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Vim Gene Detail
Summary
  • Symbol
    Vim
  • Name
    vimentin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98932
    NCBI Gene: 22352
  • Gene Overview
    MyGene.info: VIM
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:13574311-13582826 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 10.04 cM, cytoband A2
  • Mapping Data
    24 experiments
  • Sequence Tag
    D2Mit149
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98932
 protein coding gene Chr2:13573927-13582826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025357
 protein coding gene Chr2:11079884-11088791 (+)
A/J MGP_AJ_G0025334
 protein coding gene Chr2:10661409-10670278 (+)
AKR/J MGP_AKRJ_G0025303
 protein coding gene Chr2:10971497-10980400 (+)
BALB/cJ MGP_BALBcJ_G0025330
 protein coding gene Chr2:10653438-10662328 (+)
C3H/HeJ MGP_C3HHeJ_G0025090
 protein coding gene Chr2:10925044-10933930 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025772
 protein coding gene Chr2:11383017-11391785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023187
 protein coding gene Chr2:10274120-10282883 (+)
CAST/EiJ MGP_CASTEiJ_G0024553
 protein coding gene Chr2:10888010-10897800 (+)
CBA/J MGP_CBAJ_G0025069
 protein coding gene Chr2:11865211-11874107 (+)
DBA/2J MGP_DBA2J_G0025201
 protein coding gene Chr2:10555709-10564612 (+)
FVB/NJ MGP_FVBNJ_G0025163
 protein coding gene Chr2:10454845-10463757 (+)
LP/J MGP_LPJ_G0025287
 protein coding gene Chr2:10991032-10999920 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025195
 protein coding gene Chr2:11742839-11751730 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025830
 protein coding gene Chr2:10888267-10897164 (+)
PWK/PhJ MGP_PWKPhJ_G0024304
 protein coding gene Chr2:10444650-10454051 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024104
 protein coding gene Chr2:10925292-10934107 (+)
WSB/EiJ MGP_WSBEiJ_G0024623
 protein coding gene Chr2:10976945-10985711 (+)



Homology
more
  • Human Ortholog
    VIM, vimentin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VIM, vimentin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 7431
    neXtProt AC: NX_P08670
    UniProt: P08670

  • Chr Location
    10p13; chr10:17227935-17237593 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 2538
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: VIM
  • Gene Tree
    Vim
Human Diseases
more
  • Diseases
    1 with Vim mouse models; 1 with human VIM associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit impaired performance in motor coordination tests; cerebellum shows underdeveloped/abnormal Bergman glia and stunted, poorly branched Purkinje cells. Mutants are unable to survive experimental 75% reduction of kidney mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1031
  • Tissues
    300
  • cDNA Data
    715
  • Literature Summary
    339
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22352 NCBI Gene Model | MGI Sequence Detail 8516 C57BL/6J ±  kb
    transcript NM_011701 RefSeq | MGI Sequence Detail 1834 C57BL/6  
    polypeptide P20152 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 730
      Genomic 3
      cDNA 719
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15395
    References
    more
    • Summaries
      All 524
      Developmental Gene Expression 339
      Diseases 1
      Gene Ontology 31
      Phenotypes 69
    • Earliest
      J:29340 Jackson BW, et al., Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation. 1980;17(3):161-79
    • Latest
      J:298883 Ghosh A, et al., In Vivo Cell Fate Tracing Provides No Evidence for Mesenchymal to Epithelial Transition in Adult Fallopian Tube and Uterus. Cell Rep. 2020 May 12;31(6):107631
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/23/2021
    MGI 6.16     		The Jackson Laboratory