Wnt7a
Gene Detail

Symbol Name ID

Wnt7a wingless-related MMTV integration site 7A MGI:98961

Synonyms

tw, Wnt-7a

Feature Type

protein coding gene

Genetic Map

Chromosome 6

40.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr6:91363981-91411363 bp, - strand From VEGA annotation of GRCm38   47383 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt7a

Human homologs

Human Homolog		WNT7A, wingless-type MMTV integration site family, member 7A
NCBI Gene ID		7476
neXtProt AC		NX_O00755
Human Chr (Location)		3p25; chr3:13860082-13921618 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human WNT7A

Alleles and phenotypes

All alleles(11) : Targeted(4) Gene trapped(2) Spontaneous(3) Chemically induced(2)
 

Homozygous mutants have skeletal abnormalities including absence of digits, especially of the forelimb, and sometimes absence of the ulna. Occasionally, there is an extra set of ribs. Both sexes are sterile due to abnormalities of the Mullerian duct.

 
Human Diseases Modeled Using Mouse Wnt7a (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	asymmetric protein localization, canonical Wnt receptor signaling pathway, ...
Component	cell surface, extracellular matrix, ...
Function	cytokine activity, frizzled binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (121 records)
Data Summary: Results (706)    Tissues (419)    Images (135)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	561
Northern blot	21
Western blot	1
RT-PCR	116
RNase protection	2

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(22) Primer pair(15) Other(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022158 (Evidence)
Ensembl Gene Model	ENSMUSG00000030093 (Evidence)
Entrez Gene	22421 (Evidence)
UniGene	56964
DFCI	TC1585136
DoTS	DT.60104472
NIA Mouse Gene Index	U027625
Consensus CDS Project	CCDS39568.1
International Mouse Knockout Project Status	Wnt7a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022158	VEGA Gene Model | MGI Sequence Detail	47383	C57BL/6J
transcript	OTTMUST00000052619	VEGA | MGI Sequence Detail	3172	Not Applicable
polypeptide	OTTMUSP00000024971	VEGA | MGI Sequence Detail	349	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(278 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013300	Wnt-7 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017448	protein Wnt-7a

References

(Earliest) J:15022 Russell LB, HR - tw legs. Mouse News Lett. 1957;17:84
(Latest) J:194480 Ma S, et al., Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469
All references(197)

Other accession IDs

MGD-MRK-13698, MGD-MRK-15446, MGD-MRK-15456, MGD-MRK-35364, MGI:2141500, MGI:97825