Yaa
Cytogenetic Marker Detail

Symbol Name ID

Yaa accelerated autoimmunity and lymphoproliferation transposition MGI:99140

Synonyms

Tp(X;Y)1Ekw

Feature Type

chromosomal translocation

Genetic Map

Chromosome Y
Syntenic

Mapping data(1)

Alleles and phenotypes

All alleles(1) : Spontaneous(1)
 

Mutant males have accelerated autoimmunity, lymphoproliferation, splenomegaly, hemolytic anemia, hypergammaglobulinemia and glomerulonephritis. The syndrome is strain-dependent, requiring presence of certain autosomal allelic combinations.

 
Human Diseases Modeled Using Mouse Yaa (1)    Alleles Annotated to Human Diseases(1)   

Other database links

Entrez Gene

107944

References

(Earliest) J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
(Latest) J:190844 Baccala R, et al., Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. J Immunol. 2012 Dec 15;189(12):5976-84
All references(80)

Other accession IDs

MGD-MRK-15837