About   Help   FAQ
Yaa Cytogenetic Marker Detail
Summary
  • Symbol
    Yaa
  • Name
    accelerated autoimmunity and lymphoproliferation transposition
  • Synonyms
    Tp(X;Y)1Ekw
  • Feature Type
    chromosomal translocation
  • IDs
    MGI:99140
    NCBI Gene: 107944
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome Y, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
more
  • Diseases
    1 with Yaa mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 10 genetic backgrounds
    37 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Spontaneous
    1
Mutant males have accelerated autoimmunity, lymphoproliferation, splenomegaly, hemolytic anemia, hypergammaglobulinemia and glomerulonephritis. The syndrome is strain-dependent, requiring presence of certain autosomal allelic combinations.
Gene Ontology
(GO)
Classifications
less
Sequences &
Gene Models
less
Other
Accession IDs
less
MGD-MRK-15837
References
more
  • Summaries
    All 83
    Diseases 8
    Phenotypes 67
  • Earliest
    J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
  • Latest
    J:231621 Anderson LA, et al., Mind the Gap: Two Dissociable Mechanisms of Temporal Processing in the Auditory System. J Neurosci. 2016 Feb 10;36(6):1977-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory