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Vil1 Gene Detail
Summary
  • Symbol
    Vil1
  • Name
    villin 1
  • Synonyms
    Villin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98930
    NCBI Gene: 22349
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74409384-74435560 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C5
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98930
protein coding gene Chr1:74409376-74435560 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016151
protein coding gene Chr1:75008415-75034543 (+)
A/J MGP_AJ_G0016134
protein coding gene Chr1:72379776-72408221 (+)
AKR/J MGP_AKRJ_G0016091
protein coding gene Chr1:74394767-74421130 (+)
BALB/cJ MGP_BALBcJ_G0016089
protein coding gene Chr1:72449154-72475367 (+)
C3H/HeJ MGP_C3HHeJ_G0015920
protein coding gene Chr1:74725000-74755879 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016542
protein coding gene Chr1:77925307-77956910 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014263
protein coding gene Chr1:67968434-67994741 (+)
CAST/EiJ MGP_CASTEiJ_G0015504
protein coding gene Chr1:74056427-74084112 (+)
CBA/J MGP_CBAJ_G0015893
protein coding gene Chr1:80454497-80484505 (+)
DBA/2J MGP_DBA2J_G0015994
protein coding gene Chr1:71716051-71742642 (+)
FVB/NJ MGP_FVBNJ_G0015997
protein coding gene Chr1:70895166-70924518 (+)
LP/J MGP_LPJ_G0016066
protein coding gene Chr1:76115365-76143663 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016017
protein coding gene Chr1:83871609-83898217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016589
protein coding gene Chr1:74461257-74490087 (+)
PWK/PhJ MGP_PWKPhJ_G0015291
protein coding gene Chr1:71169861-71196520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015069
protein coding gene Chr1:73833205-73860585 (+)
WSB/EiJ MGP_WSBEiJ_G0015566
protein coding gene Chr1:74257925-74285355 (+)



Homology
more
  • Human Ortholog
    VIL1, villin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VIL1, villin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D2S1471, VIL
  • Links
    NCBI Gene ID: 7429
    neXtProt AC: NX_P09327
    UniProt: P09327

  • Chr Location
    2q35; chr2:218419115-218449525 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5169
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VIL1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Vil1
  • Incidental Mutations
  • Find Mice (IMSR)
  • Recombinase Activity
Homozygous null mutants do not exhibit gross abnormalities or apparent defects of microvilli morphogenesis, however in one line, an increased sensitivity to colitis induced by dextran sulfate was observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22349 NCBI Gene Model | MGI Sequence Detail 26177 C57BL/6J ±  kb
transcript NM_009509 RefSeq | MGI Sequence Detail 3117 C57BL/6  
polypeptide Q62468 UniProt | EBI | MGI Sequence Detail 827 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 16
    Primer pair 2
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15393
References
more
  • Summaries
    All 124
    Developmental Gene Expression 40
    Gene Ontology 10
    Phenotypes 23
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:263185 Huang M, et al., Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory