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Vpreb1
Gene Detail
 Symbol
Name
ID
Vpreb1
pre-B lymphocyte gene 1
MGI:98936
Synonyms CD179a, Vpreb-1
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr16:16868402-16870843 bp, - strand
From VEGA annotation of GRCm38

  2442 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84741  Vertebrate Homology Class
1 human; 2 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: immunoglobulin iota-like chain
Gene Tree: Vpreb1

Human
homologs
Human Homolog VPREB1, pre-B lymphocyte 1
NCBI Gene ID 7441
neXtProt AC  NX_P12018
Human Synonyms  IGI, IGVPB, VPREB
Human Chr (Location)  22q11.22; chr22:22244788-22245514 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(31) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous null mutants have fewer cells with functional pre-B cell receptors. Double knockouts homozygous for null mutations at Vpreb1 and Vpreb2 show impaired B-cell development. Fewer B-cells are found in bone marrow, spleen and peritoneum.
 
Interactions
Vpreb1 interacts with 22 markers (Mir22, Mir208a, Mir208b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process B cell proliferation, cell morphogenesis, ...
Component external side of plasma membrane, plasma membrane
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (11)    Tissues (8)   
Theiler Stages: 21, 22, 23, 24, 25, 28
Assay TypeResults
RT-PCR 11
cDNA source data(5)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(12) cDNA(6) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017055 (Evidence)
Ensembl Gene ModelENSMUSG00000059305 (Evidence)
Entrez Gene22362 (Evidence)
DoTSDT.60101004
Consensus CDS ProjectCCDS27989.1
International Mouse Knockout Project StatusVpreb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017055 VEGA Gene Model | MGI Sequence Detail 2442 C57BL/6J ±  kb
transcript OTTMUST00000041309 VEGA | MGI Sequence Detail 766 Not Applicable 
polypeptide OTTMUSP00000018545 VEGA | MGI Sequence Detail 142 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(19 from dbSNP Build 137)    SNPs within 2kb including multiple locations(25)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
Protein Ontology PR:000001858 immunoglobulin iota chain
References (Earliest) J:8871 Kudo A, et al., A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 1987 Aug;6(8):2267-72
(Latest) J:188886 Knoll M, et al., The non-Ig parts of the VpreB and lambda5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor. J Immunol. 2012 Jun 15;188(12):6010-7
All references(48)
Other
accession IDs
MGD-MRK-15409, MGD-MRK-15412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory