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Cdh11 Gene Detail
Summary
  • Symbol
    Cdh11
  • Name
    cadherin 11
  • Synonyms
    Cad11, OB-cadherin, osteoblast-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:99217
    NCBI Gene: 12552
  • Gene Overview
    MyGene.info: CDH11
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:102632095-102785493 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 50.44 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1064 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99217
protein coding gene Chr8:102632095-102785642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033997
protein coding gene Chr8:104502904-104685229 (-)
A/J MGP_AJ_G0033980
protein coding gene Chr8:100378535-100447086 (-)
AKR/J MGP_AKRJ_G0033906
protein coding gene Chr8:103280109-103480617 (-)
BALB/cJ MGP_BALBcJ_G0033972
protein coding gene Chr8:100612295-100784024 (-)
C3H/HeJ MGP_C3HHeJ_G0033683
protein coding gene Chr8:103973063-104150327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034494
protein coding gene Chr8:108398534-108472926 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031435
protein coding gene Chr8:93839263-93996701 (-)
CAST/EiJ MGP_CASTEiJ_G0033014
protein coding gene Chr8:103597567-103660562 (-)
CBA/J MGP_CBAJ_G0033658
protein coding gene Chr8:112012212-112202003 (-)
DBA/2J MGP_DBA2J_G0033812
protein coding gene Chr8:99817165-99998146 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033801
protein coding gene Chr8:115169564-115364549 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034511
protein coding gene Chr8:103336771-103520778 (-)
PWK/PhJ MGP_PWKPhJ_G0032716
protein coding gene Chr8:99231003-99408925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032553
protein coding gene Chr8:102184170-102301060 (-)
WSB/EiJ MGP_WSBEiJ_G0033126
protein coding gene Chr8:103929171-103990627 (-)



Homology
more
  • Human Ortholog
    CDH11, cadherin 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDH11, cadherin 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAD11, CDHOB, ESWS, OB, OSF-4
  • Links
    NCBI Gene ID: 1009
    neXtProt AC: NX_P55287
    UniProt: P55287

  • Chr Location
    16q21; chr16:64943753-65126112 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1361
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDH11
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CDH11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    18 phenotype references
Homozygous mutant animals appear healthy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12552 NCBI Gene Model | MGI Sequence Detail 153399 C57BL/6J ±  kb
transcript NM_009866 RefSeq | MGI Sequence Detail 5132 C57BL/6  
polypeptide P55288 UniProt | EBI | MGI Sequence Detail 796 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 114
    Genomic 2
    cDNA 99
    Primer pair 7
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15974
References
more
  • Summaries
    All 110
    Developmental Gene Expression 60
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:17789 Okazaki M, et al., Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem. 1994 Apr 22;269(16):12092-8
  • Latest
    J:290264 Vagnozzi AN, et al., Phrenic-specific transcriptional programs shape respiratory motor output. Elife. 2020 Jan 16;9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory