Ddr1 MGI Mouse Gene Detail - MGI:99216 - discoidin domain receptor family, member 1

Symbol

Ddr1
Name

discoidin domain receptor family, member 1
Synonyms

Cak, CD167a

Feature Type

protein coding gene
IDs

MGI:99216
NCBI Gene: 12305
Alliance

genome feature page
Transcription Start Sites

16 TSS

Sequence Map

Chr17:35992459-36015513 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.70 cM, cytoband C
Mapping Data

7 experiments

SNPs within 2kb

9 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99216	protein coding gene	Chr17:35992459-36015633 (-)
129S1/SvImJ	ENSMUSG00200047094	protein coding gene	Chr17:31622553-31645804 (-)
A/J	ENSMUSG00195045239	protein coding gene	Chr17:32685231-32708214 (-)
AKR/J	ENSMUSG00220038851	protein coding gene	Chr17:31486084-31509296 (-)
BALB/cJ	ENSMUSG00180032007	protein coding gene	Chr17:32055018-32078009 (-)
C3H/HeJ	ENSMUSG00175037879	protein coding gene	Chr17:31371894-31395124 (-)
C57BL/6NJ	ENSMUSG00215052419	protein coding gene	Chr17:31442966-31466032 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021531	protein coding gene	Chr17:32457152-32479957 (-)
CAST/EiJ	ENSTCUG00005039937	protein coding gene	Chr17:32508545-32531974 (-)
CBA/J	ENSMUSG00210051928	protein coding gene	Chr17:31193968-31217186 (-)
DBA/2J	ENSMUSG00185043362	protein coding gene	Chr17:34074202-34097179 (-)
FVB/NJ	ENSMUSG00205053310	protein coding gene	Chr17:31736117-31759143 (-)
JF1/MsJ	ENSUMUG00000017538	protein coding gene	Chr17:33015796-33038832 (-)
LP/J	ENSMUSG00230054481	protein coding gene	Chr17:35111246-35134494 (-)
NOD/ShiLtJ	ENSMUSG00190040877	protein coding gene	Chr17:31355273-31378296 (-)
NZO/HlLtJ	ENSMUSG00225051891	protein coding gene	Chr17:37187964-37211207 (-)
PWK/PhJ	ENSLUMG00010036889	protein coding gene	Chr17:30989909-31012900 (-)
SPRET/EiJ	ENSMSPG00010049391	protein coding gene	Chr17:32198700-32222118 (-)
WSB/EiJ	ENSIUOG00005051368	protein coding gene	Chr17:32177528-32200733 (-)

Human Ortholog

DDR1, discoidin domain receptor tyrosine kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDR1, discoidin domain receptor tyrosine kinase 1
Synonyms

CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE
Links

HGNC:2730

NCBI Gene ID: 780

UniProt: Q08345
Chr Location

6p21.33; chr6:30876421-30900978 (+) GRCh38

MGI Vertebrate Homology

Ddr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDR1
Gene Tree

Ddr1

Diseases

4 with human DDR1 associations

				Human Disease	Mouse Models
				breast carcinoma IDs breast carcinoma DOID:3459 EFO:0000305 MESH:D001943 NCI:C4872 UMLS_CUI:C0678222
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				osteosarcoma IDs osteosarcoma DOID:3347 DOID:183 MESH:D012516 MESH:D018213 NCI:C9145 OMIM:259500 ORDO:668 UMLS_CUI:C0029463 UMLS_CUI:C0206639
				skin melanoma IDs skin melanoma DOID:8923 DOID:0050609 DOID:10043 DOID:10046 DOID:10051 DOID:10052 DOID:10055 DOID:8922 ICD10CM:C43.9 ICD9CM:172 ICD9CM:172.0 ICD9CM:172.2 ICD9CM:172.4 ICD9CM:172.5 ICD9CM:172.9 MESH:D000096142 NCI:C3510 UMLS_CUI:C0151779

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 3 alleles in 5 genetic backgrounds
3 phenotypes from multigenic genotypes
1 images
51 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

7
Gene trapped

5
Targeted

8
Genomic Mutations

1 involving Ddr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice are viable but smaller than control mice. Most mutant females are not able to give birth because developing blastocysts fail to implant. Successfully reproducing females show a lactation defect which is attributed to hyperproliferation and aberrant branching of mammary ducts.

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All GO Annotations

65
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

74
cDNA Data

204
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddr1

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All Sequences

121
RefSeq

41
UniProt

12
CCDS

CCDS28703.1, CCDS37603.1

Ensembl

ENSMUSG00000003534 (Evidence)
NCBI Gene

12305

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003534	Ensembl Gene Model \| MGI Sequence Detail	23055	C57BL/6J	± kb
transcript	ENSMUST00000119825	Ensembl \| MGI Sequence Detail	3769	Not Applicable
polypeptide	ENSMUSP00000113062	Ensembl \| MGI Sequence Detail	911	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000001445 discoidin domain-containing receptor 1

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR000421 Coagulation factor 5/8, C-terminal domain

IPR048525 Discoidin domain-containing receptor 1/2, DS-like domain

IPR008979 Galactose-binding-like domain superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
GlyGen

Q03146 5 sites

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All nucleic 211

Genomic 3

cDNA 207

Other 1

Antibodies 3

Microarray probesets 6

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MGD-MRK-15973, MGD-MRK-28168, MGI:2146824

Summaries

All 123

Developmental Gene Expression 13

Gene Ontology 16

Phenotypes 51
Earliest

J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
Latest

J:379261 de-la-Puente-Ovejero L, et al., RAF1 as a standalone therapeutic target in KRAS-driven lung adenocarcinoma: No added efficacy from co-targeting ARAF, EGFR, or DDR1. PLoS One. 2026;21(2):e0341778

TSS for Ddr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147877	Chr17:36015466-36015524 (-)	18 bp
Tssr147876	Chr17:36014892-36014983 (-)	575 bp
Tssr147875	Chr17:36014863-36014886 (-)	638 bp
Tssr147874	Chr17:36013189-36013266 (-)	2,285 bp
Tssr147873	Chr17:36013108-36013120 (-)	2,399 bp
Tssr147872	Chr17:36012932-36012960 (-)	2,567 bp
Tssr147871	Chr17:36012914-36012929 (-)	2,591 bp
Tssr147870	Chr17:36012895-36012908 (-)	2,611 bp
Tssr147869	Chr17:36012829-36012838 (-)	2,679 bp
Tssr147866	Chr17:36008898-36008923 (-)	6,602 bp
Tssr147865	Chr17:36008872-36008893 (-)	6,630 bp
Tssr147864	Chr17:36008662-36008673 (-)	6,845 bp
Tssr147863	Chr17:36008594-36008642 (-)	6,895 bp
Tssr147862	Chr17:36001276-36001313 (-)	14,218 bp
Tssr147861	Chr17:35999881-35999923 (-)	15,611 bp
Tssr147860	Chr17:35996312-35996323 (-)	19,195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24