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Ybx1
Gene Detail
Symbol

Name
ID
Ybx1
Y box protein 1
MGI:99146
Synonyms
dbpB, DNA binding protein B, EF1A, MSY1, Nsep1, YB-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
55.34 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:119277981-119294604 bp, - strand
From VEGA annotation of GRCm38

  16624 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Y box-binding protein 1
Gene Tree: Ybx1

Human
homologs
Human Homolog YBX1, Y box binding protein 1
NCBI Gene ID 4904
neXtProt AC  NX_P67809
Human Synonyms  BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP1, NSEP-1, YB1, YB-1
Human Chr (Location)  1p34; chr1:42682389-42702353 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence.
 
Phenotype Images(2)
Interactions
Ybx1 interacts with 149 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process CRD-mediated mRNA stabilization, in utero embryonic development, ...
Component CRD-mediated mRNA stability complex, cytoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (120)    Tissues (65)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
Northern blot 8
Western blot 25
RT-PCR 37
cDNA source data(513)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(524) cDNA(515) Primer pair(7) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000009259 (Evidence)
Ensembl Gene ModelENSMUSG00000028639 (Evidence)
Entrez Gene22608 (Evidence)
UniGene258204
DFCITC1573955, TC1599619, TC1650861, TC1753325
Consensus CDS ProjectCCDS18579.1
International Mouse Knockout Project StatusYbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009259 VEGA Gene Model | MGI Sequence Detail 16624 C57BL/6J ±  kb
transcript OTTMUST00000020973 VEGA | MGI Sequence Detail 1628 Not Applicable 
polypeptide OTTMUSP00000009615 VEGA | MGI Sequence Detail 322 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(6) UniProt(15)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019844 Cold-shock conserved site
InterPro IPR011129 Cold shock protein
InterPro IPR002059 Cold-shock protein, DNA-binding
InterPro IPR012340 Nucleic acid-binding, OB-fold
Protein Ontology PR:000017525 nuclease-sensitive element-binding protein 1
References
(Earliest) J:1387 Shaughnessy M, et al., Absence of MHC gene expression in lens and cloning of dbpB/YB-1, a DNA-binding protein expressed in mouse lens. Curr Eye Res. 1992 Feb;11(2):175-81
(Latest) J:211289 Fantauzzo KA, et al., PI3K-mediated PDGFRalpha signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev. 2014 May 1;28(9):1005-17
All references(72)
Other
accession IDs
MGD-MRK-15843, MGI:2140677

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory