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Zfp57
Gene Detail
 Symbol
Name
ID
Zfp57
zinc finger protein 57
MGI:99204
Synonyms G19
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.16 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:37001163-37010635 bp, + strand
From VEGA annotation of GRCm38

  9473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Zfp57

Human
homologs
Human Homolog ZFP57, ZFP57 zinc finger protein
NCBI Gene ID 346171
neXtProt AC  NX_Q9NU63
Human Synonyms  bA145L22, bA145L22.2, C6orf40, TNDM1, ZNF698
Human Chr (Location)  6p22.1; chr6:29672392-29681136 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZFP57
Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(69) Targeted(5)
Genomic Mutations involving Zfp57 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.
 
Interactions
Zfp57 interacts with 19 markers (Mir19a, Mir92-2, Mir152, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process DNA methylation involved in embryo development, multicellular organismal development, ...
Component intracellular, nuclear heterochromatin, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (202)    Tissues (101)    Images (36)
Theiler Stages: 2, 3, 4, 5, 12, 14, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 130
Northern blot 21
RT-PCR 51
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037387 (Evidence)
Ensembl Gene ModelENSMUSG00000036036 (Evidence)
Entrez Gene22715 (Evidence)
DFCITC1580183, TC1589837, TC1601582, TC1739979
DoTSDT.101703539, DT.101722520, DT.101723238, DT.489181
NIA Mouse Gene IndexU017949
PDB4GZN, 4M9V
Consensus CDS ProjectCCDS28733.1, CCDS50106.1
International Mouse Knockout Project StatusZfp57
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037387 VEGA Gene Model | MGI Sequence Detail 9473 C57BL/6J ±  kb
transcript OTTMUST00000096472 VEGA | MGI Sequence Detail 1749 Not Applicable 
polypeptide OTTMUSP00000053906 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(114) RefSeq(36) UniProt(7)
Polymorphisms SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001909 Krueppel-associated box
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017645 zinc finger protein 57 homolog
References (Earliest) J:17110 Okazaki S, et al., A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem. 1994 Mar 4;269(9):6900-7
(Latest) J:198387 Baglivo I, et al., Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1. FEBS Lett. 2013 May 21;587(10):1474-81
All references(49)
Other
accession IDs
MGD-MRK-15901, MGD-MRK-15956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory