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Zfx Gene Detail
Summary
  • Symbol
    Zfx
  • Name
    zinc finger protein X-linked
  • Synonyms
    Zfx5, Zfx5,6, Zfx6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99211
    NCBI Gene: 22764
  • Gene Overview
    MyGene.info: ZFX
Location & Maps
more
  • Sequence Map
    ChrX:94074631-94123702 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      49072 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.48 cM, cytoband D
  • Mapping Data
    37 experiments
  • Sequence Tag
    DXMit6
Homology
more
  • Human Ortholog
    ZFX, zinc finger protein, X-linked
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFX, zinc finger protein, X-linked
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZNF926
  • Links
    NCBI Gene ID: 7543
    neXtProt AC: NX_P17010

  • Chr Location
    Xp21.3; chrX:24148934-24216255 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 8 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    78
  • Gene trapped
    75
  • Targeted
    3
Male mice hemizygous or female mice homozygous for one knock-out allele exhibit reduced size, viability, and gametes. Another knock-out allele generates mice that exhibit embryonic lethality associated with abnormal extraembryonic tissue and reduction in hematopoietic stem cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    229
  • Tissues
    146
  • cDNA Data
    79
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018032 VEGA Gene Model | MGI Sequence Detail 49072 C57BL/6J ±  kb
transcript OTTMUST00000043537 VEGA | MGI Sequence Detail 7002 Not Applicable  
polypeptide OTTMUSP00000019571 VEGA | MGI Sequence Detail 799 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    116 from dbSNP Build 142
  • RFLP
    6
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017656 zinc finger X-chromosomal protein
  • InterPro Domains
    IPR006794 Transcriptional activator, Zfx / Zfy domain
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 116
    Genomic 30
    cDNA 82
    Primer pair 1
    Other 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-15963, MGI:1096553, MGI:1096556
References
more
  • Summaries
    All 83
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:9551 Nagamine CM, et al., Chromosome mapping and expression of a putative testis-determining gene in mouse. Science. 1989 Jan 6;243(4887):80-3
  • Latest
    J:216695 Palmer CJ, et al., Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res. 2014 Oct 15;74(20):5914-24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory