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Wnt7b Gene Detail
Summary
  • Symbol
    Wnt7b
  • Name
    wingless-type MMTV integration site family, member 7B
  • Synonyms
    Wnt-7b
  • Feature Type
    protein coding gene
  • IDs
    MGI:98962
    NCBI Gene: 22422
  • Gene Overview
    MyGene.info: WNT7B
Location & Maps
more
  • Sequence Map
    Chr15:85535439-85581821 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      46383 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 40.39 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    WNT7B, Wnt family member 7B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WNT7B, Wnt family member 7B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 7477
    neXtProt AC: NX_P56706
    UniProt: P56706

  • Chr Location
    22q13.31; chr22:45920362-45977128 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    24 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    70
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1020
  • Tissues
    548
  • cDNA Data
    61
  • Literature Summary
    189
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022382 Ensembl Gene Model | MGI Sequence Detail 46383 C57BL/6J ±  kb
transcript ENSMUST00000109424 Ensembl | MGI Sequence Detail 3492 Not Applicable  
polypeptide ENSMUSP00000105051 Ensembl | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    186 from dbSNP Build 142
  • PCR
    1
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 90
    cDNA 67
    Primer pair 13
    Other 10

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-15447, MGD-MRK-15457
References
more
  • Summaries
    All 262
    Developmental Gene Expression 189
    Diseases 1
    Gene Ontology 21
    Phenotypes 42
  • Earliest
    J:13437 Bangham JW, Hairy ears, Eh. Mouse News Lett. 1965;33:68
  • Latest
    J:239523 Chen CM, et al., Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/16/2017
MGI 6.09 		The Jackson Laboratory