Vcam1
Gene Detail

Symbol Name ID

Vcam1 vascular cell adhesion molecule 1 MGI:98926

Synonyms

CD106, Vcam-1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

50.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:116110020-116129688 bp, - strand From NCBI annotation of GRCm38   19669 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular cell adhesion protein 1
Gene Tree: Vcam1

Human homologs

Human Homolog		VCAM1, vascular cell adhesion molecule 1
NCBI Gene ID		7412
neXtProt AC		NX_P19320
Human Synonyms		CD106, INCAM-100
Human Chr (Location)		1p32-p31; chr1:101185196-101204601 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cell adhesion, cell-cell adhesion, ...
Component	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex, anchored to membrane, ...
Function	cell adhesion molecule binding, integrin binding

External Resources: FuncBase

Expression

Literature Summary: (71 records)
Data Summary: Results (95)    Tissues (56)    Images (43)
Theiler Stages: 11, 12, 13, 15, 19, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	46
RNA in situ	45
RT-PCR	4

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(13) cDNA(28) Primer pair(2)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000027962 (Evidence)
Entrez Gene	22329 (Evidence)
DFCI	TC1574873, TC1582765, TC1650466, TC1758512
DoTS	DT.101713001, DT.493466, DT.94372298
NIA Mouse Gene Index	U024564
Consensus CDS Project	CCDS17785.1
International Mouse Knockout Project Status	Vcam1

Sequences

Length	Strain/Species
genomic	22329	NCBI Gene Model | MGI Sequence Detail	19669	C57BL/6J
transcript	NM_011693	RefSeq | MGI Sequence Detail	3398	Not Specified
polypeptide	P29533	UniProt | EBI | MGI Sequence Detail	739	Not Applicable

All sequences(44) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(193 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008424	Immunoglobulin C2-set
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR003987	Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
InterPro	IPR003989	Vascular cell adhesion molecule-1
Protein Ontology	PR:000001970	vascular cell adhesion protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:18518 Osborn L, et al., Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203-11
(Latest) J:193165 Choi E, et al., Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308
All references(175)

Other accession IDs

MGD-MRK-15384, MGD-MRK-15385