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Wnt3a
Gene Detail
Symbol

Name
ID
Wnt3a
wingless-type MMTV integration site family, member 3A
MGI:98956
Synonyms
Wnt-3a
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(27)
Sequence Map
Chr11:59248033-59290752 bp, - strand
From VEGA annotation of GRCm38

  42720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22528  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT3A
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt3a

Human
homologs
WNT3A, wingless-type MMTV integration site family, member 3A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 89780
neXtProt AC: NX_P56704

Human Chr (Location): 1q42; chr1:228007022-228066711 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(1) Gene trapped(11) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants die at embryonic day 10.5-12.5 with failed development of caudal somites, notochord and structures rostral to hindlimbs. Homozygotes for a hypomorphic allele have vertebral defects and a short tail due to loss of caudal vertebrae.
 
Phenotype Images(1)
Interactions
Wnt3a interacts with 182 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (106 annotations)
Process anterior/posterior pattern specification, axis elongation involved in somitogenesis, ...
Component cell surface, extracellular region, ...
Function frizzled-2 binding, frizzled binding, ...
External Resources: FuncBase
Expression
Literature Summary: (230 records)
Data Summary: Results (792)    Tissues (530)    Images (133)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 665
Northern blot 11
RT-PCR 114
RNase protection 2
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT3A ; Xenbase wnt3a ; ZFIN wnt3a    NEW 
Molecular
reagents
All nucleic(55) Genomic(3) cDNA(21) Primer pair(15) Other(16)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005791 (Evidence)
Ensembl Gene Model ENSMUSG00000009900 (Evidence)
Entrez Gene 22416 (Evidence)
UniGene 1367
DFCI TC1589485
DoTS DT.60102684
NIA Mouse Gene Index U032842
Consensus CDS Project CCDS24766.1
International Mouse Phenotyping Consortium Status Wnt3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005791 VEGA Gene Model | MGI Sequence Detail 42720 C57BL/6J ±  kb
transcript OTTMUST00000012817 VEGA | MGI Sequence Detail 2761 Not Applicable 
polypeptide OTTMUSP00000005961 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(375 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009141 Wnt-3 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017443 protein Wnt-3a
References
(Earliest) J:13062 HESTON WE, The 'vestigial tail' mouse; a new recessive mutation. J Hered. 1951 Mar-Apr;42(2):71-4
(Latest) J:222442 Li BI, et al., The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation. Dev Biol. 2015 Jun 1;402(1):17-31
All references(426)
Other
accession IDs
MGD-MRK-15417, MGD-MRK-15441, MGD-MRK-15451

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory