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Wnt3 Gene Detail
Summary
  • Symbol
    Wnt3
  • Name
    wingless-type MMTV integration site family, member 3
  • Synonyms
    Int-4, Wnt-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98955
    NCBI Gene: 22415
  • Gene Overview
    MyGene.info: WNT3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:103774150-103817957 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 67.50 cM
  • Mapping Data
    37 experiments
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98955
protein coding gene Chr11:103774150-103818021 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019269
protein coding gene Chr11:106882073-106925825 (+)
A/J MGP_AJ_G0019237
protein coding gene Chr11:102336663-102380586 (+)
AKR/J MGP_AKRJ_G0019206
protein coding gene Chr11:105483005-105527224 (+)
BALB/cJ MGP_BALBcJ_G0019211
protein coding gene Chr11:102775716-102819467 (+)
C3H/HeJ MGP_C3HHeJ_G0019020
protein coding gene Chr11:105711511-105755841 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019661
protein coding gene Chr11:110187683-110231631 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017286
protein coding gene Chr11:99748688-99792100 (+)
CAST/EiJ MGP_CASTEiJ_G0018574
protein coding gene Chr11:106704054-106781804 (+)
CBA/J MGP_CBAJ_G0018989
protein coding gene Chr11:114761424-114811778 (+)
DBA/2J MGP_DBA2J_G0019101
protein coding gene Chr11:101835622-101879484 (+)
FVB/NJ MGP_FVBNJ_G0019092
protein coding gene Chr11:101358655-101407168 (+)
LP/J MGP_LPJ_G0019170
protein coding gene Chr11:107368135-107414645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019122
protein coding gene Chr11:114101255-114145045 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019698
protein coding gene Chr11:105865828-105910779 (+)
PWK/PhJ MGP_PWKPhJ_G0018338
protein coding gene Chr11:102916511-102974270 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018129
protein coding gene Chr11:105617891-105663383 (+)
WSB/EiJ MGP_WSBEiJ_G0018623
protein coding gene Chr11:105872041-105916348 (+)



Homology
more
  • Human Ortholog
    WNT3, Wnt family member 3
  • Vertebrate Orthologs
    12
  • Human Ortholog
    WNT3, Wnt family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INT4, TETAMS
  • Links
    NCBI Gene ID: 7473
    neXtProt AC: NX_P56703
    UniProt: P56703

  • Chr Location
    17q21.31-q21.32; chr17:46762506-46818760 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants develop to the egg cylinder stage, but fail to form a primitive streak, mesoderm, or node, and die by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000125 Ensembl Gene Model | MGI Sequence Detail 43808 C57BL/6J ±  kb
    transcript ENSMUST00000000127 Ensembl | MGI Sequence Detail 3076 Not Applicable  
    polypeptide ENSMUSP00000000127 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 20
      cDNA 28
      Primer pair 16
      Other 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11421, MGD-MRK-15440, MGD-MRK-15450
    References
    more
    • Summaries
      All 247
      Developmental Gene Expression 156
      Gene Ontology 20
      Phenotypes 32
    • Earliest
      J:9831 Buchberg AM, et al., A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989 May;122(1):153-61
    • Latest
      J:262420 Szenker-Ravi E, et al., RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 2018 May;557(7706):564-569

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory