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Vcam1
Gene Detail
Symbol

Name
ID
Vcam1
vascular cell adhesion molecule 1
MGI:98926
Synonyms
CD106, Vcam-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
50.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:116110020-116129688 bp, - strand
From NCBI annotation of GRCm38

  19669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:838  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 2 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: vascular cell adhesion protein 1
Gene Tree: Vcam1

Human
homologs
Human Homolog VCAM1, vascular cell adhesion molecule 1
NCBI Gene ID 7412
neXtProt AC  NX_P19320
Human Synonyms  CD106, INCAM-100
Human Chr (Location)  1p32-p31; chr1:100719640-100739045 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.
 
Interactions
Vcam1 interacts with 178 markers (Mir1b, Mir7-1, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (77 records)
Data Summary: Results (108)    Tissues (59)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 58
RNA in situ 46
RT-PCR 4
cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(13) cDNA(28) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000027962 (Evidence)
Entrez Gene22329 (Evidence)
DFCITC1574873, TC1582765, TC1650466, TC1758512
DoTSDT.101713001, DT.493466, DT.94372298
NIA Mouse Gene IndexU024564
Consensus CDS ProjectCCDS17785.1
International Mouse Knockout Project StatusVcam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22329 NCBI Gene Model | MGI Sequence Detail 19669 C57BL/6J ±  kb
transcript NM_011693 RefSeq | MGI Sequence Detail 3398 Not Specified 
polypeptide P29533 UniProt | EBI | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008424 Immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
InterPro IPR003989 Vascular cell adhesion molecule-1
Protein Ontology PR:000001970 vascular cell adhesion protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:18518 Osborn L, et al., Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203-11
(Latest) J:211622 DeFalco T, et al., Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
All references(185)
Other
accession IDs
MGD-MRK-15384, MGD-MRK-15385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory