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Wnt3
Gene Detail
 Symbol
Name
ID
Wnt3
wingless-type MMTV integration site family, member 3
MGI:98955
Synonyms Int-4, Wnt-3
Feature Type protein coding gene
Genetic Map
Chromosome 11
67.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr11:103774150-103817957 bp, + strand
From VEGA annotation of GRCm38

  43808 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt3

Human
homologs
Human Homolog WNT3, wingless-type MMTV integration site family, member 3
NCBI Gene ID 7473
neXtProt AC  NX_P56703
Human Synonyms  INT4
Human Chr (Location)  17q21; chr17:46762506-46818760 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human WNT3
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants develop to the egg cylinder stage, but fail to form a primitive streak, mesoderm, or node, and die by embryonic day 10.5.
 
Interactions
Wnt3 interacts with 268 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process anatomical structure formation involved in morphogenesis, anterior/posterior axis specification, ...
Component cytoplasm, extracellular matrix, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (133 records)
Data Summary: Results (796)    Tissues (469)    Images (95)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 602
Northern blot 17
RT-PCR 170
RNase protection 2
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) Genomic(20) cDNA(27) Primer pair(16) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003018 (Evidence)
Ensembl Gene ModelENSMUSG00000000125 (Evidence)
Entrez Gene22415 (Evidence)
UniGene159091
DFCITC1586202
DoTSDT.110547418, DT.40140176
NIA Mouse Gene IndexU013423
Consensus CDS ProjectCCDS25523.1
International Mouse Knockout Project StatusWnt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003018 VEGA Gene Model | MGI Sequence Detail 43808 C57BL/6J ±  kb
transcript OTTMUST00000006193 VEGA | MGI Sequence Detail 3076 Not Applicable 
polypeptide OTTMUSP00000002923 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(5)
Polymorphisms RFLP(7) : SNPs within 2kb(341 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009141 Wnt-3 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017442 proto-oncogene Wnt-3
References (Earliest) J:9831 Buchberg AM, et al., A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989 May;122(1):153-61
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(214)
Other
accession IDs
MGD-MRK-11421, MGD-MRK-15440, MGD-MRK-15450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory