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Wnt5b Gene Detail
Summary
  • Symbol
    Wnt5b
  • Name
    wingless-type MMTV integration site family, member 5B
  • Synonyms
    Wnt-5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:98959
    NCBI Gene: 22419
  • Gene Overview
    MyGene.info: WNT5B
Location & Maps
more
  • Sequence Map
    Chr6:119432531-119544318 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      111788 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 56.86 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    WNT5B, Wnt family member 5B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT5B, Wnt family member 5B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 81029
    neXtProt AC: NX_Q9H1J7

  • Chr Location
    12p13.33; chr12:1529891-1647213 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027047 VEGA Gene Model | MGI Sequence Detail 111788 C57BL/6J ±  kb
transcript OTTMUST00000066852 VEGA | MGI Sequence Detail 2339 Not Applicable  
polypeptide OTTMUSP00000033559 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    899 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 53
    Primer pair 11
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15444, MGD-MRK-15454, MGI:2141692
References
more
  • Summaries
    All 109
    Developmental Gene Expression 70
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
  • Latest
    J:229484 Conte D, et al., The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Hum Mol Genet. 2016 Feb 15;25(4):740-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory