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Wnt4
Gene Detail
Symbol

Name
ID
Wnt4
wingless-type MMTV integration site family, member 4
MGI:98957
Synonyms
Wnt-4
Feature Type
protein coding gene
Genetic Map
Chromosome 4
69.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:137277489-137299726 bp, + strand
From VEGA annotation of GRCm38

  22238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT4
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt4

Human
homologs
WNT4, wingless-type MMTV integration site family, member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54361
neXtProt AC: NX_P56705

Human Synonyms: SERKAL, WNT-4

Human Chr (Location): 1p36.23-p35.1; chr1:22117305-22143981 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human WNT4

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Genomic Mutations involving Wnt4 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants exhibit impaired development of the kidney, pituitary gland, and female reproductive system. Mutants die within 24 hours of birth.
 
Phenotype Images(5)
Interactions
Wnt4 interacts with 288 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (109 annotations)
Process anatomical structure development, androgen biosynthetic process, ...
Component cell surface, cytoplasm, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (218 records)
Data Summary: Results (905)    Tissues (591)    Images (128)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 813
Northern blot 16
RT-PCR 74
RNase protection 2
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT4 ; Xenbase wnt4 ; ZFIN wnt4a, wnt4b    NEW 
Molecular
reagents
All nucleic(77) Genomic(2) cDNA(50) Primer pair(15) Other(10)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009828 (Evidence)
Ensembl Gene Model ENSMUSG00000036856 (Evidence)
Entrez Gene 22417 (Evidence)
UniGene 20355
DFCI TC1599329
DoTS DT.484192, DT.97354380
NIA Mouse Gene Index U004979, U004980
Consensus CDS Project CCDS18815.1
International Mouse Phenotyping Consortium Status Wnt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009828 VEGA Gene Model | MGI Sequence Detail 22238 C57BL/6J ±  kb
transcript OTTMUST00000022760 VEGA | MGI Sequence Detail 4194 Not Applicable 
polypeptide OTTMUSP00000010387 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009142 Wnt-4 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017444 protein Wnt-4
References
(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:220461 Kann M, et al., WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 1;142(7):1254-66
All references(315)
Other
accession IDs
MGD-MRK-15442, MGD-MRK-15452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory