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Vldlr Gene Detail
Summary
  • Symbol
    Vldlr
  • Name
    very low density lipoprotein receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:98935
    NCBI Gene: 22359
Location & Maps
more
  • Sequence Map
    Chr19:27216484-27254231 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37748 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VLDLR, very low density lipoprotein receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VLDLR, very low density lipoprotein receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAMRQ1, CARMQ1, CHRMQ1, VLDLRCH
  • Links
    NCBI Gene ID: 7436
    neXtProt AC: NX_P98155

  • Chr Location
    9p24; chr9:2621679-2656100 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 443
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VLDLR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Vldlr mouse models; 1 with human VLDLR associations

Human Disease Mouse Models
       Macular Degeneration, Age-Related, 1; ARMD1   OMIM: 603075 View 1 model
       Cerebellar Ataxia, Mental Retardation, and Dysequilibrium Syndrome 1; CAMRQ1   OMIM: 224050
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    1
  • Targeted
    4
  • Incidental Mutations
Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035962 VEGA Gene Model | MGI Sequence Detail 37748 C57BL/6J ±  kb
transcript OTTMUST00000092260 VEGA | MGI Sequence Detail 7971 Not Applicable  
polypeptide OTTMUSP00000050945 VEGA | MGI Sequence Detail 873 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    360 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017305 very low-density lipoprotein receptor
  • InterPro Domains
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR000033 LDLR class B repeat
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR011042 Six-bladed beta-propeller, TolB-like
Molecular
Reagents
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  • All nucleic 125
    Genomic 2
    cDNA 117
    Primer pair 5
    Other 1

    Microarray probesets 11
Other
Accession IDs
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MGD-MRK-15401, MGI:2147441, MGI:2147548, MGI:2147687
References
more
  • Summaries
    All 154
    Developmental Gene Expression 40
    Diseases 2
    Gene Ontology 10
    Phenotypes 69
  • Earliest
    J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
  • Latest
    J:226558 Sun Y, et al., Nuclear receptor RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10401-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory