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Wnt6 Gene Detail
Summary
  • Symbol
    Wnt6
  • Name
    wingless-type MMTV integration site family, member 6
  • Synonyms
    Wnt-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:98960
    NCBI Gene: 22420
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74771892-74785322 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98960
protein coding gene Chr1:74754342-74785322 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016162
protein coding gene Chr1:75382786-75395998 (+)
A/J MGP_AJ_G0016145
protein coding gene Chr1:72757371-72770761 (+)
AKR/J MGP_AKRJ_G0016102
protein coding gene Chr1:74763145-74776657 (+)
BALB/cJ MGP_BALBcJ_G0016100
protein coding gene Chr1:72812843-72826255 (+)
C3H/HeJ MGP_C3HHeJ_G0015931
protein coding gene Chr1:75108339-75121573 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016553
protein coding gene Chr1:78317581-78333912 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014274
protein coding gene Chr1:68321187-68335719 (+)
CAST/EiJ MGP_CASTEiJ_G0015515
protein coding gene Chr1:74430199-74445021 (+)
CBA/J MGP_CBAJ_G0015904
protein coding gene Chr1:80869549-80883019 (+)
DBA/2J MGP_DBA2J_G0016005
protein coding gene Chr1:72074317-72087725 (+)
FVB/NJ MGP_FVBNJ_G0016008
protein coding gene Chr1:71267981-71281288 (+)
LP/J MGP_LPJ_G0016077
protein coding gene Chr1:76498723-76512115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016028
protein coding gene Chr1:84249898-84264488 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016600
protein coding gene Chr1:74838885-74852283 (+)
PWK/PhJ MGP_PWKPhJ_G0015302
protein coding gene Chr1:71534860-71548365 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015080
protein coding gene Chr1:74205828-74220608 (+)
WSB/EiJ MGP_WSBEiJ_G0015577
protein coding gene Chr1:74649319-74662709 (+)



Homology
more
  • Human Ortholog
    WNT6, Wnt family member 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WNT6, Wnt family member 6
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 7475
    neXtProt AC: NX_Q9Y6F9
    UniProt: Q9Y6F9

  • Chr Location
    2q35; chr2:218859823-218874232 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033227 Ensembl Gene Model | MGI Sequence Detail 13431 C57BL/6J ±  kb
    transcript ENSMUST00000006716 Ensembl | MGI Sequence Detail 2071 Not Applicable  
    polypeptide ENSMUSP00000006716 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 28
      Primer pair 11
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15445, MGD-MRK-15455, MGI:2138090
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 89
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory