About   Help   FAQ
Wnt3 Gene Detail
Summary
  • Symbol
    Wnt3
  • Name
    wingless-type MMTV integration site family, member 3
  • Synonyms
    Int-4, Wnt-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98955
    NCBI Gene: 22415
  • Gene Overview
    MyGene.info: WNT3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:103774150-103817957 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43808 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.50 cM
  • Mapping Data
    37 experiments
Homology
more
  • Human Ortholog
    WNT3, Wnt family member 3
  • Vertebrate Orthologs
    12
  • Human Ortholog
    WNT3, Wnt family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INT4, TETAMS
  • Links
    NCBI Gene ID: 7473
    neXtProt AC: NX_P56703
    UniProt: P56703

  • Chr Location
    17q21.31-q21.32; chr17:46762506-46818760 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants develop to the egg cylinder stage, but fail to form a primitive streak, mesoderm, or node, and die by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003018 VEGA Gene Model | MGI Sequence Detail 43808 C57BL/6J ±  kb
    transcript OTTMUST00000006193 VEGA | MGI Sequence Detail 3076 Not Applicable  
    polypeptide OTTMUSP00000002923 VEGA | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      339 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 20
      cDNA 27
      Primer pair 16
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11421, MGD-MRK-15440, MGD-MRK-15450
    References
    more
    • Summaries
      All 243
      Developmental Gene Expression 153
      Gene Ontology 19
      Phenotypes 32
    • Earliest
      J:9831 Buchberg AM, et al., A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989 May;122(1):153-61
    • Latest
      J:256001 Jung EM, et al., Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory