Wnt3
Gene Detail

Symbol Name ID

Wnt3 wingless-related MMTV integration site 3 MGI:98955

Synonyms

Int-4, Wnt-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)

Sequence Map

Chr11:103774150-103817957 bp, + strand From VEGA annotation of GRCm38   43808 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt3

Human homologs

Human Homolog		WNT3, wingless-type MMTV integration site family, member 3
NCBI Gene ID		7473
neXtProt AC		NX_P56703
Human Synonyms		INT4
Human Chr (Location)		17q21; chr17:44841686-44896082 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WNT3

Alleles and phenotypes

All alleles(11) : Targeted(9) Gene trapped(2)
 

Homozygous mutants develop to the egg cylinder stage, but fail to form a primitive streak, mesoderm, or node, and die by embryonic day 10.5.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	anatomical structure formation involved in morphogenesis, anterior/posterior axis specification, ...
Component	cytoplasm, extracellular matrix, ...
Function	frizzled binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (125 records)
Data Summary: Results (591)    Tissues (307)    Images (85)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	397
Northern blot	17
RT-PCR	170
RNase protection	2

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(66) Genomic(20) cDNA(25) Primer pair(16) Other(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003018 (Evidence)
Ensembl Gene Model	ENSMUSG00000000125 (Evidence)
Entrez Gene	22415 (Evidence)
UniGene	159091
DFCI	TC1586202
DoTS	DT.110547418, DT.40140176
NIA Mouse Gene Index	U013423
Consensus CDS Project	CCDS25523.1
International Mouse Knockout Project Status	Wnt3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003018	VEGA Gene Model | MGI Sequence Detail	43808	C57BL/6J
transcript	OTTMUST00000006193	VEGA | MGI Sequence Detail	3076	Not Applicable
polypeptide	OTTMUSP00000002923	VEGA | MGI Sequence Detail	355	Not Applicable

All sequences(30) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(7) : SNPs(262 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR009141	Wnt-3 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017442	proto-oncogene protein Wnt-3

References

(Earliest) J:9831 Buchberg AM, et al., A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989 May;122(1):153-61
(Latest) J:192194 Tortelote GG, et al., Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol. 2013 Feb 1;374(1):164-73
All references(206)

Other accession IDs

MGD-MRK-11421, MGD-MRK-15440, MGD-MRK-15450