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Scgb1a1 Gene Detail
Summary
  • Symbol
    Scgb1a1
  • Name
    secretoglobin, family 1A, member 1 (uteroglobin)
  • Synonyms
    Blastokinin, CC10, CC16, CCSP, clara cell secretory protein, PCB-BP, UG, Utg
  • Feature Type
    protein coding gene
  • IDs
    MGI:98919
    NCBI Gene: 22287
  • Gene Overview
    MyGene.info: SCGB1A1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:9083642-9087956 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.05 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98919
protein coding gene Chr19:9083636-9087958 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024829
protein coding gene Chr19:6379744-6384066 (-)
A/J MGP_AJ_G0024797
protein coding gene Chr19:6037431-6041755 (-)
AKR/J MGP_AKRJ_G0024772
protein coding gene Chr19:6144685-6149007 (-)
BALB/cJ MGP_BALBcJ_G0024797
protein coding gene Chr19:6147164-6151966 (-)
C3H/HeJ MGP_C3HHeJ_G0024563
protein coding gene Chr19:6238227-6242539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025244
protein coding gene Chr19:6532181-6536489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022673
protein coding gene Chr19:6291904-6296219 (-)
CAST/EiJ MGP_CASTEiJ_G0024036
protein coding gene Chr19:5892496-5898730 (-)
CBA/J MGP_CBAJ_G0024537
protein coding gene Chr19:6635667-6640059 (-)
DBA/2J MGP_DBA2J_G0024664
protein coding gene Chr19:5878569-5883124 (-)
FVB/NJ MGP_FVBNJ_G0024631
protein coding gene Chr19:5936401-5940697 (-)
LP/J MGP_LPJ_G0024751
protein coding gene Chr19:6283035-6287347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024658
protein coding gene Chr19:6488410-6492658 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025293
protein coding gene Chr19:6186748-6191433 (-)
PWK/PhJ MGP_PWKPhJ_G0023781
protein coding gene Chr19:5557015-5561743 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023586
protein coding gene Chr19:5796103-5800270 (-)
WSB/EiJ MGP_WSBEiJ_G0024098
protein coding gene Chr19:6158912-6163229 (-)



Homology
more
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CC10, CC16, CCPBP, CCSP, UGB, UP1, UP-1
  • Links
    NCBI Gene ID: 7356
    neXtProt AC: NX_P11684
    UniProt: P11684

  • Chr Location
    11q12.3; chr11:62419035-62423206 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22287 NCBI Gene Model | MGI Sequence Detail 4315 C57BL/6J ±  kb
    transcript NM_011681 RefSeq | MGI Sequence Detail 468 C57BL/6  
    polypeptide Q06318 UniProt | EBI | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 287
      Genomic 4
      cDNA 271
      Primer pair 5
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15376
    References
    more
    • Summaries
      All 320
      Developmental Gene Expression 219
      Gene Ontology 9
      Phenotypes 70
    • Earliest
      J:640 Sandmoller A, et al., Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice. Mech Dev. 1991 Mar;34(1):57-67
    • Latest
      J:266598 Ustiyan V, et al., FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol. 2018 Nov 1;443(1):50-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory