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Wnt7a
Gene Detail
 Symbol
Name
ID
Wnt7a
wingless-type MMTV integration site family, member 7A
MGI:98961
Synonyms tw, Wnt-7a
Feature Type protein coding gene
Genetic Map
Chromosome 6
40.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:91363981-91411363 bp, - strand
From VEGA annotation of GRCm38

  47383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt7a

Human
homologs
Human Homolog WNT7A, wingless-type MMTV integration site family, member 7A
NCBI Gene ID 7476
neXtProt AC  NX_O00755
Human Chr (Location)  3p25; chr3:13818585-13880121 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human WNT7A
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(2) Gene trapped(2) Spontaneous(3) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous mutants have skeletal abnormalities including absence of digits, especially of the forelimb, and sometimes absence of the ulna. Occasionally, there is an extra set of ribs. Both sexes are sterile due to abnormalities of the Mullerian duct.
 
Human Diseases Modeled Using Mouse Wnt7a (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Wnt7a interacts with 240 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process angiogenesis, asymmetric protein localization, ...
Component cell, cell surface, ...
Function cytokine activity, frizzled binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (125 records)
Data Summary: Results (951)    Tissues (576)    Images (145)
Theiler Stages: 1, 2, 3, 5, 8, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 810
Northern blot 21
Western blot 1
RT-PCR 112
RNase protection 2
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(1) cDNA(23) Primer pair(15) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022158 (Evidence)
Ensembl Gene ModelENSMUSG00000030093 (Evidence)
Entrez Gene22421 (Evidence)
UniGene56964
DFCITC1585136
DoTSDT.60104472
NIA Mouse Gene IndexU027625
Consensus CDS ProjectCCDS39568.1
International Mouse Knockout Project StatusWnt7a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022158 VEGA Gene Model | MGI Sequence Detail 47383 C57BL/6J ±  kb
transcript OTTMUST00000052619 VEGA | MGI Sequence Detail 3172 Not Applicable 
polypeptide OTTMUSP00000024971 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013300 Wnt-7 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017448 protein Wnt-7a
References (Earliest) J:15022 Russell LB, HR - tw legs. Mouse News Lett. 1957;17:84
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(203)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13698, MGD-MRK-15446, MGD-MRK-15456, MGD-MRK-35364, MGI:2141500, MGI:97825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory