About   Help   FAQ
Zfp57
Gene Detail
Symbol

Name
ID
Zfp57
zinc finger protein 57
MGI:99204
Synonyms
G19
Feature Type
protein coding gene
Genetic Map
Chromosome 17
19.16 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:37001163-37010635 bp, + strand
From VEGA annotation of GRCm38

  9473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: ZFP57
Gene Tree: Zfp57

Human
homologs
ZFP57, ZFP57 zinc finger protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 346171
neXtProt AC: NX_Q9NU63

Human Synonyms: bA145L22, bA145L22.2, C6orf40, TNDM1, ZNF698

Human Chr (Location): 6p22.1; chr6:29672392-29681146 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ZFP57

Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(69) Targeted(5)
Genomic Mutations involving Zfp57 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.
 
Phenotype Images(1)
Interactions
Zfp57 interacts with 18 markers (Mir19a, Mir92-2, Mir152, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process DNA methylation involved in embryo development, multicellular organismal development, ...
Component intracellular, nuclear heterochromatin, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (195)    Tissues (98)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 130
Northern blot 21
RT-PCR 44
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037387 (Evidence)
Ensembl Gene Model ENSMUSG00000036036 (Evidence)
Entrez Gene 22715 (Evidence)
DFCI TC1580183, TC1589837, TC1601582, TC1739979
DoTS DT.101703539, DT.101722520, DT.101723238, DT.489181
NIA Mouse Gene Index U017949
PDB 4GZN, 4M9V
Consensus CDS Project CCDS28733.1, CCDS50106.1
International Mouse Phenotyping Consortium Status Zfp57
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037387 VEGA Gene Model | MGI Sequence Detail 9473 C57BL/6J ±  kb
transcript OTTMUST00000096480 VEGA | MGI Sequence Detail 2597 Not Applicable 
polypeptide OTTMUSP00000053909 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(34) UniProt(7)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001909 Krueppel-associated box
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017645 zinc finger protein 57 homolog
References
(Earliest) J:17110 Okazaki S, et al., A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem. 1994 Mar 4;269(9):6900-7
(Latest) J:220807 Shamis Y, et al., Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9
All references(49)
Other
accession IDs
MGD-MRK-15901, MGD-MRK-15956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory