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Zfp42
Gene Detail
Symbol

Name
ID
Zfp42
zinc finger protein 42
MGI:99187
Synonyms
Rex1, Rex-1, Zfp-42
Feature Type
protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:43295068-43307009 bp, - strand
From Ensembl annotation of GRCm38

  11942 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7601  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ZFP42
Protein SuperFamily: zinc finger transcription factor Rex-1
Gene Tree: Zfp42

Human
homologs
ZFP42, ZFP42 zinc finger protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 132625
neXtProt AC: NX_Q96MM3

Human Synonyms: REX1, REX-1, zfp-42, ZNF754

Human Chr (Location): 4q35.2; chr4:187994054-188005050 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(97) : Gene trapped(92) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one knock-out allele exhibit premature age-related male germ cell loss, abnormal sperm morphology, and mild testicular atrophy.
 
Interactions
Zfp42 interacts with 68 markers (Mir18b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process in utero embryonic development, regulation of genetic imprinting, ...
Component cytoplasm, nucleus, ...
Function DNA binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (72)    Tissues (36)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
Northern blot 7
RT-PCR 39
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(3) cDNA(33) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000051176 (Evidence)
Entrez Gene 22702 (Evidence)
UniGene 285848
DFCI TC1582488, TC1590874, TC1635859
DoTS DT.532189, DT.94153091
NIA Mouse Gene Index U029767
Consensus CDS Project CCDS22267.1
International Mouse Phenotyping Consortium Status Zfp42
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051176 Ensembl Gene Model | MGI Sequence Detail 11942 C57BL/6J ±  kb
transcript ENSMUST00000082120 Ensembl | MGI Sequence Detail 1800 Not Applicable 
polypeptide ENSMUSP00000080765 Ensembl | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017644 zinc finger protein 42
References
(Earliest) J:10124 Hosler BA, et al., Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol. 1989 Dec;9(12):5623-9
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(61)
Other
accession IDs
MGD-MRK-13848, MGD-MRK-13849, MGD-MRK-15884, MGD-MRK-15939

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory