Scgb1a1
Gene Detail

Symbol Name ID

Scgb1a1 secretoglobin, family 1A, member 1 (uteroglobin) MGI:98919

Synonyms

Blastokinin, CC10, CC16, CCSP, clara cell secretory protein, PCB-BP, UG, Utg

Feature Type

protein coding gene

Genetic Map

Chromosome 19

6.05 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:9083636-9087958 bp, - strand From VEGA annotation of GRCm38   4323 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: uteroglobin
Gene Tree: Scgb1a1

Human homologs

Human Homolog		SCGB1A1, secretoglobin, family 1A, member 1 (uteroglobin)
NCBI Gene ID		7356
neXtProt AC		NX_P11684
Human Synonyms		CC10, CC16, CCPBP, CCSP, UGB, UP1, UP-1
Human Chr (Location)		11q12.3; chr11:62186507-62190678 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SCGB1A1

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	negative regulation of catalytic activity, negative regulation of interferon-gamma production, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	phospholipase A2 inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (139 records)
Data Summary: Results (72)    Tissues (32)    Images (28)
Theiler Stages: 16, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	42
RNA in situ	10
Northern blot	12
RT-PCR	2
Nuclease S1	6

cDNA source data(267)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(280) Genomic(4) cDNA(270) Primer pair(1) Other(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035954 (Evidence)
Ensembl Gene Model	ENSMUSG00000024653 (Evidence)
Entrez Gene	22287 (Evidence)
UniGene	2258
DFCI	TC1573560, TC1582609
DoTS	DT.101406030, DT.101406031, DT.94295541
Consensus CDS Project	CCDS37911.1
International Mouse Knockout Project Status	Scgb1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035954	VEGA Gene Model | MGI Sequence Detail	4323	C57BL/6J
transcript	OTTMUST00000092237	VEGA | MGI Sequence Detail	476	Not Applicable
polypeptide	OTTMUSP00000050926	VEGA | MGI Sequence Detail	96	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016126	Secretoglobin
InterPro	IPR000329	Uteroglobin-like
InterPro	IPR006039	Uteroglobin-like family
InterPro	IPR006038	Uteroglobin-like superfamily
Protein Ontology	PR:000014505	uteroglobin

References

(Earliest) J:640 Sandmoller A, et al., Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice. Mech Dev. 1991 Mar;34(1):57-67
(Latest) J:195044 Wang Y, et al., Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
All references(207)

Other accession IDs

MGD-MRK-15376