Vim MGI Mouse Gene Detail - MGI:98932

Vim Gene Detail

Symbol

Vim
Name

vimentin

Feature Type

protein coding gene
IDs

MGI:98932
NCBI Gene: 22352
Gene Overview

MyGene.info: VIM

Sequence Map

Chr2:13573927-13582826 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

8900 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 10.04 cM, cytoband A2
Mapping Data

24 experiments
Sequence Tag

D2Mit149

Human Ortholog

VIM, vimentin

Vertebrate Orthologs

9

Human Ortholog

VIM, vimentin
Orthology source: HomoloGene, HGNC
Synonyms

CTRCT30, HEL113
Links

HGNC:12692

NCBI Gene ID: 7431

neXtProt AC: NX_P08670

UniProt: P08670
Chr Location

10p13; chr10:17227935-17237593 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2538
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: VIM
Gene Tree

Vim

Diseases

1 with human VIM associations

				Human Disease	Mouse Models
				cataract 30 IDs cataract 30 DOID:0110248 ICD10CM:Q12.0 OMIM:116300 ORDO:98984

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

39 phenotypes from 3 alleles in 3 genetic backgrounds
25 phenotypes from multigenic genotypes
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

4
Targeted

5
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available

Homozygous null mutants exhibit impaired performance in motor coordination tests; cerebellum shows underdeveloped/abnormal Bergman glia and stunted, poorly branched Purkinje cells. Mutants are unable to survive experimental 75% reduction of kidney mass.

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All GO Annotations

54
GO References

27

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

276
Tissues

245
cDNA Data

713
Literature Summary

241

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vim, vim.2

ZFIN vim

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Vim interacts with 108 markers (Mir7-2, Mir7b, Mir17, ...) View All

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All Sequences

91
RefSeq

2
UniProt

11
CCDS

CCDS15696.1
UniGene

268000

			Length	Strain/Species	Flank
genomic	OTTMUSG00000011231	VEGA Gene Model \| MGI Sequence Detail	8900	C57BL/6J	± kb
transcript	OTTMUST00000026365	VEGA \| MGI Sequence Detail	2193	Not Applicable
polypeptide	OTTMUSP00000012058	VEGA \| MGI Sequence Detail	466	Not Applicable

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SNPs within 2kb

76 from dbSNP Build 142

RFLP

5

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UniProt

11 Sequences
Protein Ontology

PR:000017298 vimentin

(term hierarchy)
InterPro Domains

IPR006821 Intermediate filament head, DNA-binding domain

IPR001664 Intermediate filament protein

IPR018039 Intermediate filament protein, conserved site

IPR027699 Vimentin

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All nucleic 728

Genomic 3

cDNA 717

Primer pair 5

Other 3

Microarray probesets 5

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MGD-MRK-15395

Summaries

All 385

Developmental Gene Expression 241

Gene Ontology 27

Phenotypes 53
Earliest

J:29340 Jackson BW, et al., Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation. 1980;17(3):161-79
Latest

J:240858 Driver AM, et al., Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain. Neurobiol Dis. 2016 Jul;91:69-82

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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