About   Help   FAQ
Vcl Gene Detail
Summary
  • Symbol
    Vcl
  • Name
    vinculin
  • Synonyms
    metavinculin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98927
    NCBI Gene: 22330
  • Gene Overview
    MyGene.info: VCL
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20929398-21033676 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98927
protein coding gene Chr14:20929378-21033676 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021049
protein coding gene Chr14:13731157-13834111 (+)
A/J MGP_AJ_G0020998
protein coding gene Chr14:13386233-13491651 (+)
AKR/J MGP_AKRJ_G0020975
protein coding gene Chr14:13920539-14025987 (+)
BALB/cJ MGP_BALBcJ_G0021001
protein coding gene Chr14:13495179-13594946 (+)
C3H/HeJ MGP_C3HHeJ_G0020785
protein coding gene Chr14:13862739-13965630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021434
protein coding gene Chr14:14210632-14313535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019002
protein coding gene Chr14:13702409-13799287 (+)
CAST/EiJ MGP_CASTEiJ_G0020309
protein coding gene Chr14:13647138-13746891 (+)
CBA/J MGP_CBAJ_G0020751
protein coding gene Chr14:14937190-15048880 (+)
DBA/2J MGP_DBA2J_G0020874
protein coding gene Chr14:13212961-13317534 (+)
FVB/NJ MGP_FVBNJ_G0020857
protein coding gene Chr14:13105370-13206638 (+)
LP/J MGP_LPJ_G0020950
protein coding gene Chr14:13938417-14047899 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020883
protein coding gene Chr14:14699013-14812757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021467
protein coding gene Chr14:13709722-13816861 (+)
PWK/PhJ MGP_PWKPhJ_G0020058
protein coding gene Chr14:12784628-12893512 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019880
protein coding gene Chr14:13504265-13611123 (+)
WSB/EiJ MGP_WSBEiJ_G0020365
protein coding gene Chr14:13696636-13802202 (+)



Homology
more
  • Human Ortholog
    VCL, vinculin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VCL, vinculin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMD1W, CMH15, HEL114, MV, MVCL
  • Links
    NCBI Gene ID: 7414
    neXtProt AC: NX_P18206
    UniProt: P18206

  • Chr Location
    10q22.2; chr10:73998114-74120160 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human VCL associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021823 Ensembl Gene Model | MGI Sequence Detail 104279 C57BL/6J ±  kb
    transcript ENSMUST00000022369 Ensembl | MGI Sequence Detail 5267 Not Applicable  
    polypeptide ENSMUSP00000022369 Ensembl | MGI Sequence Detail 1066 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 1
      cDNA 136
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826
    References
    more
    • Summaries
      All 163
      Developmental Gene Expression 72
      Gene Ontology 26
      Phenotypes 14
    • Earliest
      J:10655 Weller PA, et al., Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71
    • Latest
      J:278242 Xia M, et al., HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 2019 Jul 4;146(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory