Zfp57 MGI Mouse Gene Detail - MGI:99204

Symbol

Zfp57
Name

zinc finger protein 57
Synonyms

G19

Feature Type

protein coding gene
IDs

MGI:99204
NCBI Gene: 22715
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:37312055-37321527 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.16 cM, cytoband B3
Mapping Data

3 experiments

Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99204	protein coding gene	Chr17:37307060-37326196 (+)
129S1/SvImJ	ENSMUSG00200050281	protein coding gene	Chr17:32769049-32776016 (+)
A/J	ENSMUSG00195045601	protein coding gene	Chr17:33977794-33984763 (+)
AKR/J	ENSMUSG00220035510	protein coding gene	Chr17:32710422-32717362 (+)
BALB/cJ	ENSMUSG00180029150	protein coding gene	Chr17:33458613-33465580 (+)
C3H/HeJ	ENSMUSG00175038387	protein coding gene	Chr17:32650951-32657891 (+)
C57BL/6NJ	ENSMUSG00215051159	protein coding gene	Chr17:32612909-32619881 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021564	protein coding gene	Chr17:33997308-34007398 (+)
CAST/EiJ	ENSTCUG00005051195	protein coding gene	Chr17:33849172-33856132 (+)
CBA/J	ENSMUSG00210040982	protein coding gene	Chr17:32387182-32394122 (+)
DBA/2J	ENSMUSG00185042694	protein coding gene	Chr17:35439554-35446521 (+)
FVB/NJ	ENSMUSG00205023188	protein coding gene	Chr17:32972727-32979694 (+)
JF1/MsJ	ENSUMUG00000056808	protein coding gene	Chr17:34382679-34388922 (+)
LP/J	ENSMUSG00230054421	protein coding gene	Chr17:36563906-36570873 (+)
NOD/ShiLtJ	ENSMUSG00190035056	protein coding gene	Chr17:32653008-32659975 (+)
NZO/HlLtJ	ENSMUSG00225052173	protein coding gene	Chr17:38520018-38526934 (+)
PWK/PhJ	ENSLUMG00010031031	protein coding gene	Chr17:32265887-32272006 (+)
SPRET/EiJ	ENSMSPG00010036991	protein coding gene	Chr17:33520346-33528975 (+)
WSB/EiJ	ENSIUOG00005048685	protein coding gene	Chr17:33480413-33487338 (+)

Human Ortholog

ZFP57, ZFP57 zinc finger protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFP57, ZFP57 zinc finger protein
Synonyms

bA145L22, bA145L22.2, C6orf40, TNDM1, ZNF698
Links

HGNC:18791

NCBI Gene ID: 346171

UniProt: Q9NU63
Chr Location

6p22.1; chr6:29672392-29681155 (-) GRCh38

MGI Vertebrate Homology

Zfp57 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZFP57
Gene Tree

Zfp57

Diseases

1 with human ZFP57 associations

				Human Disease	Mouse Models
				transient neonatal diabetes mellitus 1 IDs transient neonatal diabetes mellitus 1 DOID:0061173 OMIM:601410

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

70
Endonuclease-mediated

2
Gene trapped

61
Targeted

7
Genomic Mutations

1 involving Zfp57
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a knock-out allele exhibit some postnatal lethality with abnormal imprinting and fetal lethality observed in the homozygous offspring of homozygous females.

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All GO Annotations

24
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

831
Tissues

119
cDNA Data

15
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

77
RefSeq

13
UniProt

7
CCDS

CCDS28733.1, CCDS50106.1

Ensembl

ENSMUSG00000036036 (Evidence)
NCBI Gene

22715

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036036	Ensembl Gene Model \| MGI Sequence Detail	9473	C57BL/6J	± kb
transcript	ENSMUST00000174524	Ensembl \| MGI Sequence Detail	1747	Not Applicable
polypeptide	ENSMUSP00000134418	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017645 zinc finger protein 57 homolog

(term hierarchy)
PDB

4GZN, 4M9V
InterPro Domains

IPR001909 Krueppel-associated box

IPR036051 Krueppel-associated box domain superfamily

IPR050169 Krueppel C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q8C6P8 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

Genomic 2

cDNA 20

Primer pair 1

Antibodies 1

Microarray probesets 3

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MGD-MRK-15901, MGD-MRK-15956

Summaries

All 68

Developmental Gene Expression 16

Gene Ontology 11

Phenotypes 21
Earliest

J:17110 Okazaki S, et al., A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem. 1994 Mar 4;269(9):6900-7
Latest

J:383243 Hisamatsu D, et al., Identification of a set of transcriptional regulators involved in the temporal regulation of neuronal subtype differentiation. Dev Biol. 2026 Apr 16;535:66-84

TSS for Zfp57:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144534	Chr17:37313379-37313391 (+)	1,330 bp
Tssr144535	Chr17:37313402-37313416 (+)	1,354 bp
Tssr144536	Chr17:37313419-37313461 (+)	1,385 bp
Tssr144537	Chr17:37313466-37313478 (+)	1,417 bp
Tssr144538	Chr17:37313502-37313509 (+)	1,451 bp
Tssr144539	Chr17:37314575-37314578 (+)	2,522 bp
Tssr144540	Chr17:37320777-37320792 (+)	8,730 bp
Tssr144541	Chr17:37320859-37320860 (+)	8,805 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24