Vldlr
Gene Detail

Symbol Name ID

Vldlr very low density lipoprotein receptor MGI:98935

Feature Type

protein coding gene

Genetic Map

Chromosome 19

21.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr19:27216484-27254231 bp, + strand From VEGA annotation of GRCm38   37748 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Vldlr

Human homologs

Human Homolog		VLDLR, very low density lipoprotein receptor
NCBI Gene ID		7436
neXtProt AC		NX_P98155
Human Synonyms		CARMQ1, CHRMQ1, VLDLRCH
Human Chr (Location)		9p24; chr9:2621793-2654485 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human VLDLR

Alleles and phenotypes

All alleles(5) : Targeted(4) Chemically induced(1)
 

Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation.

 
Human Diseases Modeled Using Mouse Vldlr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cellular response to hypoxia, cholesterol metabolic process, ...
Component	apical part of cell, cell surface, ...
Function	apolipoprotein binding, calcium-dependent protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (405)    Tissues (201)    Images (50)
Theiler Stages: 17, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	309
Northern blot	24
RT-PCR	32
RNase protection	40

cDNA source data(112)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(122) Genomic(2) cDNA(115) Primer pair(5)
Microarray probesets(11)

Other database links

VEGA Gene Model	OTTMUSG00000035962 (Evidence)
Ensembl Gene Model	ENSMUSG00000024924 (Evidence)
Entrez Gene	22359 (Evidence)
UniGene	4141
DFCI	TC1576484, TC1592911, TC1600802
DoTS	DT.101293936, DT.102553173, DT.94215403, DT.97414562
NIA Mouse Gene Index	U019329
Consensus CDS Project	CCDS29721.1, CCDS50411.1
International Mouse Knockout Project Status	Vldlr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035962	VEGA Gene Model | MGI Sequence Detail	37748	C57BL/6J
transcript	OTTMUST00000092260	VEGA | MGI Sequence Detail	7971	Not Applicable
polypeptide	OTTMUSP00000050945	VEGA | MGI Sequence Detail	873	Not Applicable

All sequences(71) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(4) : SNPs(190 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000017305	very low-density lipoprotein receptor

References

(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:185190 Lutter S, et al., Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol. 2012 Jun 11;197(6):837-49
All references(139)

Other accession IDs

MGD-MRK-15401, MGI:2147441, MGI:2147548, MGI:2147687