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Scgb1a1
Gene Detail
 Symbol
Name
ID
Scgb1a1
secretoglobin, family 1A, member 1 (uteroglobin)
MGI:98919
Synonyms Blastokinin, CC10, CC16, CCSP, clara cell secretory protein, PCB-BP, UG, Utg
Feature Type protein coding gene
Genetic Map
Chromosome 19
6.05 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:9083636-9087958 bp, - strand
From VEGA annotation of GRCm38

  4323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: uteroglobin
Gene Tree: Scgb1a1

Human
homologs
Human Homolog SCGB1A1, secretoglobin, family 1A, member 1 (uteroglobin)
NCBI Gene ID 7356
neXtProt AC  NX_P11684
Human Synonyms  CC10, CC16, CCPBP, CCSP, UGB, UP1, UP-1
Human Chr (Location)  11q12.3; chr11:62419035-62423206 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SCGB1A1
Alleles
and
phenotypes
All alleles(9) : Targeted(9)
 
Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process negative regulation of interferon-gamma production, negative regulation of interleukin-13 production, ...
Component cytoplasm, endoplasmic reticulum, ...
Function phospholipase A2 inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (158 records)
Data Summary: Results (79)    Tissues (34)    Images (31)
Theiler Stages: 15, 16, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 44
RNA in situ 11
Northern blot 12
RT-PCR 6
Nuclease S1 6
cDNA source data(267)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(282) Genomic(4) cDNA(270) Primer pair(2) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035954 (Evidence)
Ensembl Gene ModelENSMUSG00000024653 (Evidence)
Entrez Gene22287 (Evidence)
UniGene2258
DFCITC1573560, TC1582609
DoTSDT.101406030, DT.101406031, DT.94295541
Consensus CDS ProjectCCDS37911.1
International Mouse Knockout Project StatusScgb1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035954 VEGA Gene Model | MGI Sequence Detail 4323 C57BL/6J ±  kb
transcript OTTMUST00000092237 VEGA | MGI Sequence Detail 476 Not Applicable 
polypeptide OTTMUSP00000050926 VEGA | MGI Sequence Detail 96 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016126 Secretoglobin
InterPro IPR000329 Uteroglobin-like
Protein Ontology PR:000014505 uteroglobin
References (Earliest) J:640 Sandmoller A, et al., Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice. Mech Dev. 1991 Mar;34(1):57-67
(Latest) J:203056 Hines EA, et al., Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19444-9
All references(226)
Other
accession IDs
MGD-MRK-15376

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory