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Wnt6
Gene Detail
 Symbol
Name
ID
Wnt6
wingless-type MMTV integration site family, member 6
MGI:98960
Synonyms Wnt-6
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:74771892-74785319 bp, + strand
From NCBI annotation of GRCm38

  13428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt6

Human
homologs
Human Homolog WNT6, wingless-type MMTV integration site family, member 6
NCBI Gene ID 7475
neXtProt AC  NX_Q9Y6F9
Human Chr (Location)  2q35; chr2:218859823-218874232 (+)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process axis specification, branching involved in ureteric bud morphogenesis, ...
Component cell surface, extracellular matrix, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (495)    Tissues (381)    Images (84)
Theiler Stages: 1, 2, 3, 4, 5, 6, 8, 9, 11, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 405
Northern blot 16
RT-PCR 72
RNase protection 2
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) cDNA(26) Primer pair(10) Other(4)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000033227 (Evidence)
Entrez Gene22420 (Evidence)
UniGene268282
DFCITC1588960, TC1660613
DoTSDT.487555, DT.50314912, DT.94207710
NIA Mouse Gene IndexU042178
Consensus CDS ProjectCCDS15056.1
International Mouse Knockout Project StatusWnt6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22420 NCBI Gene Model | MGI Sequence Detail 13428 C57BL/6J ±  kb
transcript NM_009526 RefSeq | MGI Sequence Detail 2068 C57BL/6 
polypeptide P22727 UniProt | EBI | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009143 Wnt-6 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017447 protein Wnt-6
Graphical View of Protein Domain Structure
References (Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(114)
Other
accession IDs
MGD-MRK-15445, MGD-MRK-15455, MGI:2138090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory