Wnt5b
Gene Detail

Symbol Name ID

Wnt5b wingless-related MMTV integration site 5B MGI:98959

Synonyms

Wnt-5b

Feature Type

protein coding gene

Genetic Map

Chromosome 6

56.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:119432531-119544318 bp, - strand From VEGA annotation of GRCm38   111788 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt5b

Human homologs

Human Homolog		WNT5B, wingless-type MMTV integration site family, member 5B
NCBI Gene ID		81029
neXtProt AC		NX_Q9H1J7
Human Chr (Location)		12p13.3; chr12:1726222-1756378 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cell-cell signaling, cell fate commitment, ...
Component	cell surface, extracellular matrix, ...
Function	frizzled binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (60 records)
Data Summary: Results (814)    Tissues (356)    Images (87)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	671
Northern blot	29
RT-PCR	112
RNase protection	2

cDNA source data(48)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(51) Primer pair(11) Other(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000027047 (Evidence)
Ensembl Gene Model	ENSMUSG00000030170 (Evidence)
Entrez Gene	22419 (Evidence)
UniGene	321818
DFCI	TC1581436, TC1722647, TC1762253
DoTS	DT.101367707, DT.91592823, DT.94161050
NIA Mouse Gene Index	U027798
Consensus CDS Project	CCDS20474.2
International Mouse Knockout Project Status	Wnt5b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027047	VEGA Gene Model | MGI Sequence Detail	111788	C57BL/6J
transcript	OTTMUST00000066852	VEGA | MGI Sequence Detail	2339	Not Applicable
polypeptide	OTTMUSP00000033559	VEGA | MGI Sequence Detail	372	Not Applicable

All sequences(44) RefSeq(6) UniProt(2)

Polymorphisms

SNPs(167 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR026537	Wnt-5b protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017446	protein Wnt-5b

References

(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:193842 Lu C, et al., Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 2013 Apr;53(2):566-74
All references(102)

Other accession IDs

MGD-MRK-15444, MGD-MRK-15454, MGI:2141692