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Vldlr Gene Detail
Summary
  • Symbol
    Vldlr
  • Name
    very low density lipoprotein receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:98935
    NCBI Gene: 22359
  • Gene Overview
    MyGene.info: VLDLR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:27216484-27254231 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37748 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 21.77 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    VLDLR, very low density lipoprotein receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VLDLR, very low density lipoprotein receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH
  • Links
    NCBI Gene ID: 7436
    neXtProt AC: NX_P98155
    UniProt: P98155

  • Chr Location
    9p24.2; chr9:2621679-2656103 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 443
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VLDLR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Vldlr mouse models; 1 with human VLDLR associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035962 VEGA Gene Model | MGI Sequence Detail 37748 C57BL/6J ±  kb
    transcript OTTMUST00000092260 VEGA | MGI Sequence Detail 7971 Not Applicable  
    polypeptide OTTMUSP00000050945 VEGA | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      359 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017305 very low-density lipoprotein receptor
    • InterPro Domains
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR011042 Six-bladed beta-propeller, TolB-like
      IPR032931 Very low-density lipoprotein receptor
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 2
      cDNA 118
      Primer pair 6
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-15401, MGI:2147441, MGI:2147548, MGI:2147687
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 42
      Diseases 1
      Gene Ontology 10
      Phenotypes 81
    • Earliest
      J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
    • Latest
      J:257569 Fu Z, et al., Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):3862-3870

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory