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Wnt7b
Gene Detail
 Symbol
Name
ID
Wnt7b
wingless-type MMTV integration site family, member 7B
MGI:98962
Synonyms Wnt-7b
Feature Type protein coding gene
Genetic Map
Chromosome 15
40.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:85535439-85581821 bp, - strand
From Ensembl annotation of GRCm38

  46383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt7b

Human
homologs
Human Homolog WNT7B, wingless-type MMTV integration site family, member 7B
NCBI Gene ID 7477
neXtProt AC  NX_P56706
Human Chr (Location)  22q13; chr22:45920366-45977128 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Radiation induced(1) Targeted(8)
Genomic Mutations involving Wnt7b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.
 
Interactions
Wnt7b interacts with 193 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process activation of JUN kinase activity, anatomical structure regression, ...
Component cell surface, cytoplasm, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (157 records)
Data Summary: Results (996)    Tissues (535)    Images (174)
Theiler Stages: 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 899
Northern blot 21
Western blot 1
RT-PCR 68
RNase protection 2
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(89) cDNA(66) Primer pair(13) Other(10)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022382 (Evidence)
Entrez Gene22422 (Evidence)
UniGene306946
DFCITC1580998, TC1597352, TC1602291
DoTSDT.101725892, DT.530872, DT.97386548
NIA Mouse Gene IndexU036500
Consensus CDS ProjectCCDS37171.1, CCDS49691.1, CCDS49692.1
International Mouse Knockout Project StatusWnt7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022382 Ensembl Gene Model | MGI Sequence Detail 46383 C57BL/6J ±  kb
transcript ENSMUST00000109424 Ensembl | MGI Sequence Detail 3492 Not Applicable 
polypeptide ENSMUSP00000105051 Ensembl | MGI Sequence Detail 353 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013300 Wnt-7 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017449 protein Wnt-7b
References (Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:211687 Yeo EJ, et al., Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Res. 2014 Jun 1;74(11):2962-73
All references(215)
Other
accession IDs
MGD-MRK-15447, MGD-MRK-15457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory