About   Help   FAQ
Cdh11
Gene Detail
Symbol

Name
ID
Cdh11
cadherin 11
MGI:99217
Synonyms
Cad11, OB-cadherin, osteoblast-cadherin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
50.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:102632995-102785111 bp, - strand
From Ensembl annotation of GRCm38

  152117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDH11
Protein SuperFamily: cadherin
Gene Tree: Cdh11

Human
homologs
CDH11, cadherin 11, type 2, OB-cadherin (osteoblast)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1009
neXtProt AC: NX_P55287

Human Synonyms: CAD11, CDHOB, OB, OSF-4

Human Chr (Location): 16q21; chr16:64945226-65126112 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant animals appear healthy and fertile.
 
Interactions
Cdh11 interacts with 313 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, corticospinal tract morphogenesis, ...
Component cytoplasm, extracellular exosome, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (485)    Tissues (382)    Images (102)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 409
Northern blot 15
Western blot 3
RT-PCR 55
cDNA source data(88)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CDH11 ; Xenbase cdh11 ; ZFIN cdh11    NEW 
Molecular
reagents
All nucleic(109) Genomic(2) cDNA(96) Primer pair(6) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031673 (Evidence)
Entrez Gene 12552 (Evidence)
UniGene 1571
DoTS DT.40179413, DT.91559337, DT.94408624
PDB 2A4C, 2A4E
Consensus CDS Project CCDS22571.1
International Mouse Phenotyping Consortium Status Cdh11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031673 Ensembl Gene Model | MGI Sequence Detail 152117 C57BL/6J ±  kb
transcript ENSMUST00000075190 Ensembl | MGI Sequence Detail 4216 Not Applicable 
polypeptide ENSMUSP00000074681 Ensembl | MGI Sequence Detail 796 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(1072 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000005230 cadherin-11
References
(Earliest) J:17789 Okazaki M, et al., Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem. 1994 Apr 22;269(16):12092-8
(Latest) J:214675 Alimperti S, et al., Cadherin-11 regulates both mesenchymal stem cell differentiation into smooth muscle cells and the development of contractile function in vivo. J Cell Sci. 2014 Jun 15;127(Pt 12):2627-38
All references(88)
Other
accession IDs
MGD-MRK-15974

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory