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Wnt4
Gene Detail
 Symbol
Name
ID
Wnt4
wingless-type MMTV integration site family, member 4
MGI:98957
Synonyms Wnt-4
Feature Type protein coding gene
Genetic Map
Chromosome 4
69.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:137277489-137299726 bp, + strand
From VEGA annotation of GRCm38

  22238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt4

Human
homologs
Human Homolog WNT4, wingless-type MMTV integration site family, member 4
NCBI Gene ID 54361
neXtProt AC  NX_P56705
Human Synonyms  SERKAL, WNT-4
Human Chr (Location)  1p36.23-p35.1; chr1:22117305-22143026 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human WNT4
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit impaired development of the kidney, pituitary gland, and female reproductive system. Mutants die within 24 hours of birth.
 
Interactions
Wnt4 interacts with 288 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (110 annotations)
Process anatomical structure development, androgen biosynthetic process, ...
Component cell surface, cytoplasm, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (202 records)
Data Summary: Results (912)    Tissues (592)    Images (128)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 814
Northern blot 16
RT-PCR 80
RNase protection 2
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) Genomic(2) cDNA(50) Primer pair(15) Other(10)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009828 (Evidence)
Ensembl Gene ModelENSMUSG00000036856 (Evidence)
Entrez Gene22417 (Evidence)
UniGene20355
DFCITC1599329
DoTSDT.484192, DT.97354380
NIA Mouse Gene IndexU004979, U004980
Consensus CDS ProjectCCDS18815.1
International Mouse Knockout Project StatusWnt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009828 VEGA Gene Model | MGI Sequence Detail 22238 C57BL/6J ±  kb
transcript OTTMUST00000022760 VEGA | MGI Sequence Detail 4194 Not Applicable 
polypeptide OTTMUSP00000010387 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009142 Wnt-4 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017444 protein Wnt-4
References (Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(297)
Other
accession IDs
MGD-MRK-15442, MGD-MRK-15452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory