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Vpreb2 Gene Detail
Summary
  • Symbol
    Vpreb2
  • Name
    pre-B lymphocyte gene 2
  • Synonyms
    Vpreb-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98937
    NCBI Gene: 22363
  • Gene Overview
    MyGene.info: VPREB1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr16:17798292-17799137 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.14 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98937
protein coding gene Chr16:17797314-17799138 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022562
protein coding gene Chr16:13960054-13960800 (-)
A/J MGP_AJ_G0022523
protein coding gene Chr16:13278125-13280441 (-)
AKR/J MGP_AKRJ_G0022501
protein coding gene Chr16:13821295-13823511 (-)
BALB/cJ MGP_BALBcJ_G0022564
protein coding gene Chr16:14566504-14573000 (+)
C3H/HeJ MGP_C3HHeJ_G0022332
protein coding gene Chr16:15145053-15145525 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022978
protein coding gene Chr16:14181831-14182333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020497
protein coding gene Chr16:13362215-13362961 (-)
CAST/EiJ MGP_CASTEiJ_G0021859
protein coding gene Chr16:15045588-15046886 (+)
CBA/J MGP_CBAJ_G0022264
protein coding gene Chr16:14842981-14845727 (-)
DBA/2J MGP_DBA2J_G0022432
protein coding gene Chr16:14327836-14328543 (+)
FVB/NJ MGP_FVBNJ_G0022408
protein coding gene Chr16:14378916-14379916 (+)
LP/J MGP_LPJ_G0022499
protein coding gene Chr16:14960095-14962056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022429
protein coding gene Chr16:15773599-15774328 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021565
protein coding gene Chr16:13455900-13456476 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021392
protein coding gene Chr16:13734233-13734978 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    VPREB1, V-set pre-B cell surrogate light chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPREB1, V-set pre-B cell surrogate light chain 1
  • Synonyms
    CD179a, IGI, IGVPB, VPREB
  • Links
    NCBI Gene ID: 7441
    neXtProt AC: NX_P12018
    UniProt: P12018

  • Chr Location
    22q11.22; chr22:22244780-22245515 (+)  GRCh38.p7

Human Diseases
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  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    83 phenotype references
Mice homozygous for null mutations at both Vpreb1 and Vpreb2 show impaired B-cell development. Fewer small pre-BII and immature B- cells are in bone marrow and numbers of B-cells in spleen and peritoneum are reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059280 Ensembl Gene Model | MGI Sequence Detail 846 C57BL/6J ±  kb
transcript ENSMUST00000075371 Ensembl | MGI Sequence Detail 759 Not Applicable  
polypeptide ENSMUSP00000074835 Ensembl | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 11
    Genomic 6
    cDNA 3
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-15410, MGD-MRK-15413
References
more
  • Summaries
    All 101
    Developmental Gene Expression 2
    Diseases 6
    Gene Ontology 2
    Phenotypes 83
  • Earliest
    J:8871 Kudo A, et al., A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 1987 Aug;6(8):2267-72
  • Latest
    J:306108 Karpinski BA, et al., Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. Dis Model Mech. 2022 Feb 1;15(2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory