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Wnt7a
Gene Detail
Symbol

Name
ID
Wnt7a
wingless-type MMTV integration site family, member 7A
MGI:98961
Synonyms
tw, Wnt-7a
Feature Type
protein coding gene
Genetic Map
Chromosome 6
40.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:91363981-91411363 bp, - strand
From VEGA annotation of GRCm38

  47383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT7A
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt7a

Human
homologs
WNT7A, wingless-type MMTV integration site family, member 7A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7476
neXtProt AC: NX_O00755

Human Chr (Location): 3p25; chr3:13818217-13880121 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human WNT7A

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(2) Spontaneous(4) Targeted(5)
Genomic Mutations involving Wnt7a (1)
Incidental mutations (data from APF )
 
Homozygous mutants have skeletal abnormalities including absence of digits, especially of the forelimb, and sometimes absence of the ulna. Occasionally, there is an extra set of ribs. Both sexes are sterile due to abnormalities of the Mullerian duct.
 
Human Diseases Modeled in Mice Using Wnt7a (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Wnt7a interacts with 240 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process angiogenesis, asymmetric protein localization, ...
Component cell, cell surface, ...
Function cytokine activity, frizzled binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (129 records)
Data Summary: Results (950)    Tissues (576)    Images (145)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 809
Northern blot 21
Western blot 1
RT-PCR 112
RNase protection 2
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT7A ; Xenbase LOC100497917 ; ZFIN wnt7aa    NEW 
Molecular
reagents
All nucleic(45) Genomic(1) cDNA(23) Primer pair(15) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022158 (Evidence)
Ensembl Gene Model ENSMUSG00000030093 (Evidence)
Entrez Gene 22421 (Evidence)
UniGene 56964
DFCI TC1585136
DoTS DT.60104472
NIA Mouse Gene Index U027625
Consensus CDS Project CCDS39568.1
International Mouse Phenotyping Consortium Status Wnt7a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022158 VEGA Gene Model | MGI Sequence Detail 47383 C57BL/6J ±  kb
transcript OTTMUST00000052619 VEGA | MGI Sequence Detail 3172 Not Applicable 
polypeptide OTTMUSP00000024971 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013300 Wnt-7 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017448 protein Wnt-7a
References
(Earliest) J:15022 Russell LB, HR - tw legs. Mouse News Lett. 1957;17:84
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(203)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13698, MGD-MRK-15446, MGD-MRK-15456, MGD-MRK-35364, MGI:2141500, MGI:97825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory