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Vldlr
Gene Detail
Symbol

Name
ID
Vldlr
very low density lipoprotein receptor
MGI:98935
Feature Type
protein coding gene
Genetic Map
Chromosome 19
21.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr19:27216484-27254231 bp, + strand
From VEGA annotation of GRCm38

  37748 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vldlr

Human
homologs
Human Homolog VLDLR, very low density lipoprotein receptor
NCBI Gene ID 7436
neXtProt AC  NX_P98155
Human Synonyms  CARMQ1, CHRMQ1, VLDLRCH
Human Chr (Location)  9p24; chr9:2621774-2654485 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human VLDLR
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation.
 
Human Diseases Modeled Using Mouse Vldlr (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Vldlr interacts with 467 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular response to hypoxia, cholesterol metabolic process, ...
Component apical part of cell, cell surface, ...
Function apolipoprotein binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (415)    Tissues (202)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 309
Northern blot 24
Western blot 14
RT-PCR 32
RNase protection 36
cDNA source data(114)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) Genomic(2) cDNA(117) Primer pair(5)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000035962 (Evidence)
Ensembl Gene ModelENSMUSG00000024924 (Evidence)
Entrez Gene22359 (Evidence)
UniGene4141
DFCITC1576484, TC1592911, TC1600802
DoTSDT.101293936, DT.102553173, DT.94215403, DT.97414562
NIA Mouse Gene IndexU019329
Consensus CDS ProjectCCDS29721.1, CCDS50411.1
International Mouse Knockout Project StatusVldlr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035962 VEGA Gene Model | MGI Sequence Detail 37748 C57BL/6J ±  kb
transcript OTTMUST00000092260 VEGA | MGI Sequence Detail 7971 Not Applicable 
polypeptide OTTMUSP00000050945 VEGA | MGI Sequence Detail 873 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(14) UniProt(13)
Polymorphisms
RFLP(4) : SNPs within 2kb(360 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000017305 very low-density lipoprotein receptor
References
(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:208769 Nakatani T, et al., The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells. Dev Biol. 2014 Apr 1;388(1):68-80
All references(154)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15401, MGI:2147441, MGI:2147548, MGI:2147687

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory