Zfp57
Gene Detail

Symbol Name ID

Zfp57 zinc finger protein 57 MGI:99204

Synonyms

G19

Feature Type

protein coding gene

Genetic Map

Chromosome 17

19.16 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:37001163-37010635 bp, + strand From VEGA annotation of GRCm38   9473 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Zfp57

Human homologs

Human Homolog		ZFP57, ZFP57 zinc finger protein
NCBI Gene ID		346171
neXtProt AC		NX_Q9NU63
Human Synonyms		bA145L22, bA145L22.2, C6orf40, TNDM1, ZNF698
Human Chr (Location)		6p22.1; chr6:29640169-29644931 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ZFP57

Alleles and phenotypes

All alleles(72) : Targeted(3) Gene trapped(69)
 

Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	DNA methylation involved in embryo development, multicellular organismal development, ...
Component	intracellular, nuclear heterochromatin, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (202)    Tissues (101)    Images (36)
Theiler Stages: 2, 3, 4, 5, 12, 14, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	130
Northern blot	21
RT-PCR	51

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(2) cDNA(17) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037387 (Evidence)
Ensembl Gene Model	ENSMUSG00000036036 (Evidence)
Entrez Gene	22715 (Evidence)
DFCI	TC1580183, TC1589837, TC1601582, TC1739979
DoTS	DT.101703539, DT.101722520, DT.101723238, DT.489181
NIA Mouse Gene Index	U017949
PDB	4GZN
Consensus CDS Project	CCDS28733.1, CCDS50106.1
International Mouse Knockout Project Status	Zfp57

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037387	VEGA Gene Model | MGI Sequence Detail	9473	C57BL/6J
transcript	OTTMUST00000096472	VEGA | MGI Sequence Detail	1749	Not Applicable
polypeptide	OTTMUSP00000053906	VEGA | MGI Sequence Detail	421	Not Applicable

All sequences(86) RefSeq(8) UniProt(7)

Polymorphisms

SNPs within 2kb(30 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001909	Krueppel-associated box
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017645	zinc finger protein 57

References

(Earliest) J:17110 Okazaki S, et al., A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem. 1994 Mar 4;269(9):6900-7
(Latest) J:180664 Zuo X, et al., Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem. 2012 Jan 13;287(3):2107-18
All references(45)

Other accession IDs

MGD-MRK-15901, MGD-MRK-15956