Ybx1
Gene Detail

Symbol Name ID

Ybx1 Y box protein 1 MGI:99146

Synonyms

dbpB, DNA binding protein B, EF1A, MSY1, Nsep1, YB-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

55.34 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:119277981-119294604 bp, - strand From VEGA annotation of GRCm38   16624 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:88707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Y box-binding protein 1
Gene Tree: Ybx1

Human homologs

Human Homolog		YBX1, Y box binding protein 1
NCBI Gene ID		4904
neXtProt AC		NX_P67809
Human Synonyms		BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP1, NSEP-1, YB1, YB-1
Human Chr (Location)		1p34; chr1:43148066-43168020 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(4) Gene trapped(14)
 

Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	CRD-mediated mRNA stabilization, in utero embryonic development, ...
Component	CRD-mediated mRNA stability complex, cytoplasm, ...
Function	DNA binding, mRNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (134)    Tissues (66)    Images (10)
Theiler Stages: 1, 2, 3, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	50
Northern blot	10
Western blot	25
RT-PCR	49

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(24) Primer pair(7) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000009259 (Evidence)
Ensembl Gene Model	ENSMUSG00000028639 (Evidence)
Entrez Gene	22608 (Evidence)
DFCI	TC1573955, TC1599619, TC1650861, TC1753325
Consensus CDS Project	CCDS18579.1
International Mouse Knockout Project Status	Ybx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009259	VEGA Gene Model | MGI Sequence Detail	16624	C57BL/6J
transcript	OTTMUST00000020973	VEGA | MGI Sequence Detail	1628	Not Applicable
polypeptide	OTTMUSP00000009615	VEGA | MGI Sequence Detail	322	Not Applicable

All sequences(82) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019844	Cold-shock conserved site
InterPro	IPR011129	Cold shock protein
InterPro	IPR002059	Cold-shock protein, DNA-binding
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
Protein Ontology	PR:000017525	nuclease-sensitive element-binding protein 1

References

(Earliest) J:1387 Shaughnessy M, et al., Absence of MHC gene expression in lens and cloning of dbpB/YB-1, a DNA-binding protein expressed in mouse lens. Curr Eye Res. 1992 Feb;11(2):175-81
(Latest) J:178467 Ohashi S, et al., Translational level of acetylcholine receptor alpha mRNA in mouse skeletal muscle is regulated by YB-1 in response to neural activity. Biochem Biophys Res Commun. 2011 Nov 4;414(4):647-52
All references(68)

Other accession IDs

MGD-MRK-15843, MGI:2140677