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Wnt7b Gene Detail
Summary
  • Symbol
    Wnt7b
  • Name
    wingless-type MMTV integration site family, member 7B
  • Synonyms
    Wnt-7b
  • Feature Type
    protein coding gene
  • IDs
    MGI:98962
    NCBI Gene: 22422
  • Gene Overview
    MyGene.info: WNT7B
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:85535437-85581821 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.39 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98962
 protein coding gene Chr15:85535437-85582473 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022193
 protein coding gene Chr15:86417022-86465047 (-)
A/J MGP_AJ_G0022152
 protein coding gene Chr15:83199141-83246856 (-)
AKR/J MGP_AKRJ_G0022127
 protein coding gene Chr15:85657550-85707396 (-)
BALB/cJ MGP_BALBcJ_G0022158
 protein coding gene Chr15:83324933-83371146 (-)
C3H/HeJ MGP_C3HHeJ_G0021928
 protein coding gene Chr15:85595080-85644269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022603
 protein coding gene Chr15:89652422-89704261 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020128
 protein coding gene Chr15:79525819-79572341 (-)
CAST/EiJ MGP_CASTEiJ_G0021450
 protein coding gene Chr15:86400147-86446495 (-)
CBA/J MGP_CBAJ_G0021895
 protein coding gene Chr15:92636140-92682221 (-)
DBA/2J MGP_DBA2J_G0022022
 protein coding gene Chr15:82661269-82707897 (-)
FVB/NJ MGP_FVBNJ_G0022001
 protein coding gene Chr15:81732387-81780870 (-)
LP/J MGP_LPJ_G0022093
 protein coding gene Chr15:86582700-86630547 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022021
 protein coding gene Chr15:97331454-97381879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022618
 protein coding gene Chr15:85654153-85700341 (-)
PWK/PhJ MGP_PWKPhJ_G0021191
 protein coding gene Chr15:82671339-82718476 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021025
 protein coding gene Chr15:85356034-85403930 (-)
WSB/EiJ MGP_WSBEiJ_G0021499
 protein coding gene Chr15:86151827-86200730 (-)



Homology
more
  • Human Ortholog
    WNT7B, Wnt family member 7B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WNT7B, Wnt family member 7B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 7477
    neXtProt AC: NX_P56706
    UniProt: P56706

  • Chr Location
    22q13.31; chr22:45920362-45977128 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    25 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1668
  • Tissues
    562
  • cDNA Data
    63
  • Literature Summary
    228
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22422 NCBI Gene Model | MGI Sequence Detail 46385 C57BL/6J ±  kb
    transcript NM_001163634 RefSeq | MGI Sequence Detail 3510 C57BL/6  
    polypeptide P28047 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 69
      Primer pair 15
      Other 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15447, MGD-MRK-15457
    References
    more
    • Summaries
      All 320
      Developmental Gene Expression 228
      Diseases 1
      Gene Ontology 22
      Phenotypes 50
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:294228 Kalailingam P, et al., Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. J Clin Invest. 2020 Aug 3;130(8):4081-4093
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/10/2020
    MGI 6.16     		The Jackson Laboratory