Yaa
Cytogenetic Marker Detail

Symbol

Name
ID

Yaa
accelerated autoimmunity and lymphoproliferation transposition
MGI:99140

Synonyms

Tp(X;Y)1Ekw

Feature Type

chromosomal translocation

Genetic Map

Chromosome Y
Syntenic

Mapping data(1)

Mutations,
alleles, and
phenotypes

All mutations/alleles(1) : Spontaneous(1)
 

Mutant males have accelerated autoimmunity, lymphoproliferation, splenomegaly, hemolytic anemia, hypergammaglobulinemia and glomerulonephritis. The syndrome is strain-dependent, requiring presence of certain autosomal allelic combinations.

 
Human Diseases Modeled in Mice Using Yaa (1)    Mutations Annotated to Human Diseases (1)   

Other database
links

Entrez Gene

107944

References

(Earliest) J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
(Latest) J:206236 McPhee CG, et al., IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol. 2013 Nov 1;191(9):4581-8
All references(82)
Disease annotation references (6)

Other
accession IDs

MGD-MRK-15837