Wnt7b MGI Mouse Gene Detail - MGI:98962 - wingless-type MMTV integration site family, member 7B

Wnt7b Gene Detail

Symbol

Wnt7b
Name

wingless-type MMTV integration site family, member 7B
Synonyms

Wnt-7b

Feature Type

protein coding gene
IDs

MGI:98962
NCBI Gene: 22422
Gene Overview

MyGene.info: WNT7B
Alliance

gene page

Sequence Map

Chr15:85535439-85581821 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

46383 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.39 cM
Mapping Data

4 experiments

Human Ortholog

WNT7B, Wnt family member 7B

Vertebrate Orthologs

8

Human Ortholog

WNT7B, Wnt family member 7B
Orthology source: HomoloGene, HGNC
Links

HGNC:12787

NCBI Gene ID: 7477

neXtProt AC: NX_P56706

UniProt: P56706
Chr Location

22q13.31; chr22:45920362-45977128 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22531
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: WNT7B
Protein SuperFamily

int-1 transforming protein
Gene Tree

Wnt7b

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References

1 with disease annotations

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Phenotype Summary

39 phenotypes from 5 alleles in 6 genetic backgrounds
24 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

1
Radiation induced

2
Targeted

9
Genomic Mutations

3 involving Wnt7b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

10 strains or lines available

Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.

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All GO Annotations

72
GO References

22

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1022
Tissues

549
cDNA Data

62
Literature Summary

198

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WNT7B

Xenbase wnt7b

ZFIN wnt7ba, wnt7bb

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Wnt7b interacts with 193 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

27
RefSeq

6
UniProt

4
CCDS

CCDS37171.1, CCDS49691.1, CCDS49692.1
UniGene

306946

Ensembl

ENSMUSG00000022382 (Evidence)
NCBI Gene

22422

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022382	Ensembl Gene Model \| MGI Sequence Detail	46383	C57BL/6J	± kb
transcript	ENSMUST00000109424	Ensembl \| MGI Sequence Detail	3492	Not Applicable
polypeptide	ENSMUSP00000105051	Ensembl \| MGI Sequence Detail	353	Not Applicable

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SNPs within 2kb

186 from dbSNP Build 142

PCR

1
RFLP

1

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UniProt

4 Sequences
InterPro Domains

IPR005817 Wnt

IPR013300 Wnt-7 protein

IPR018161 Wnt protein, conserved site

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All nucleic 91

cDNA 68

Primer pair 13

Other 10

Microarray probesets 5

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MGD-MRK-15447, MGD-MRK-15457

Summaries

All 279

Developmental Gene Expression 198

Diseases 1

Gene Ontology 22

Phenotypes 44
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:256044 Cho C, et al., Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017 Aug 30;95(5):1056-1073.e5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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