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Vldlr
Gene Detail
Symbol

Name
ID
Vldlr
very low density lipoprotein receptor
MGI:98935
Feature Type
protein coding gene
Genetic Map
Chromosome 19
21.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr19:27216484-27254231 bp, + strand
From VEGA annotation of GRCm38

  37748 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VLDLR
Gene Tree: Vldlr

Human
homologs
VLDLR, very low density lipoprotein receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7436
neXtProt AC: NX_P98155

Human Synonyms: CAMRQ1, CARMQ1, CHRMQ1, VLDLRCH

Human Chr (Location): 9p24; chr9:2621679-2656100 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VLDLR

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation.
 
Human Diseases Modeled in Mice Using Vldlr (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Vldlr interacts with 466 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular response to hypoxia, cholesterol metabolic process, ...
Component apical part of cell, cell surface, ...
Function apolipoprotein binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (415)    Tissues (202)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 309
Northern blot 24
Western blot 14
RT-PCR 32
RNase protection 36
cDNA source data(114)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase vldlr ; ZFIN vldlr    NEW 
Molecular
reagents
All nucleic(124) Genomic(2) cDNA(117) Primer pair(5)
Microarray probesets(11)
Other database
links
VEGA Gene Model OTTMUSG00000035962 (Evidence)
Ensembl Gene Model ENSMUSG00000024924 (Evidence)
Entrez Gene 22359 (Evidence)
UniGene 4141
DFCI TC1576484, TC1592911, TC1600802
DoTS DT.101293936, DT.102553173, DT.94215403, DT.97414562
NIA Mouse Gene Index U019329
Consensus CDS Project CCDS29721.1, CCDS50411.1
International Mouse Phenotyping Consortium Status Vldlr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035962 VEGA Gene Model | MGI Sequence Detail 37748 C57BL/6J ±  kb
transcript OTTMUST00000092260 VEGA | MGI Sequence Detail 7971 Not Applicable 
polypeptide OTTMUSP00000050945 VEGA | MGI Sequence Detail 873 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(14) UniProt(7)
Polymorphisms
RFLP(4) : SNPs within 2kb(360 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000017305 very low-density lipoprotein receptor
References
(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:219839 Hirota Y, et al., Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015 Feb 15;523(3):463-78
All references(154)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15401, MGI:2147441, MGI:2147548, MGI:2147687

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory