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Ybx1 Gene Detail
Summary
  • Symbol
    Ybx1
  • Name
    Y box protein 1
  • Synonyms
    dbpB, DNA binding protein B, EF1A, MSY1, Nsep1, YB-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99146
    NCBI Gene: 22608
  • Gene Overview
    MyGene.info: YBX1
Location & Maps
more
  • Sequence Map
    Chr4:119277981-119294604 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16624 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    YBX1, Y-box binding protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    YBX1, Y-box binding protein 1
    Orthology source: HomoloGene
  • Synonyms
    BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP1, NSEP-1, YB1, YB-1
  • Links
    NCBI Gene ID: 4904
    neXtProt AC: NX_P67809

  • Chr Location
    1p34; chr1:42682389-42702363 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Gene trapped
    14
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Ybx1
  • Incidental Mutations
Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009259 VEGA Gene Model | MGI Sequence Detail 16624 C57BL/6J ±  kb
transcript OTTMUST00000020973 VEGA | MGI Sequence Detail 1628 Not Applicable  
polypeptide OTTMUSP00000009615 VEGA | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000017525 nuclease-sensitive element-binding protein 1
  • InterPro Domains
    IPR019844 Cold-shock conserved site
    IPR011129 Cold shock protein
    IPR002059 Cold-shock protein, DNA-binding
    IPR012340 Nucleic acid-binding, OB-fold
Molecular
Reagents
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  • All nucleic 524
    cDNA 515
    Primer pair 7
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-15843, MGI:2140677
References
more
  • Summaries
    All 75
    Developmental Gene Expression 13
    Gene Ontology 12
    Phenotypes 18
  • Earliest
    J:1387 Shaughnessy M, et al., Absence of MHC gene expression in lens and cloning of dbpB/YB-1, a DNA-binding protein expressed in mouse lens. Curr Eye Res. 1992 Feb;11(2):175-81
  • Latest
    J:218987 Lyabin DN, et al., Alternative forms of Y-box binding protein 1 and YB-1 mRNA. PLoS One. 2014;9(8):e104513

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory