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Zfp42
Gene Detail
 Symbol
Name
ID
Zfp42
zinc finger protein 42
MGI:99187
Synonyms Rex1, Rex-1, Zfp-42
Feature Type protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:43295068-43307009 bp, - strand
From Ensembl annotation of GRCm38

  11942 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7601  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: zinc finger transcription factor Rex-1
Gene Tree: Zfp42

Human
homologs
Human Homolog ZFP42, ZFP42 zinc finger protein
NCBI Gene ID 132625
neXtProt AC  NX_Q96MM3
Human Synonyms  REX1, ZNF754
Human Chr (Location)  4q35.2; chr4:187995771-188005045 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(97) : Gene trapped(92) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit premature age-related male germ cell loss, abnormal sperm morphology, and mild testicular atrophy.
 
Interactions
Zfp42 interacts with 68 markers (Mir18b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process in utero embryonic development, regulation of genetic imprinting, ...
Component cytoplasm, nucleus, ...
Function DNA binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (72)    Tissues (36)    Images (4)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 11, 13, 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 26
Northern blot 7
RT-PCR 39
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(3) cDNA(33) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000051176 (Evidence)
Entrez Gene22702 (Evidence)
UniGene285848
DFCITC1582488, TC1590874, TC1635859
DoTSDT.532189, DT.94153091
NIA Mouse Gene IndexU029767
Consensus CDS ProjectCCDS22267.1
International Mouse Knockout Project StatusZfp42
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051176 Ensembl Gene Model | MGI Sequence Detail 11942 C57BL/6J ±  kb
transcript ENSMUST00000082120 Ensembl | MGI Sequence Detail 1800 Not Applicable 
polypeptide ENSMUSP00000080765 Ensembl | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017644 zinc finger protein 42
References (Earliest) J:10124 Hosler BA, et al., Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol. 1989 Dec;9(12):5623-9
(Latest) J:203737 Oda M, et al., Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One. 2013;8(6):e68846
All references(60)
Other
accession IDs
MGD-MRK-13848, MGD-MRK-13849, MGD-MRK-15884, MGD-MRK-15939

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory