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Yes1 Gene Detail
Summary
  • Symbol
    Yes1
  • Name
    YES proto-oncogene 1, Src family tyrosine kinase
  • Synonyms
    Yes
  • Feature Type
    protein coding gene
  • IDs
    MGI:99147
    NCBI Gene: 22612
  • Gene Overview
    MyGene.info: YES1
Location & Maps
more
  • Sequence Map
    Chr5:32611171-32687057 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75887 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.33 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    YES1, YES proto-oncogene 1, Src family tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YES1, YES proto-oncogene 1, Src family tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    c-yes, HsT441, P61-YES, Yes
  • Links
    NCBI Gene ID: 7525
    neXtProt AC: NX_P07947

  • Chr Location
    18p11.31-p11.21; chr18:721588-812326 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    42 phenotype references
  • All Mutations and Alleles
    168
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    158
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    7 involving Yes1
  • Incidental Mutations
Homozygotes for targeted null alleles have no overt phenotype, but mice homozygous for both Yes and Src null mutations exhibit impaired movement and breathing, resulting in perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055350 VEGA Gene Model | MGI Sequence Detail 75887 C57BL/6J ±  kb
transcript OTTMUST00000137034 VEGA | MGI Sequence Detail 2657 Not Applicable  
polypeptide OTTMUSP00000072225 VEGA | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    312 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    cDNA 16
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15844, MGI:2140834
References
more
  • Summaries
    All 75
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 9
    Phenotypes 42
  • Earliest
    J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
  • Latest
    J:223120 Bi Y, et al., Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C622-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory