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Pcgf2 Gene Detail
Summary
  • Symbol
    Pcgf2
  • Name
    polycomb group ring finger 2
  • Synonyms
    mel-18, Mel18, Rnf110, Zfp144
  • Feature Type
    protein coding gene
  • IDs
    MGI:99161
    NCBI Gene: 22658
  • Gene Overview
    MyGene.info: PCGF2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97688823-97700497 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.06 cM, cytoband C1-C3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99161
protein coding gene Chr11:97688821-97701348 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019036
protein coding gene Chr11:100145393-100158803 (-)
A/J MGP_AJ_G0019004
protein coding gene Chr11:96010881-96023717 (-)
AKR/J MGP_AKRJ_G0018974
protein coding gene Chr11:98997434-99007587 (-)
BALB/cJ MGP_BALBcJ_G0018977
protein coding gene Chr11:96511873-96523999 (-)
C3H/HeJ MGP_C3HHeJ_G0018791
protein coding gene Chr11:99111311-99123990 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019430
protein coding gene Chr11:103236613-103246207 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017061
protein coding gene Chr11:93465991-93476500 (-)
CAST/EiJ MGP_CASTEiJ_G0018345
protein coding gene Chr11:99979038-99990225 (-)
CBA/J MGP_CBAJ_G0018762
protein coding gene Chr11:107500983-107512430 (-)
DBA/2J MGP_DBA2J_G0018870
protein coding gene Chr11:95562882-95574422 (-)
FVB/NJ MGP_FVBNJ_G0018859
protein coding gene Chr11:95056477-95069556 (-)
LP/J MGP_LPJ_G0018940
protein coding gene Chr11:100651917-100665620 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018886
protein coding gene Chr11:107338411-107352377 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019470
protein coding gene Chr11:99293889-99309537 (-)
PWK/PhJ MGP_PWKPhJ_G0018117
protein coding gene Chr11:96548095-96560809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017907
protein coding gene Chr11:99012260-99022811 (-)
WSB/EiJ MGP_WSBEiJ_G0018395
protein coding gene Chr11:99202657-99215942 (-)



Homology
more
  • Human Ortholog
    PCGF2, polycomb group ring finger 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PCGF2, polycomb group ring finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEL-18, RNF110, TPFS, ZNF144
  • Links
    NCBI Gene ID: 7703
    neXtProt AC: NX_P35227
    UniProt: P35227

  • Chr Location
    17q12; chr17:38733897-38749817 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5174
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PCGF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 5 genetic backgrounds
    44 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit multiple abnormalities of the axial skeleton (including homeotic transformations), grow markedly slower, and die either perinatally or between 3-6 weeks of age depending on genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018537 Ensembl Gene Model | MGI Sequence Detail 11675 C57BL/6J ±  kb
    transcript ENSMUST00000179765 Ensembl | MGI Sequence Detail 2485 Not Applicable  
    polypeptide ENSMUSP00000137517 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 5
      cDNA 44

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15913
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 36
    • Earliest
      J:37393 Croyle ML, et al., Analysis of the organization and nucleotide sequence of the chromosomal gene for the beta-subunit of rat thyrotropin. DNA. 1986 Aug;5(4):299-304
    • Latest
      J:262366 Liu X, et al., BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017 Dec;153(6):1607-1620

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/17/2019
    MGI 6.14
    The Jackson Laboratory