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Vim Gene Detail
Summary
  • Symbol
    Vim
  • Name
    vimentin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98932
    NCBI Gene: 22352
Location & Maps
more
  • Sequence Map
    Chr2:13573927-13582826 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8900 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VIM, vimentin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VIM, vimentin
    Orthology source: HomoloGene
  • Synonyms
    CTRCT30, HEL113
  • Links
    NCBI Gene ID: 7431
    neXtProt AC: NX_P08670

  • Chr Location
    10p13; chr10:17227935-17237593 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2538
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VIM
  • Gene Tree
    Vim
Human Diseases
more
  • Diseases
    1 with human VIM associations

Human Disease Mouse Models
       Cataract 30; CTRCT30   OMIM: 116300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    4
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Homozygous null mutants exhibit impaired performance in motor coordination tests; cerebellum shows underdeveloped/abnormal Bergman glia and stunted, poorly branched Purkinje cells. Mutants are unable to survive experimental 75% reduction of kidney mass.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011231 VEGA Gene Model | MGI Sequence Detail 8900 C57BL/6J ±  kb
transcript OTTMUST00000026365 VEGA | MGI Sequence Detail 2193 Not Applicable  
polypeptide OTTMUSP00000012058 VEGA | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000017298 vimentin
  • InterPro Domains
    IPR006821 Intermediate filament head, DNA-binding domain
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR027699 Vimentin
Molecular
Reagents
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  • All nucleic 728
    Genomic 3
    cDNA 717
    Primer pair 5
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-15395
References
more
  • Summaries
    All 357
    Developmental Gene Expression 220
    Gene Ontology 27
    Phenotypes 52
  • Earliest
    J:29340 Jackson BW, et al., Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation. 1980;17(3):161-79
  • Latest
    J:224823 Chen AC, et al., Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11714-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory