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Vcl Gene Detail
Summary
  • Symbol
    Vcl
  • Name
    vinculin
  • Synonyms
    metavinculin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98927
    NCBI Gene: 22330
  • Gene Overview
    MyGene.info: VCL
Location & Maps
more
  • Sequence Map
    Chr14:20929433-21033673 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      104241 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VCL, vinculin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VCL, vinculin
    Orthology source: HomoloGene
  • Synonyms
    CMD1W, CMH15, HEL114, MV, MVCL
  • Links
    NCBI Gene ID: 7414
    neXtProt AC: NX_P18206

  • Chr Location
    10q22.2; chr10:73998078-74120160 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human VCL associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1w; CMD1W   OMIM: 611407
Cardiomyopathy, Familial Hypertrophic, 15; CMH15   OMIM: 613255
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021823 Ensembl Gene Model | MGI Sequence Detail 104241 C57BL/6J ±  kb
transcript ENSMUST00000022369 Ensembl | MGI Sequence Detail 5229 Not Applicable  
polypeptide ENSMUSP00000022369 Ensembl | MGI Sequence Detail 1066 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    518 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 139
    Genomic 1
    cDNA 135
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826
References
more
  • Summaries
    All 126
    Developmental Gene Expression 56
    Gene Ontology 23
    Phenotypes 11
  • Earliest
    J:10655 Weller PA, et al., Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71
  • Latest
    J:218531 Jannie KM, et al., Vinculin-dependent actin bundling regulates cell migration and traction forces. Biochem J. 2015 Feb 1;465(3):383-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory