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Scgb1a1
Gene Detail
Symbol

Name
ID
Scgb1a1
secretoglobin, family 1A, member 1 (uteroglobin)
MGI:98919
Synonyms
Blastokinin, CC10, CC16, CCSP, clara cell secretory protein, PCB-BP, UG, Utg
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.05 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:9083636-9087958 bp, - strand
From VEGA annotation of GRCm38

  4323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: SCGB1A1
Protein SuperFamily: uteroglobin
Gene Tree: Scgb1a1

Human
homologs
SCGB1A1, secretoglobin, family 1A, member 1 (uteroglobin)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7356
neXtProt AC: NX_P11684

Human Synonyms: CC10, CC16, CCPBP, CCSP, UGB, UP1, UP-1

Human Chr (Location): 11q12.3; chr11:62419035-62423206 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.
 
Interactions
Scgb1a1 interacts with 23 markers (Mir25, Mir32, Mir34a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (174 records)
Data Summary: Results (84)    Tissues (38)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 48
RNA in situ 11
Northern blot 12
RT-PCR 7
Nuclease S1 6
cDNA source data(267)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(283) Genomic(4) cDNA(270) Primer pair(3) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035954 (Evidence)
Ensembl Gene Model ENSMUSG00000024653 (Evidence)
Entrez Gene 22287 (Evidence)
UniGene 2258
DFCI TC1573560, TC1582609
DoTS DT.101406030, DT.101406031, DT.94295541
Consensus CDS Project CCDS37911.1
International Mouse Phenotyping Consortium Status Scgb1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035954 VEGA Gene Model | MGI Sequence Detail 4323 C57BL/6J ±  kb
transcript OTTMUST00000092237 VEGA | MGI Sequence Detail 476 Not Applicable 
polypeptide OTTMUSP00000050926 VEGA | MGI Sequence Detail 96 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016126 Secretoglobin
InterPro IPR000329 Uteroglobin-like
Protein Ontology PR:000014505 uteroglobin
References
(Earliest) J:640 Sandmoller A, et al., Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice. Mech Dev. 1991 Mar;34(1):57-67
(Latest) J:220467 Galvis LA, et al., Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development. 2015 Apr 15;142(8):1458-69
All references(249)
Other
accession IDs
MGD-MRK-15376

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory