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Vcl
Gene Detail
 Symbol
Name
ID
Vcl
vinculin
MGI:98927
Synonyms metavinculin
Feature Type protein coding gene
Genetic Map
Chromosome 14
11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:20929433-21033673 bp, + strand
From NCBI annotation of GRCm38

  104241 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7594  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: meta-vinculin
Gene Tree: Vcl

Human
homologs
Human Homolog VCL, vinculin
NCBI Gene ID 7414
neXtProt AC  NX_P18206
Human Synonyms  CMD1W, CMH15, HEL114, MV, MVCL
Human Chr (Location)  10q22.2; chr10:73998078-74120160 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human VCL
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart.
 
Phenotype Images(1)
Interactions
Vcl interacts with 300 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process adherens junction assembly, apical junction assembly, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (135)    Tissues (59)    Images (13)
Theiler Stages: 12, 14, 15, 17, 20, 23, 24, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 4
Western blot 29
RT-PCR 96
cDNA source data(135)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) Genomic(1) cDNA(135) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021823 (Evidence)
Entrez Gene22330 (Evidence)
UniGene279361
DFCITC1572867
NIA Mouse Gene IndexU015370
Consensus CDS ProjectCCDS26860.1
International Mouse Knockout Project StatusVcl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22330 NCBI Gene Model | MGI Sequence Detail 104241 C57BL/6J ±  kb
transcript NM_009502 RefSeq | MGI Sequence Detail 5229 C57BL/6 
polypeptide Q64727 UniProt | EBI | MGI Sequence Detail 1066 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(516 from dbSNP Build 137)    SNPs within 2kb including multiple locations(518)
Protein-related
information
ResourceIDDescription
InterPro IPR017997 Vinculin
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR000633 Vinculin, conserved site
Protein Ontology PR:000017272 vinculin
Graphical View of Protein Domain Structure
References (Earliest) J:10655 Weller PA, et al., Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71
(Latest) J:209602 Li CL, et al., SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014 Mar 12;34(11):4027-42
All references(116)
Other
accession IDs
MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory