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Vtn
Gene Detail
Symbol

Name
ID
Vtn
vitronectin
MGI:98940
Synonyms
Vn
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:78499091-78502324 bp, + strand
From VEGA annotation of GRCm38

  3234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Vtn

Human
homologs
Human Homolog VTN, vitronectin
NCBI Gene ID 7448
neXtProt AC  NX_P04004
Human Synonyms  V75, VN, VNT
Human Chr (Location)  17q11; chr17:28367277-28370352 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes and heterozygotes for a targeted null mutation appear to develop, mature, and reproduce normally.
 
Interactions
Vtn interacts with 15 markers (Mir30c-1, Mir30c-2, Mir101c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell adhesion, cell adhesion mediated by integrin, ...
Component blood microparticle, extracellular matrix, ...
Function extracellular matrix binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (384)    Tissues (207)    Images (113)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 43
RNA in situ 316
RT-PCR 25
cDNA source data(421)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(432) Genomic(7) cDNA(422) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000143 (Evidence)
Ensembl Gene ModelENSMUSG00000017344 (Evidence)
Entrez Gene22370 (Evidence)
UniGene3667
DFCITC1573543, TC1615296, TC1759893
DoTSDT.55107283, DT.94137733
NIA Mouse Gene IndexU013021
Consensus CDS ProjectCCDS25106.1
International Mouse Knockout Project StatusVtn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000143 VEGA Gene Model | MGI Sequence Detail 3234 C57BL/6J ±  kb
transcript OTTMUST00000000458 VEGA | MGI Sequence Detail 1744 Not Applicable 
polypeptide OTTMUSP00000000198 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR020436 Somatomedin B, chordata
InterPro IPR001212 Somatomedin B domain
Protein Ontology PR:000017360 vitronectin
References
(Earliest) J:23999 Kolb WP, et al., The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex. J Exp Med. 1975 Apr 1;141(4):724-35
(Latest) J:194131 Sugiyama D, et al., TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
All references(85)
Other
accession IDs
MGD-MRK-15418, MGI:2144094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory