About   Help   FAQ
Cdh11
Gene Detail
Symbol

Name
ID
Cdh11
cadherin 11
MGI:99217
Synonyms
Cad11, OB-cadherin, osteoblast-cadherin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
50.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:102632995-102785111 bp, - strand
From NCBI annotation of GRCm38

  152117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh11

Human
homologs
Human Homolog CDH11, cadherin 11, type 2, OB-cadherin (osteoblast)
NCBI Gene ID 1009
neXtProt AC  NX_P55287
Human Synonyms  CAD11, CDHOB, OB, OSF-4
Human Chr (Location)  16q21; chr16:64882891-65126112 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant animals appear healthy and fertile.
 
Interactions
Cdh11 interacts with 313 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, corticospinal tract morphogenesis, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (485)    Tissues (378)    Images (102)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 409
Northern blot 15
Western blot 3
RT-PCR 55
cDNA source data(88)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) Genomic(2) cDNA(96) Primer pair(6) Other(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031673 (Evidence)
Entrez Gene12552 (Evidence)
UniGene1571
DoTSDT.40179413, DT.91559337, DT.94408624
PDB2A4C, 2A4E
Consensus CDS ProjectCCDS22571.1
International Mouse Knockout Project StatusCdh11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12552 NCBI Gene Model | MGI Sequence Detail 152117 C57BL/6J ±  kb
transcript NM_009866 RefSeq | MGI Sequence Detail 4216 C57BL/6 
polypeptide P55288 UniProt | EBI | MGI Sequence Detail 796 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(1072 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000005230 cadherin-11
Graphical View of Protein Domain Structure
References
(Earliest) J:17789 Okazaki M, et al., Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem. 1994 Apr 22;269(16):12092-8
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(88)
Other
accession IDs
MGD-MRK-15974

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory