About   Help   FAQ
Wnt3a Gene Detail
Summary
  • Symbol
    Wnt3a
  • Name
    wingless-type MMTV integration site family, member 3A
  • Synonyms
    Wnt-3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98956
    NCBI Gene: 22416
  • Gene Overview
    MyGene.info: WNT3A
Location & Maps
more
  • Sequence Map
    Chr11:59248033-59290752 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42720 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.17 cM
  • Mapping Data
    27 experiments
Homology
more
  • Human Ortholog
    WNT3A, Wnt family member 3A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT3A, Wnt family member 3A
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 89780
    neXtProt AC: NX_P56704

  • Chr Location
    1q42; chr1:228007022-228066711 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 5 alleles in 10 genetic backgrounds
    28 phenotypes from multigenic genotypes
    1 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Wnt3a
  • Incidental Mutations
Homozygous null mutants die at embryonic day 10.5-12.5 with failed development of caudal somites, notochord and structures rostral to hindlimbs. Homozygotes for a hypomorphic allele have vertebral defects and a short tail due to loss of caudal vertebrae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005791 VEGA Gene Model | MGI Sequence Detail 42720 C57BL/6J ±  kb
transcript OTTMUST00000012817 VEGA | MGI Sequence Detail 2761 Not Applicable  
polypeptide OTTMUSP00000005961 VEGA | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    374 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    Genomic 3
    cDNA 21
    Primer pair 15
    Other 16

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15417, MGD-MRK-15441, MGD-MRK-15451
References
more
  • Summaries
    All 444
    Developmental Gene Expression 238
    Gene Ontology 77
    Phenotypes 68
  • Earliest
    J:13062 HESTON WE, The 'vestigial tail' mouse; a new recessive mutation. J Hered. 1951 Mar-Apr;42(2):71-4
  • Latest
    J:229467 Zhang KK, et al., Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory