Wap
Gene Detail

Symbol Name ID

Wap whey acidic protein MGI:98943

Feature Type

protein coding gene

Genetic Map

Chromosome 11

4.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:6635482-6638637 bp, - strand From VEGA annotation of GRCm38   3156 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49274  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Protein SuperFamily: four-disulfide core domain protein, WAP type
Gene Tree: Wap

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change in WAP protein in YBR versus other strains.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	negative regulation of peptidase activity
Component	extracellular region
Function	nutrient reservoir activity, peptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(258)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(267) Genomic(5) cDNA(258) Primer pair(1) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005118 (Evidence)
Ensembl Gene Model	ENSMUSG00000000381 (Evidence)
Entrez Gene	22373 (Evidence)
UniGene	268094
DoTS	DT.55191380, DT.99841184
NIA Mouse Gene Index	U032498
Consensus CDS Project	CCDS24424.1
International Mouse Knockout Project Status	Wap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005118	VEGA Gene Model | MGI Sequence Detail	3156	C57BL/6J
transcript	OTTMUST00000011455	VEGA | MGI Sequence Detail	551	Not Applicable
polypeptide	OTTMUSP00000005333	VEGA | MGI Sequence Detail	134	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008197	Whey acidic protein, 4-disulphide core
Protein Ontology	PR:000017467	whey acidic protein

References

(Earliest) J:6634 Piletz JE, et al., Biochemical characterization of a novel whey protein from murine milk. J Biol Chem. 1981 Nov 25;256(22):11509-16
(Latest) J:184505 Oliver CH, et al., The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012 May 15;26(10):1086-97
All references(55)

Other accession IDs

MGD-MRK-15427