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Yaa
Cytogenetic Marker Detail
 Symbol
Name
ID
Yaa
accelerated autoimmunity and lymphoproliferation transposition
MGI:99140
Synonyms Tp(X;Y)1Ekw
Feature Type chromosomal translocation
Genetic Map
Chromosome Y
Syntenic

Mapping data(1)
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
 
Mutant males have accelerated autoimmunity, lymphoproliferation, splenomegaly, hemolytic anemia, hypergammaglobulinemia and glomerulonephritis. The syndrome is strain-dependent, requiring presence of certain autosomal allelic combinations.
 
Human Diseases Modeled Using Mouse Yaa (1)    Alleles Annotated to Human Diseases(1)   
Other database
links
Entrez Gene107944
References (Earliest) J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
(Latest) J:206236 McPhee CG, et al., IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol. 2013 Nov 1;191(9):4581-8
All references(82)
Disease annotation references (6)
Other
accession IDs
MGD-MRK-15837

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory