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Vcam1 Gene Detail
Summary
  • Symbol
    Vcam1
  • Name
    vascular cell adhesion molecule 1
  • Synonyms
    CD106, Vcam-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98926
    NCBI Gene: 22329
  • Gene Overview
    MyGene.info: VCAM1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:116110020-116129688 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.17 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98926
protein coding gene Chr3:116109949-116129688 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027807
protein coding gene Chr3:117989101-118009678 (-)
A/J MGP_AJ_G0027765
protein coding gene Chr3:114123397-114143037 (-)
AKR/J MGP_AKRJ_G0027731
protein coding gene Chr3:117005748-117025385 (-)
BALB/cJ MGP_BALBcJ_G0027777
protein coding gene Chr3:113971734-113991490 (-)
C3H/HeJ MGP_C3HHeJ_G0027508
protein coding gene Chr3:117372154-117392170 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028223
protein coding gene Chr3:122321392-122342290 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025562
protein coding gene Chr3:109817917-109837522 (-)
CAST/EiJ MGP_CASTEiJ_G0026964
protein coding gene Chr3:116649352-116669127 (-)
CBA/J MGP_CBAJ_G0027483
protein coding gene Chr3:126490003-126510822 (-)
DBA/2J MGP_DBA2J_G0027624
protein coding gene Chr3:113365834-113385282 (-)
FVB/NJ MGP_FVBNJ_G0027592
protein coding gene Chr3:111004924-111024712 (-)
LP/J MGP_LPJ_G0027734
protein coding gene Chr3:119533569-119553141 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027622
protein coding gene Chr3:133863122-133883130 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028279
protein coding gene Chr3:116559983-116580549 (-)
PWK/PhJ MGP_PWKPhJ_G0026690
protein coding gene Chr3:113002086-113022241 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026512
protein coding gene Chr3:114562116-114582853 (-)
WSB/EiJ MGP_WSBEiJ_G0027044
protein coding gene Chr3:117235355-117254823 (-)



Homology
more
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD106, INCAM-100
  • Links
    NCBI Gene ID: 7412
    neXtProt AC: NX_P19320
    UniProt: P19320

  • Chr Location
    1p21.2; chr1:100719640-100739045 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 7 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22329 NCBI Gene Model | MGI Sequence Detail 19669 C57BL/6J ±  kb
    transcript NM_011693 RefSeq | MGI Sequence Detail 3398 Not Specified  
    polypeptide P29533 UniProt | EBI | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 13
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-15384, MGD-MRK-15385
    References
    more
    • Summaries
      All 238
      Developmental Gene Expression 93
      Diseases 1
      Gene Ontology 15
      Phenotypes 28
    • Earliest
      J:18518 Osborn L, et al., Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203-11
    • Latest
      J:257839 Li S, et al., Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior. Cell Res. 2018 Feb;28(2):221-248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory