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Zfp57 Gene Detail
Summary
  • Symbol
    Zfp57
  • Name
    zinc finger protein 57
  • Synonyms
    G19
  • Feature Type
    protein coding gene
  • IDs
    MGI:99204
    NCBI Gene: 22715
  • Gene Overview
    MyGene.info: ZFP57
Location & Maps
more
  • Sequence Map
    Chr17:37001163-37010635 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.16 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZFP57, ZFP57 zinc finger protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ZFP57, ZFP57 zinc finger protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA145L22, bA145L22.2, C6orf40, TNDM1, ZNF698
  • Links
    NCBI Gene ID: 346171
    neXtProt AC: NX_Q9NU63

  • Chr Location
    6p22.1; chr6:29672392-29681146 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ZFP57 associations

Human Disease Mouse Models
       Diabetes Mellitus, Transient Neonatal, 1   OMIM: 601410
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    74
  • Gene trapped
    69
  • Targeted
    5
  • Genomic Mutations
    1 involving Zfp57
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037387 VEGA Gene Model | MGI Sequence Detail 9473 C57BL/6J ±  kb
transcript OTTMUST00000096480 VEGA | MGI Sequence Detail 2597 Not Applicable  
polypeptide OTTMUSP00000053909 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 20
    Genomic 2
    cDNA 17
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15901, MGD-MRK-15956
References
more
  • Summaries
    All 47
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:17110 Okazaki S, et al., A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem. 1994 Mar 4;269(9):6900-7
  • Latest
    J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory