Vim
Gene Detail

Symbol Name ID

Vim vimentin MGI:98932

STS

D2Mit149

Feature Type

protein coding gene

Genetic Map

Chromosome 2

10.04 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr2:13573927-13582826 bp, + strand From VEGA annotation of GRCm38   8900 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Vim

Human homologs

Human Homolog		VIM, vimentin
NCBI Gene ID		7431
neXtProt AC		NX_P08670
Human Chr (Location)		10p13; chr10:17270258-17279592 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human VIM

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(4)
 

Homozygous null mutants exhibit impaired performance in motor coordination tests; cerebellum shows underdeveloped/abnormal Bergman glia and stunted, poorly branched Purkinje cells. Mutants are unable to survive experimental 75% reduction of kidney mass.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	astrocyte development, Bergmann glial cell differentiation, ...
Component	axon, cell body, ...
Function	identical protein binding, kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (166 records)
Data Summary: Results (188)    Tissues (166)    Images (38)
Theiler Stages: 1, 3, 4, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	25
RNA in situ	133
Northern blot	7
Western blot	6
RT-PCR	17

cDNA source data(691)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(706) Genomic(3) cDNA(695) Primer pair(5) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000011231 (Evidence)
Ensembl Gene Model	ENSMUSG00000026728 (Evidence)
Entrez Gene	22352 (Evidence)
UniGene	268000
DFCI	TC1573706, TC1614464, TC1751260, TC1760544
DoTS	DT.110664621, DT.110664645, DT.55184028, DT.94300691, DT.94393491, DT.97389709, DT.97395358
NIA Mouse Gene Index	U001401
Consensus CDS Project	CCDS15696.1
International Mouse Knockout Project Status	Vim

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011231	VEGA Gene Model | MGI Sequence Detail	8900	C57BL/6J
transcript	OTTMUST00000026365	VEGA | MGI Sequence Detail	2193	Not Applicable
polypeptide	OTTMUSP00000012058	VEGA | MGI Sequence Detail	466	Not Applicable

All sequences(89) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(5) : SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR006821	Intermediate filament head, DNA-binding domain
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
Protein Ontology	PR:000017298	vimentin

References

(Earliest) J:29340 Jackson BW, et al., Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation. 1980;17(3):161-79
(Latest) J:194893 Yu K, et al., Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
All references(292)

Other accession IDs

MGD-MRK-15395