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Vcam1 Gene Detail
Summary
  • Symbol
    Vcam1
  • Name
    vascular cell adhesion molecule 1
  • Synonyms
    CD106, Vcam-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98926
    NCBI Gene: 22329
  • Gene Overview
    MyGene.info: VCAM1
Location & Maps
more
  • Sequence Map
    Chr3:116109949-116129688 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19740 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.17 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
    Orthology source: HomoloGene
  • Synonyms
    CD106, INCAM-100
  • Links
    NCBI Gene ID: 7412
    neXtProt AC: NX_P19320

  • Chr Location
    1p32-p31; chr1:100719640-100739045 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 7 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Vcam1
  • Incidental Mutations
Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054446 VEGA Gene Model | MGI Sequence Detail 19740 C57BL/6J ±  kb
transcript OTTMUST00000135027 VEGA | MGI Sequence Detail 3469 Not Applicable  
polypeptide OTTMUSP00000071533 VEGA | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    227 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 44
    Genomic 13
    cDNA 28
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-15384, MGD-MRK-15385
References
more
  • Summaries
    All 189
    Developmental Gene Expression 83
    Gene Ontology 13
    Phenotypes 24
  • Earliest
    J:18518 Osborn L, et al., Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203-11
  • Latest
    J:227422 Karpova T, et al., Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Biol Reprod. 2015 Oct;93(4):83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory