Wnt7b
Gene Detail

Symbol Name ID

Wnt7b wingless-related MMTV integration site 7B MGI:98962

Synonyms

Wnt-7b

Feature Type

protein coding gene

Genetic Map

Chromosome 15

40.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:85535439-85581821 bp, - strand From Ensembl annotation of GRCm38   46383 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt7b

Human homologs

Human Homolog		WNT7B, wingless-type MMTV integration site family, member 7B
NCBI Gene ID		7477
neXtProt AC		NX_P56706
Human Chr (Location)		22q13; chr22:46316246-46373008 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(8) Gene trapped(1)
 

Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.

 

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	activation of JUN kinase activity, anatomical structure regression, ...
Component	cell surface, cytoplasm, ...
Function	frizzled binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (150 records)
Data Summary: Results (793)    Tissues (391)    Images (164)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	690
Northern blot	21
Western blot	1
RT-PCR	74
RNase protection	2

cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) cDNA(64) Primer pair(13) Other(8)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022382 (Evidence)
Entrez Gene	22422 (Evidence)
UniGene	306946
DFCI	TC1580998, TC1597352, TC1602291
DoTS	DT.101725892, DT.530872, DT.97386548
NIA Mouse Gene Index	U036500
Consensus CDS Project	CCDS37171.1, CCDS49691.1, CCDS49692.1
International Mouse Knockout Project Status	Wnt7b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022382	Ensembl Gene Model | MGI Sequence Detail	46383	C57BL/6J
transcript	ENSMUST00000109424	Ensembl | MGI Sequence Detail	3492	Not Applicable
polypeptide	ENSMUSP00000105051	Ensembl | MGI Sequence Detail	353	Not Applicable

All sequences(34) RefSeq(6) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(175 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013300	Wnt-7 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017449	protein Wnt-7b

References

(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:195145 Amaniti EM, et al., Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum. Dev Biol. 2013 Apr 15;376(2):113-24
All references(207)

Other accession IDs

MGD-MRK-15447, MGD-MRK-15457