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Yes1 Gene Detail
Summary
  • Symbol
    Yes1
  • Name
    YES proto-oncogene 1, Src family tyrosine kinase
  • Synonyms
    Yes
  • Feature Type
    protein coding gene
  • IDs
    MGI:99147
    NCBI Gene: 22612
  • Gene Overview
    MyGene.info: YES1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:32611171-32687057 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.33 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99147
protein coding gene Chr5:32611171-32687066 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029436
protein coding gene Chr5:30705163-30776619 (+)
A/J MGP_AJ_G0029402
protein coding gene Chr5:29684641-29753288 (+)
AKR/J MGP_AKRJ_G0029352
protein coding gene Chr5:30862545-30932189 (+)
BALB/cJ MGP_BALBcJ_G0029413
protein coding gene Chr5:30220710-30301521 (+)
C3H/HeJ MGP_C3HHeJ_G0029134
protein coding gene Chr5:30877335-30952721 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029866
protein coding gene Chr5:32513696-32578908 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027104
protein coding gene Chr5:27348013-27410840 (+)
CAST/EiJ MGP_CASTEiJ_G0028544
protein coding gene Chr5:29978943-30047008 (+)
CBA/J MGP_CBAJ_G0029102
protein coding gene Chr5:33217492-33302503 (+)
DBA/2J MGP_DBA2J_G0029251
protein coding gene Chr5:29863151-29937258 (+)
FVB/NJ MGP_FVBNJ_G0029209
protein coding gene Chr5:29282141-29360883 (+)
LP/J MGP_LPJ_G0029336
protein coding gene Chr5:31144917-31226276 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029238
protein coding gene Chr5:34006008-34087897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029900
protein coding gene Chr5:30363819-30441043 (+)
PWK/PhJ MGP_PWKPhJ_G0028269
protein coding gene Chr5:29029582-29095708 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028100
protein coding gene Chr5:29844083-29918994 (+)
WSB/EiJ MGP_WSBEiJ_G0028625
protein coding gene Chr5:30466698-30538979 (+)



Homology
more
  • Human Ortholog
    YES1, YES proto-oncogene 1, Src family tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YES1, YES proto-oncogene 1, Src family tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-yes, HsT441, P61-YES, Yes
  • Links
    NCBI Gene ID: 7525
    neXtProt AC: NX_P07947
    UniProt: P07947

  • Chr Location
    18p11.32; chr18:721592-812326 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    44 phenotype references
Homozygotes for targeted null alleles have no overt phenotype, but mice homozygous for both Yes and Src null mutations exhibit impaired movement and breathing, resulting in perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014932 Ensembl Gene Model | MGI Sequence Detail 75887 C57BL/6J ±  kb
transcript ENSMUST00000168707 Ensembl | MGI Sequence Detail 2259 Not Applicable  
polypeptide ENSMUSP00000132161 Ensembl | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15844, MGI:2140834
References
more
  • Summaries
    All 103
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 9
    Phenotypes 44
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:236752 Sprowl JA, et al., A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16;7:10880

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory