About   Help   FAQ
Wnt7a Gene Detail
Summary
  • Symbol
    Wnt7a
  • Name
    wingless-type MMTV integration site family, member 7A
  • Synonyms
    tw, Wnt-7a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98961
    NCBI Gene: 22421
  • Gene Overview
    MyGene.info: WNT7A
Location & Maps
more
  • Sequence Map
    Chr6:91363981-91411363 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47383 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.45 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    WNT7A, Wnt family member 7A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WNT7A, Wnt family member 7A
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 7476
    neXtProt AC: NX_O00755

  • Chr Location
    3p25; chr3:13818217-13880121 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Wnt7a mouse models; 2 with human WNT7A associations

Human Disease Mouse Models
       Fibular Aplasia or Hypoplasia, Femoral Bowing and Poly-, Syn-, and Oligodactyly   OMIM: 228930 View 2 models
       Ulna and Fibula, Absence of, with Severe Limb Deficiency   OMIM: 276820
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 9 alleles in 10 genetic backgrounds
    12 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    2
  • Gene trapped
    2
  • Spontaneous
    4
  • Targeted
    5
  • Genomic Mutations
    2 involving Wnt7a
  • Incidental Mutations
    APF
Homozygous mutants have skeletal abnormalities including absence of digits, especially of the forelimb, and sometimes absence of the ulna. Occasionally, there is an extra set of ribs. Both sexes are sterile due to abnormalities of the Mullerian duct.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022158 VEGA Gene Model | MGI Sequence Detail 47383 C57BL/6J ±  kb
transcript OTTMUST00000052619 VEGA | MGI Sequence Detail 3172 Not Applicable  
polypeptide OTTMUSP00000024971 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    291 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 1
    cDNA 24
    Primer pair 15
    Other 6

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13698, MGD-MRK-15446, MGD-MRK-15456, MGD-MRK-35364, MGI:2141500, MGI:97825
References
more
  • Summaries
    All 208
    Developmental Gene Expression 135
    Diseases 2
    Gene Ontology 24
    Phenotypes 42
  • Earliest
    J:15022 Russell LB, HR - tw legs. Mouse News Lett. 1957;17:84
  • Latest
    J:229475 Prunskaite-Hyyrylainen R, et al., Wnt4 coordinates directional cell migration and extension of the Mullerian duct essential for ontogenesis of the female reproductive tract. Hum Mol Genet. 2016 Mar 15;25(6):1059-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory