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Scgb1a1 Gene Detail
Summary
  • Symbol
    Scgb1a1
  • Name
    secretoglobin, family 1A, member 1 (uteroglobin)
  • Synonyms
    Blastokinin, CC10, CC16, CCSP, clara cell secretory protein, PCB-BP, UG, Utg
  • Feature Type
    protein coding gene
  • IDs
    MGI:98919
    NCBI Gene: 22287
  • Gene Overview
    MyGene.info: SCGB1A1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 19, 6.05 cM, cytoband A
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CC10, CC16, CCPBP, CCSP, UGB, UP1, UP-1
  • Links
    NCBI Gene ID: 7356
    neXtProt AC: NX_P11684
    UniProt: P11684

  • Chr Location
    11q12.3; chr11:62419035-62423206 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035954 VEGA Gene Model | MGI Sequence Detail 4323 C57BL/6J ±  kb
    transcript OTTMUST00000092237 VEGA | MGI Sequence Detail 476 Not Applicable  
    polypeptide OTTMUSP00000050926 VEGA | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      25 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 286
      Genomic 4
      cDNA 270
      Primer pair 5
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15376
    References
    more
    • Summaries
      All 306
      Developmental Gene Expression 212
      Gene Ontology 7
      Phenotypes 65
    • Earliest
      J:640 Sandmoller A, et al., Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice. Mech Dev. 1991 Mar;34(1):57-67
    • Latest
      J:260367 Yee M, et al., Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells. Am J Respir Cell Mol Biol. 2017 Apr;56(4):453-464

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory