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Vtn
Gene Detail
Symbol

Name
ID
Vtn
vitronectin
MGI:98940
Synonyms
Vn
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:78499091-78502324 bp, + strand
From VEGA annotation of GRCm38

  3234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: VTN
Gene Tree: Vtn

Human
homologs
VTN, vitronectin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7448
neXtProt AC: NX_P04004

Human Synonyms: V75, VN, VNT

Human Chr (Location): 17q11; chr17:28367277-28370352 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Vtn (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes and heterozygotes for a targeted null mutation appear to develop, mature, and reproduce normally.
 
Interactions
Vtn interacts with 15 markers (Mir30c-1, Mir30c-2, Mir101c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell adhesion, cell adhesion mediated by integrin, ...
Component basement membrane, blood microparticle, ...
Function collagen binding, extracellular matrix binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (389)    Tissues (207)    Images (117)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 46
RNA in situ 316
RT-PCR 27
cDNA source data(421)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vtn ; ZFIN vtnb    NEW 
Molecular
reagents
All nucleic(433) Genomic(7) cDNA(422) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000143 (Evidence)
Ensembl Gene Model ENSMUSG00000017344 (Evidence)
Entrez Gene 22370 (Evidence)
UniGene 3667
DFCI TC1573543, TC1615296, TC1759893
DoTS DT.55107283, DT.94137733
NIA Mouse Gene Index U013021
Consensus CDS Project CCDS25106.1
International Mouse Phenotyping Consortium Status Vtn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000143 VEGA Gene Model | MGI Sequence Detail 3234 C57BL/6J ±  kb
transcript OTTMUST00000000458 VEGA | MGI Sequence Detail 1744 Not Applicable 
polypeptide OTTMUSP00000000198 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR020436 Somatomedin B, chordata
InterPro IPR001212 Somatomedin B domain
Protein Ontology PR:000017360 vitronectin
References
(Earliest) J:23999 Kolb WP, et al., The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex. J Exp Med. 1975 Apr 1;141(4):724-35
(Latest) J:217149 Katic J, et al., Interaction of the cell adhesion molecule CHL1 with vitronectin, integrins, and the plasminogen activator inhibitor-2 promotes CHL1-induced neurite outgrowth and neuronal migration. J Neurosci. 2014 Oct 29;34(44):14606-23
All references(85)
Other
accession IDs
MGD-MRK-15418, MGI:2144094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory