Wnt3a
Gene Detail

Symbol Name ID

Wnt3a wingless-related MMTV integration site 3A MGI:98956

Synonyms

Wnt-3a

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(27)

Sequence Map

Chr11:59248033-59290752 bp, - strand From VEGA annotation of GRCm38   42720 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt3a

Human homologs

Human Homolog		WNT3A, wingless-type MMTV integration site family, member 3A
NCBI Gene ID		89780
neXtProt AC		NX_P56704
Human Chr (Location)		1q42; chr1:228194723-228248972 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(6) Gene trapped(11) Spontaneous(1) Chemically induced(1)
 

Homozygous null mutants die at embryonic day 10.5-12.5 with failed development of caudal somites, notochord and structures rostral to hindlimbs. Homozygotes for a hypomorphic allele have vertebral defects and a short tail due to loss of caudal vertebrae.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (100 annotations)

Process	anterior/posterior pattern specification, axis elongation involved in somitogenesis, ...
Component	cell surface, extracellular region, ...
Function	frizzled-2 binding, frizzled binding, ...

External Resources: FuncBase

Expression

Literature Summary: (199 records)
Data Summary: Results (585)    Tissues (328)    Images (118)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	452
Northern blot	11
RT-PCR	120
RNase protection	2

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(3) cDNA(19) Primer pair(15) Other(13)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005791 (Evidence)
Ensembl Gene Model	ENSMUSG00000009900 (Evidence)
Entrez Gene	22416 (Evidence)
UniGene	1367
DFCI	TC1589485
DoTS	DT.60102684
NIA Mouse Gene Index	U032842
Consensus CDS Project	CCDS24766.1
International Mouse Knockout Project Status	Wnt3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005791	VEGA Gene Model | MGI Sequence Detail	42720	C57BL/6J
transcript	OTTMUST00000012817	VEGA | MGI Sequence Detail	2761	Not Applicable
polypeptide	OTTMUSP00000005961	VEGA | MGI Sequence Detail	352	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(173 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR009141	Wnt-3 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017443	protein Wnt-3a

References

(Earliest) J:13062 HESTON WE, The 'vestigial tail' mouse; a new recessive mutation. J Hered. 1951 Mar-Apr;42(2):71-4
(Latest) J:193783 Zhang R, et al., Wnt/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone. 2013 Jan;52(1):145-56
All references(381)

Other accession IDs

MGD-MRK-15417, MGD-MRK-15441, MGD-MRK-15451