvImJ ENSMUSG00200001583
 protein coding gene Chr2:175560340-175561124 (+)
A/J ENSMUSG00195001051
 protein coding gene Chr2:175797591-175798375 (+)
A/J ENSMUSG00195001050
 protein coding gene Chr2:175347061-175803063 (+)
AKR/J ENSMUSG00220000086
 protein coding gene Chr2:173476196-173476980 (+)
AKR/J ENSMUSG00220000085
 protein coding gene Chr2:173024177-173481668 (+)
BALB/cJ ENSMUSG00180000226
 protein coding gene Chr2:173149183-173605190 (+)
BALB/cJ ENSMUSG00180000229
 protein coding gene Chr2:173599717-173600501 (+)
C3H/HeJ ENSMUSG00175004218
 protein coding gene Chr2:174307678-174764239 (+)
C3H/HeJ ENSMUSG00175004219
 protein coding gene Chr2:174758774-174759558 (+)
C57BL/6NJ ENSMUSG00215002562
 protein coding gene Chr2:173244363-173701878 (+)
C57BL/6NJ ENSMUSG00215002566
 protein coding gene Chr2:173696414-173697198 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024768
 protein coding gene Chr2:168954405-169422684 (+)
CAST/EiJ ENSTCUG00005000478
 protein coding gene Chr2:172598524-173053757 (+)
CBA/J ENSMUSG00210000747
 protein coding gene Chr2:173627314-174083298 (+)
CBA/J ENSMUSG00210000757
 protein coding gene Chr2:174077826-174078610 (+)
DBA/2J ENSMUSG00185019419
 protein coding gene Chr2:175318178-175318962 (+)
DBA/2J ENSMUSG00185019405
 protein coding gene Chr2:174867076-175323642 (+)
FVB/NJ ENSMUSG00205002235
 protein coding gene Chr2:173674625-174130922 (+)
FVB/NJ ENSMUSG00205002237
 protein coding gene Chr2:174125450-174126234 (+)
JF1/MsJ ENSUMUG00000013461
 protein coding gene Chr2:176041220-176503122 (+)
LP/J ENSMUSG00230023754
 protein coding gene Chr2:176760836-177216800 (+)
LP/J ENSMUSG00230023816
 protein coding gene Chr2:177211328-177212112 (+)
NOD/ShiLtJ ENSMUSG00190016075
 protein coding gene Chr2:173168940-173624913 (+)
NOD/ShiLtJ ENSMUSG00190016089
 protein coding gene Chr2:173619441-173620225 (+)
NZO/HlLtJ ENSMUSG00225006444
 protein coding gene Chr2:184847711-185304256 (+)
NZO/HlLtJ ENSMUSG00225006488
 protein coding gene Chr2:185298792-185299576 (+)
PWK/PhJ ENSLUMG00010032762
 protein coding gene Chr2:173465392-173927645 (+)
SPRET/EiJ ENSMSPG00010003675
 protein coding gene Chr2:175949174-176404286 (+)
WSB/EiJ ENSIUOG00005000193
 protein coding gene Chr2:173192928-173648922 (+)



Homology
more
  • Human Ortholog
    CDH4, cadherin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH4, cadherin 4
  • Synonyms
    CAD4, R-CAD, RCAD
  • Links
    NCBI Gene ID: 1002
    UniProt: P55283

  • Chr Location
    20q13.33; chr20:61252261-61940617 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in dilation of the proximal renal tubules and extensive vacuolization of tubule epithelium. Uretic bud epithelium appear disorganized and exhibit increased apoptosis at E15.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1266
  • Tissues
    432
  • cDNA Data
    50
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12561 NCBI Gene Model | MGI Sequence Detail 456939 C57BL/6J ±  kb
    transcript NM_001416935 RefSeq | MGI Sequence Detail 7442 ZRU/MplStud  
    polypeptide P39038 UniProt | EBI | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 51
      Primer pair 5
      Other 4
      Antibodies 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15975, MGD-MRK-19361, MGI:2139310
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 62
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:2587 Moller CJ, et al., Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol. 1992 Aug;6(8):1332-42
    • Latest
      J:372021 Prakash A, et al., Coupling between spatial compartments integrates morphogenetic patterning in the organ of Corti. PLoS Biol. 2025 Sep;23(9):e3003350
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory