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Wnt5b
Gene Detail
Symbol

Name
ID
Wnt5b
wingless-type MMTV integration site family, member 5B
MGI:98959
Synonyms
Wnt-5b
Feature Type
protein coding gene
Genetic Map
Chromosome 6
56.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:119432531-119544318 bp, - strand
From VEGA annotation of GRCm38

  111788 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT5B
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt5b

Human
homologs
WNT5B, wingless-type MMTV integration site family, member 5B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 81029
neXtProt AC: NX_Q9H1J7

Human Chr (Location): 12p13.3; chr12:1529891-1647213 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes.
 
Interactions
Wnt5b interacts with 113 markers (Mir17, Mir19a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell-cell signaling, cell fate commitment, ...
Component cell surface, extracellular exosome, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (1061)    Tissues (570)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 924
Northern blot 29
RT-PCR 106
RNase protection 2
cDNA source data(50)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT5B ; Xenbase wnt5b ; ZFIN wnt5b    NEW 
Molecular
reagents
All nucleic(67) cDNA(53) Primer pair(11) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000027047 (Evidence)
Ensembl Gene Model ENSMUSG00000030170 (Evidence)
Entrez Gene 22419 (Evidence)
UniGene 321818
DFCI TC1581436, TC1722647, TC1762253
DoTS DT.101367707, DT.91592823, DT.94161050
NIA Mouse Gene Index U027798
Consensus CDS Project CCDS20474.2
International Mouse Phenotyping Consortium Status Wnt5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027047 VEGA Gene Model | MGI Sequence Detail 111788 C57BL/6J ±  kb
transcript OTTMUST00000066852 VEGA | MGI Sequence Detail 2339 Not Applicable 
polypeptide OTTMUSP00000033559 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(905 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR026537 Wnt-5b protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017446 protein Wnt-5b
References
(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(106)
Other
accession IDs
MGD-MRK-15444, MGD-MRK-15454, MGI:2141692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory