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Wnt5b Gene Detail
Summary
  • Symbol
    Wnt5b
  • Name
    wingless-type MMTV integration site family, member 5B
  • Synonyms
    Wnt-5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:98959
    NCBI Gene: 22419
  • Gene Overview
    MyGene.info: WNT5B
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119409492-119521308 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 56.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    882 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98959
protein coding gene Chr6:119409492-119521880 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031194
protein coding gene Chr6:122235553-122363336 (-)
A/J MGP_AJ_G0031163
protein coding gene Chr6:117554496-117667051 (-)
AKR/J MGP_AKRJ_G0031094
protein coding gene Chr6:120702009-120818855 (-)
BALB/cJ MGP_BALBcJ_G0031174
protein coding gene Chr6:117328873-117441379 (-)
C3H/HeJ MGP_C3HHeJ_G0030534
protein coding gene Chr6:63475485-63593365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031632
protein coding gene Chr6:125359649-125497236 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028793
protein coding gene Chr6:114473044-114490559 (-)
CAST/EiJ MGP_CASTEiJ_G0030281
protein coding gene Chr6:121150634-121272959 (-)
CBA/J MGP_CBAJ_G0030857
protein coding gene Chr6:130321296-130452143 (-)
DBA/2J MGP_DBA2J_G0031013
protein coding gene Chr6:116457082-116572302 (-)
FVB/NJ MGP_FVBNJ_G0030965
protein coding gene Chr6:115578996-115692132 (-)
LP/J MGP_LPJ_G0031092
protein coding gene Chr6:122243668-122366174 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030999
protein coding gene Chr6:134330404-134456716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031661
protein coding gene Chr6:120748310-120870499 (-)
PWK/PhJ MGP_PWKPhJ_G0029996
protein coding gene Chr6:115465288-115587965 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029825
protein coding gene Chr6:119463468-119589664 (-)
WSB/EiJ MGP_WSBEiJ_G0030364
protein coding gene Chr6:121017395-121143549 (-)



Homology
more
  • Human Ortholog
    WNT5B, Wnt family member 5B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT5B, Wnt family member 5B
  • Links
    NCBI Gene ID: 81029
    neXtProt AC: NX_Q9H1J7
    UniProt: Q9H1J7

  • Chr Location
    12p13.33; chr12:1617056-1647212 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    10 phenotype references
Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030170 Ensembl Gene Model | MGI Sequence Detail 111817 C57BL/6J ±  kb
transcript ENSMUST00000119369 Ensembl | MGI Sequence Detail 2339 Not Applicable  
polypeptide ENSMUSP00000112448 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    cDNA 54
    Primer pair 12
    Other 6

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15444, MGD-MRK-15454, MGI:2141692
References
more
  • Summaries
    All 134
    Developmental Gene Expression 88
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
  • Latest
    J:299734 Kishimoto K, et al., Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells. Nat Commun. 2020 Aug 27;11(1):4159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/08/2021
MGI 6.17
The Jackson Laboratory