About   Help   FAQ
Wnt6
Gene Detail
Symbol

Name
ID
Wnt6
wingless-type MMTV integration site family, member 6
MGI:98960
Synonyms
Wnt-6
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:74771892-74785322 bp, + strand
From VEGA annotation of GRCm38

  13431 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt6

Human
homologs
Human Homolog WNT6, wingless-type MMTV integration site family, member 6
NCBI Gene ID 7475
neXtProt AC  NX_Q9Y6F9
Human Chr (Location)  2q35; chr2:218859823-218874232 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation.
 
Interactions
Wnt6 interacts with 89 markers (Mir1a-1, Mir1a-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process axis specification, branching involved in ureteric bud morphogenesis, ...
Component cell surface, extracellular region, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (491)    Tissues (382)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 407
Northern blot 16
RT-PCR 66
RNase protection 2
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(27) Primer pair(10) Other(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000048253 (Evidence)
Ensembl Gene ModelENSMUSG00000033227 (Evidence)
Entrez Gene22420 (Evidence)
UniGene268282
DFCITC1588960, TC1660613
DoTSDT.487555, DT.50314912, DT.94207710
NIA Mouse Gene IndexU042178
Consensus CDS ProjectCCDS15056.1
International Mouse Knockout Project StatusWnt6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048253 VEGA Gene Model | MGI Sequence Detail 13431 C57BL/6J ±  kb
transcript OTTMUST00000123853 VEGA | MGI Sequence Detail 2071 Not Applicable 
polypeptide OTTMUSP00000067525 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009143 Wnt-6 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017447 protein Wnt-6
References
(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(116)
Other
accession IDs
MGD-MRK-15445, MGD-MRK-15455, MGI:2138090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory