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Wnt6
Gene Detail
Symbol

Name
ID
Wnt6
wingless-type MMTV integration site family, member 6
MGI:98960
Synonyms
Wnt-6
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:74771892-74785322 bp, + strand
From VEGA annotation of GRCm38

  13431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: WNT6
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt6

Human
homologs
WNT6, wingless-type MMTV integration site family, member 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7475
neXtProt AC: NX_Q9Y6F9

Human Chr (Location): 2q35; chr2:218859823-218874233 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Wnt6 (1)
 
Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation.
 
Interactions
Wnt6 interacts with 88 markers (Mir1a-1, Mir1a-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process axis specification, branching involved in ureteric bud morphogenesis, ...
Component cell surface, extracellular region, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (78 records)
Data Summary: Results (491)    Tissues (382)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 407
Northern blot 16
RT-PCR 66
RNase protection 2
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT6    NEW 
Molecular
reagents
All nucleic(41) cDNA(27) Primer pair(10) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000048253 (Evidence)
Ensembl Gene Model ENSMUSG00000033227 (Evidence)
Entrez Gene 22420 (Evidence)
UniGene 268282
DFCI TC1588960, TC1660613
DoTS DT.487555, DT.50314912, DT.94207710
NIA Mouse Gene Index U042178
Consensus CDS Project CCDS15056.1
International Mouse Phenotyping Consortium Status Wnt6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048253 VEGA Gene Model | MGI Sequence Detail 13431 C57BL/6J ±  kb
transcript OTTMUST00000123853 VEGA | MGI Sequence Detail 2071 Not Applicable 
polypeptide OTTMUSP00000067525 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009143 Wnt-6 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017447 protein Wnt-6
References
(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:217590 Yuan G, et al., The non-canonical BMP and Wnt/beta-catenin signaling pathways orchestrate early tooth development. Development. 2015 Jan 1;142(1):128-39
All references(117)
Other
accession IDs
MGD-MRK-15445, MGD-MRK-15455, MGI:2138090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory