About   Help   FAQ
Vtn Gene Detail
Summary
  • Symbol
    Vtn
  • Name
    vitronectin
  • Synonyms
    Vn
  • Feature Type
    protein coding gene
  • IDs
    MGI:98940
    NCBI Gene: 22370
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78389946-78393151 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98940
protein coding gene Chr11:78389917-78393151 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018782
protein coding gene Chr11:79517549-79520782 (+)
A/J MGP_AJ_G0018748
protein coding gene Chr11:76470179-76473412 (+)
AKR/J MGP_AKRJ_G0018718
protein coding gene Chr11:78773841-78777074 (+)
BALB/cJ MGP_BALBcJ_G0018722
protein coding gene Chr11:76873284-76876517 (+)
C3H/HeJ MGP_C3HHeJ_G0018535
protein coding gene Chr11:78820787-78824020 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019173
protein coding gene Chr11:81986375-81989608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016808
protein coding gene Chr11:73440352-73443580 (+)
CAST/EiJ MGP_CASTEiJ_G0018089
protein coding gene Chr11:79276325-79280759 (+)
CBA/J MGP_CBAJ_G0018506
protein coding gene Chr11:85596383-85599616 (+)
DBA/2J MGP_DBA2J_G0018614
protein coding gene Chr11:76044868-76048101 (+)
FVB/NJ MGP_FVBNJ_G0018604
protein coding gene Chr11:75635110-75638300 (+)
LP/J MGP_LPJ_G0018685
protein coding gene Chr11:80032463-80035696 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018630
protein coding gene Chr11:85957558-85960791 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019213
protein coding gene Chr11:79021886-79025119 (+)
PWK/PhJ MGP_PWKPhJ_G0017860
protein coding gene Chr11:76841330-76844525 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017651
protein coding gene Chr11:78638380-78641556 (+)
WSB/EiJ MGP_WSBEiJ_G0018142
protein coding gene Chr11:78850600-78853791 (+)



Homology
more
  • Human Ortholog
    VTN, vitronectin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VTN, vitronectin
  • Synonyms
    V75, VN, VNT
  • Links
    NCBI Gene ID: 7448
    neXtProt AC: NX_P04004
    UniProt: P04004

  • Chr Location
    17q11.2; chr17:28367284-28373091 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with human VTN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes and heterozygotes for a targeted null mutation appear to develop, mature, and reproduce normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22370 NCBI Gene Model | MGI Sequence Detail 3206 C57BL/6J ±  kb
transcript NM_011707 RefSeq | MGI Sequence Detail 1763 ZRU/MplStud  
polypeptide P29788 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 440
    Genomic 7
    cDNA 425
    Primer pair 8

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15418, MGI:2144094
References
more
  • Summaries
    All 121
    Developmental Gene Expression 26
    Gene Ontology 12
    Phenotypes 39
  • Earliest
    J:23999 Kolb WP, et al., The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex. J Exp Med. 1975 Apr 1;141(4):724-35
  • Latest
    J:326151 Ayloo S, et al., Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier. Neuron. 2022 May 18;110(10):1641-1655.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory