Zfx MGI Mouse Gene Detail - MGI:99211 - zinc finger protein X-linked

Zfx Gene Detail

Symbol

Zfx
Name

zinc finger protein X-linked
Synonyms

Zfx5, Zfx5,6, Zfx6

Feature Type

protein coding gene
IDs

MGI:99211
NCBI Gene: 22764
Gene Overview

MyGene.info: ZFX

Sequence Map

ChrX:94074631-94123702 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

49072 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 41.48 cM, cytoband D
Mapping Data

37 experiments
Sequence Tag

DXMit6

Human Ortholog

ZFX, zinc finger protein, X-linked

Vertebrate Orthologs

10

Human Ortholog

ZFX, zinc finger protein, X-linked
Orthology source: HomoloGene, HGNC
Synonyms

ZNF926
Links

HGNC:12869

NCBI Gene ID: 7543

neXtProt AC: NX_P17010

UniProt: P17010
Chr Location

Xp22.11; chrX:24148994-24216255 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2561
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ZFX
Protein SuperFamily

zinc finger protein ZFP-36
Gene Tree

Zfx

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Phenotype Summary

26 phenotypes from 3 alleles in 8 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Gene trapped

75
Targeted

3
Find Mice (IMSR)

33 strains or lines available

Male mice hemizygous or female mice homozygous for one knock-out allele exhibit reduced size, viability, and gametes. Another knock-out allele generates mice that exhibit embryonic lethality associated with abnormal extraembryonic tissue and reduction in hematopoietic stem cells.

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All GO Annotations

22
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

229
Tissues

146
cDNA Data

79
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Zfx interacts with 433 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

68
RefSeq

20
UniProt

7
CCDS

CCDS30276.1
UniGene

919

			Length	Strain/Species	Flank
genomic	OTTMUSG00000018032	VEGA Gene Model \| MGI Sequence Detail	49072	C57BL/6J	± kb
transcript	OTTMUST00000043537	VEGA \| MGI Sequence Detail	7002	Not Applicable
polypeptide	OTTMUSP00000019571	VEGA \| MGI Sequence Detail	799	Not Applicable

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SNPs within 2kb

116 from dbSNP Build 142

RFLP

6

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UniProt

7 Sequences
Protein Ontology

PR:000017656 zinc finger X-chromosomal protein

(term hierarchy)
InterPro Domains

IPR006794 Transcriptional activator, Zfx / Zfy domain

IPR013087 Zinc finger C2H2-type

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All nucleic 116

Genomic 30

cDNA 82

Primer pair 1

Other 3

Microarray probesets 7

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MGD-MRK-15963, MGI:1096553, MGI:1096556

Summaries

All 83

Developmental Gene Expression 8

Gene Ontology 4

Phenotypes 13
Earliest

J:9551 Nagamine CM, et al., Chromosome mapping and expression of a putative testis-determining gene in mouse. Science. 1989 Jan 6;243(4887):80-3
Latest

J:216695 Palmer CJ, et al., Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res. 2014 Oct 15;74(20):5914-24

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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