Vcl
Gene Detail

Symbol Name ID

Vcl vinculin MGI:98927

Synonyms

metavinculin

Feature Type

protein coding gene

Genetic Map

Chromosome 14

11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:20929433-21033673 bp, + strand From NCBI annotation of GRCm38   104241 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7594  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: meta-vinculin
Gene Tree: Vcl

Human homologs

Human Homolog		VCL, vinculin
NCBI Gene ID		7414
neXtProt AC		NX_P18206
Human Synonyms		CMD1W, CMH15, MVCL
Human Chr (Location)		10q22.2; chr10:75757872-75879918 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human VCL

Alleles and phenotypes

All alleles(15) : Targeted(4) Gene trapped(11)
 

Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	adherens junction assembly, apical junction assembly, ...
Component	actin cytoskeleton, actin filament, ...
Function	alpha-catenin binding, dystroglycan binding, ...

External Resources: FuncBase

Expression

Literature Summary: (43 records)
Data Summary: Results (120)    Tissues (53)    Images (6)
Theiler Stages: 17, 20, 23, 24, 28

Assay Type	Results
RNA in situ	4
Western blot	24
RT-PCR	92

cDNA source data(141)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(144) Genomic(1) cDNA(141) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000021823 (Evidence)
Entrez Gene	22330 (Evidence)
UniGene	279361
DFCI	TC1572867
NIA Mouse Gene Index	U015370
Consensus CDS Project	CCDS26860.1
International Mouse Knockout Project Status	Vcl

Sequences

Length	Strain/Species
genomic	22330	NCBI Gene Model | MGI Sequence Detail	104241	C57BL/6J
transcript	NM_009502	RefSeq | MGI Sequence Detail	5229	C57BL/6
polypeptide	Q64727	UniProt | EBI | MGI Sequence Detail	1066	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(454 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017997	Vinculin
InterPro	IPR006077	Vinculin/alpha-catenin
InterPro	IPR000633	Vinculin, conserved site
Protein Ontology	PR:000017272	vinculin

Graphical View of Protein Domain Structure

References

(Earliest) J:10655 Weller PA, et al., Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71
(Latest) J:191071 Petzold KM, et al., Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas. Development. 2013 Jan 1;140(1):126-35
All references(99)

Other accession IDs

MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826