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Vcl
Gene Detail
Symbol

Name
ID
Vcl
vinculin
MGI:98927
Synonyms
metavinculin
Feature Type
protein coding gene
Genetic Map
Chromosome 14
11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:20929433-21033673 bp, + strand
From Ensembl annotation of GRCm38

  104241 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7594  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VCL
Protein SuperFamily: meta-vinculin
Gene Tree: Vcl

Human
homologs
VCL, vinculin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7414
neXtProt AC: NX_P18206

Human Synonyms: CMD1W, CMH15, HEL114, MV, MVCL

Human Chr (Location): 10q22.2; chr10:73998078-74120160 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human VCL

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart.
 
Phenotype Images(1)
Interactions
Vcl interacts with 300 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process adherens junction assembly, apical junction assembly, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (135)    Tissues (59)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 4
Western blot 29
RT-PCR 96
cDNA source data(135)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vcl ; ZFIN vcla    NEW 
Molecular
reagents
All nucleic(139) Genomic(1) cDNA(135) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000021823 (Evidence)
Entrez Gene 22330 (Evidence)
UniGene 279361
DFCI TC1572867
NIA Mouse Gene Index U015370
Consensus CDS Project CCDS26860.1
International Mouse Phenotyping Consortium Status Vcl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021823 Ensembl Gene Model | MGI Sequence Detail 104241 C57BL/6J ±  kb
transcript ENSMUST00000022369 Ensembl | MGI Sequence Detail 5229 Not Applicable 
polypeptide ENSMUSP00000022369 Ensembl | MGI Sequence Detail 1066 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(516 from dbSNP Build 137)    SNPs within 2kb including multiple locations(518)
Protein-related
information
ResourceIDDescription
InterPro IPR017997 Vinculin
InterPro IPR006077 Vinculin/alpha-catenin
InterPro IPR000633 Vinculin, conserved site
Protein Ontology PR:000017272 vinculin
References
(Earliest) J:10655 Weller PA, et al., Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71
(Latest) J:218531 Jannie KM, et al., Vinculin-dependent actin bundling regulates cell migration and traction forces. Biochem J. 2015 Feb 1;465(3):383-93
All references(123)
Other
accession IDs
MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory